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Games Like Operation Pill

60+ similar titles based on shared tags and player behavior. Themes include Medical Sim, Simulation, VR, Singleplayer.

Operation Pill header art

Operation Pill is the story of a small and brave pill that gets into your body and saves it from pathogenic bacteria. Arm yourself with an electrostatic shield and a germicidal cannon and save your body!

Reviews: Positive — 91% — of 11 reviews
Released: 2022-05-02
Developer: xr407
Genres: Casual, Free To Play, Indie, Simulation, Early Access
Platforms: Windows

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  1. #1 Surgeon Simulator VR: Meet The Medic
    97% matchMostly Positive77% of 591 reviews2016
    Dev: Bossa Studios
    Windows
    Median: 18 minMean: 1.6 hrs≥1hr: 14%

    Surgeon Simulator VR: Meet the Medic – be the Medic and operate on the Heavy in this free and exclusive teaser for the HTC Vive!

    Why similar: Medical Sim 73.7%, VR 22%, Simulation 3.3%, Indie 0.9%

  2. #2 Surgeon Simulator: Experience Reality
    96% matchMixed58% of 1,259 reviews2016
    Dev: Bossa Studios
    Windows
    Median: 54 minMean: 2.2 hrs≥1hr: 48%

    Surgeon Simulator is bringing the ER to VR! The most critically acclaimed and infamous surgery simulation game as you have never seen it before! Featuring all of the surgeries and twisted humour of the original favourite plus a few new surprises...

    Why similar: Medical Sim 61.6%, VR 32.8%, Simulation 4.2%, Indie 1.4%

  3. #3 Human Constructor VR
    96% match3 user reviews67% of 3 reviews2020
    Dev: Exxit
    Windows

    Human Constructor VR is a virtual reality application designed for detailed study of the human structure and individual organs, bones, and muscles. This application contains only the anatomy of the male human body.

    Why similar: Medical Sim 66.4%, VR 28.8%, Simulation 3.6%, Singleplayer 1.3%

  4. #4 RoboDoc Jr
    95% matchNo user reviews2025
    Dev: Marion SurgicalPub: Marion Surgical Inc
    Windows

    A fun space adventure game where kids become alien medics! Use cool futuristic tools to help friendly aliens across 12 exciting missions. Solve puzzles, fix alien tech, and save the day with steady hands and smart thinking!

    Why similar: Medical Sim 67%, VR 23%, Casual 7%, Simulation 2%, Singleplayer 0.9%

  5. #5 Medic Simulator: Combat Zone
    94% match1 user reviews100% of 1 reviews2026
    Dev: Code Lab
    Windows

    Rescue wounded soldiers under enemy fire, control severe bleeding, apply tourniquets, perform emergency procedures, and transport patients to safety. Use real combat triage principles, react to unpredictable threats, and engage enemies when necessary. Only the fastest and bravest save lives.

    Why similar: Medical Sim 61.3%, VR 30.3%, Simulation 3.7%, Arcade 2.5%, Indie 1.6%

  6. #6 Doctor Galaxy
    94% matchNo user reviews
    Dev: Ignite Game Studio

    Enter the absurd world of Doctor Galaxy, a hilarious VR sandbox where mad science meets intergalactic chaos. Create bizarre alien specimens by swapping parts, printing limbs, and painting them with wild colors. Then, launch your twisted creations to distant planets. Every experiment is unpredictable

    Why similar: Medical Sim 44.5%, VR 31.2%, Casual 9.7%, Arcade 6.5%, 3D 5.1%

  7. #7 Medical verdict
    93% matchMixed57% of 53 reviews2018
    Dev: Volokitin Andrey
    Windows

    Here is a fun simulator of passing a medical examination in the Chelyabinsk clinic with realistic graphics and interesting gameplay! Take the coronavirus test! Collect as many virtual health points as you can, but remember ... this is just a game!

    Why similar: Medical Sim 82.9%, Casual 8.6%, Simulation 6%, Indie 2.5%

  8. #8 Ice Rescue Simulator VR
    92% matchNo user reviews
    Dev: Sempiternal Rain
    Windows

    Ice Rescue Simulator VR – a fun ice emergency rescue simulator where a victim’s life is in your hands, and any wrong move can lead to failure!

    Why similar: Medical Sim 71.8%, VR 16.3%, Arcade 4.6%, Simulation 3.7%, 3D 3.1%

  9. #9 VR TKA Surgery Simulator
    91% match2 user reviews0% of 2 reviews2024
    Dev: Kliniker
    Windows

    Get ready to learn all the subtleties of the surgery by practicing it in the applied VR TKA training by Prof. Dr. Ertugrul Aksahin, one of the world's leading orthopedic surgeons!

    Why similar: Medical Sim 63.3%, VR 28.1%, Simulation 7.5%, Singleplayer 1.1%

  10. #10 Dentist Simulator 2
    91% match4 user reviews100% of 4 reviews2025
    Dev: Code Lab
    Windows

    Screams, panic, and fear of the dentist’s chair — now YOU hold the drill! Master anesthesia, gum surgery, extractions, and bleeding control with precision. Go beyond basics: apply braces, craft gold & silver teeth, implants, and use inhalation sedation. Keep patients calm or hear their screams!

    Why similar: Medical Sim 59.2%, VR 29.2%, Casual 4.4%, Simulation 3.3%, PvE 2.2%

  11. #11 Dr. Cares - Amy's Pet Clinic
    90% matchMostly Positive79% of 77 reviews2018
    Dev: NitrealPub: GameHouse
    Windows · Mac

    Get ready to test your vet skills in Dr. Cares - Amy's Pet Clinic!

    Why similar: Medical Sim 82.4%, Casual 10.5%, Simulation 7.1%

  12. #12 Heart's Medicine - Hospital Heat
    89% matchVery Positive96% of 366 reviews2017
    Dev: Blue GiraffePub: GameHouse
    Windows · Mac
    Median: 5.1 hrsMean: 8.7 hrs≥1hr: 93%

    The long awaited sequel to "Heart's Medicine - Time to Heal". An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring doctor at Little Creek Hospital!

    Why similar: Medical Sim 82.6%, Casual 9%, Simulation 6%, Indie 2.4%

  13. #13 Pentamania: Alchemy Madness
    88% match4 user reviews50% of 4 reviews2025
    Dev: Athmyx
    Windows

    Step into a VR alchemy workshop, gather rare ingredients, and combine them with cauldrons, and magical machines to brew fantastical potions. Experiment, discover, and deliver your creations in an immersive fantasy experience!!

    Why similar: Medical Sim 58.4%, VR 19.9%, Casual 10.8%, Simulation 6.7%, Linear 2.6%

  14. #14 Valley General Hospital: NiVR
    86% match2 user reviews50% of 2 reviews2021
    Dev: Valley General
    Windows

    An exciting new approach to training and simulation in Healthcare.

    Why similar: Medical Sim 68.5%, VR 21.1%, Simulation 6.5%, 3D 3.2%, Singleplayer 0.7%

  15. #15 Heart's Medicine - Time to Heal
    84% matchVery Positive94% of 884 reviews2016
    Dev: Blue GiraffePub: GameHouse
    Windows · Mac
    Median: 6.0 hrsMean: 12.2 hrs≥1hr: 92%

    An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring surgeon at Little Creek Hospital!

    Why similar: Medical Sim 83.5%, Casual 9.4%, Simulation 4.1%, Indie 2.1%, Singleplayer 1%

  16. #16 Code Blue Idle
    84% matchNo user reviews
    Dev: Sulcus Games
    Windows · Mac · Linux

    A medical idle game with real hospital depth. Treat patients, hire staff, and unlock departments from the ED to the ICU — then watch your hospital run itself while you sleep.

    Why similar: Medical Sim 57.6%, Idler 32%, Casual 4.6%, Simulation 4.2%, Singleplayer 0.9%

  17. #17 Fun Hospital
    83% matchMixed64% of 609 reviews2018
    Dev: OrangesGame Technology Limited
    Windows · Mac
    Median: 1.2 hrsMean: 32.4 hrs≥1hr: 53%

    Build your own theme hospital! Here, you might meet patients with a lot of hair, or no hair; strange aliens, evil guy, super hero…

    Why similar: Medical Sim 78.3%, Casual 11.4%, Simulation 7.5%, Indie 2.9%

  18. #18 Reanimation Inc.
    81% matchVery Positive84% of 131 reviews2019
    Dev: Dmitrii Lomakin
    Windows

    Reanimation inc is a completely realistic simulation - real urgent conditions and diseases, real protocols of care used in an ambulance, realistic simulation of the body! Do you like realistic games about medicine and simulators, games you need to think about? You 'll be happy!

    Why similar: Medical Sim 90.5%, Simulation 6.8%, Indie 2.7%

  19. #19 Medic Simulator
    82% matchNo user reviews
    Dev: Eathrabaria
    Windows

    Become a doctor and treat patients in every area of medicine. Become a cardiologist, psychiatrist, dentist, dermatologist, oncologist, surgeon, ophthalmologist, neurologist…!

    Why similar: Medical Sim 66.4%, Science 19.9%, Simulation 7.7%, 3D 5%, Singleplayer 1%

  20. #20 Real Pharmacy Simulator
    80% matchMostly Negative27% of 11 reviews2024
    Dev: Mannered Monster
    Windows

    Become the owner of a pharmacy in Real Pharmacy Simulator! Manage the business, serve customers, and balance profit with ethics. Order medicines, organize the space, and decide how to run your business - honestly or riskily. Your decisions will determine the fate of the pharmacy!

    Why similar: Medical Sim 57.7%, Idler 23.8%, Casual 6.6%, 3D 4.5%, Simulation 4.3%

  21. #21 PT+
    81% match8 user reviews88% of 8 reviews2020
    Dev: Liam McMainsPub: Axis Technologies LLC
    Windows

    Use virtual reality to learn how to stretch and exercise your neck

    Why similar: Medical Sim 51.8%, VR 24.4%, Science 15.5%, PvE 3.6%, Simulation 3.4%

  22. #22 Kellogg's Gut Bacteria Reef
    79% matchVery Positive82% of 50 reviews2021
    Dev: NAKATOMIPub: KELLOGG
    Windows

    Explore the human gut like never before!

    Why similar: Medical Sim 66.4%, VR 27.6%, 3D 5%, Singleplayer 1.1%

  23. #23 WirtschaftsWoche Virtual Reality
    79% match3 user reviews67% of 3 reviews2021
    Dev: Michael BertramPub: Handelsblatt GmbH – ein Unternehmen der Handelsblatt Media Group GmbH & Co. KG
    Windows

    Virtual Reality Simulation Experience in Virtual Reality how an electric car is created, or save a person's life in the hospital of the future.

    Why similar: Medical Sim 47.4%, VR 30.3%, Science 18.2%, Simulation 3.1%, Singleplayer 0.9%

  24. #24 Element Idle
    76% matchMixed64% of 25 reviews2026
    Dev: Chalk Creative
    Windows

    Click the atom, earn particles, evolve through all 118 elements of the periodic table. A free idle/clicker game with a deep skill tree, prestige system, and Steam achievements.

    Why similar: Idler 48.9%, Science 31.4%, Casual 15.4%, Singleplayer 2.6%, Indie 1.6%

  25. #25 Dr Greenstuff
    78% matchVery Positive87% of 149 reviews2018
    Dev: Black DiskettePub: Black Diskette Studio
    Windows

    Discover the life of Dr Greenstuff, grow marijuana, coca, make meth', drugs and more to keep your legal/illegal business running.

    Why similar: Medical Sim 89.4%, Simulation 7.5%, Indie 3.1%

  26. #26 Vaccine Delivery Adventure
    78% matchMostly Positive73% of 15 reviews2022
    Dev: The VALIDATE Network
    Windows

    Vaccine Delivery Adventure is a classic side-scrolling action game where a healthcare worker has to overcome the challenges of delivering the BCG Vaccine to the communities that need it!

    Why similar: Medical Sim 73.7%, Science 14%, Casual 7.4%, 3D 4.1%, Singleplayer 0.9%

  27. #27 Sopwith VR
    77% matchVery Positive86% of 340 reviews2018
    Dev: David Mohr Gould
    Windows

    Shoot down triplanes and attack tanks with your Sopwith biplane. Simple World War One flight combat simulator with touch controls, airfoil physics, computer-controlled opponents, and destructible environments, inspired by David L. Clark's classic DOS game from 1984.

    Why similar: VR 64%, Flight 16.5%, Casual 11.2%, Simulation 8.3%

  28. #28 Dr. Chatelet: Faith 神医
    74% matchVery Positive85% of 132 reviews2022
    Dev: MuccyGames
    Windows · Mac

    Amputations, bloodletting, alchemy - all of which seem unthinkable today - were the treatment options that medieval doctors revered. You must face challenges one after another and experience gains and losses in the course of your constant adventures

    Why similar: Medical Sim 61.2%, Science 14.7%, Idler 13%, Casual 6.7%, Simulation 4.4%

  29. #29 My Universe - Doctors & Nurses
    75% matchMostly Negative38% of 16 reviews2022
    Dev: It Matters GamesPub: Microids
    Windows · Mac

    Take turns to play either a doctor or nurse. Diagnose illnesses and infections so as to treat and help your many patients. Set out on an adventure in a buzzing hospital environment. Meet all sorts of different characters and discover a story full of surprises.

    Why similar: Medical Sim 79.2%, Casual 9.4%, 3D 5%, Simulation 4.9%, Singleplayer 1.5%

  30. #30 Bacterium / 生命之旅
    75% matchPositive84% of 49 reviews2018
    Dev: Dragon Whisper GamePub: Zodiac Interactive
    Windows

    In the coming decades, a huge breakthrough in nano-medical technology will bring a new light to cure terminally ill patients. As a nano-robot operator, you will be involved in a battle between nanobots and diseases!

    Why similar: Medical Sim 89.9%, Simulation 7.1%, Indie 3%

  31. #31 Herbalist Simulator
    76% matchMostly Negative21% of 14 reviews2020
    Dev: EJRGames
    Windows

    Become a herbalist in a small village. Treat various diseases using natural methods. Prepare healing mixtures. Travel to search for better ingredients. Do not wait. Find your vocation to heal people…

    Why similar: Medical Sim 41.8%, VR 16.1%, Casual 14.5%, Simulation 10.3%, Science 9.9%

  32. #32 Scalpel, Please!
    74% matchNo user reviews
    Dev: WoolCat Games
    Windows

    Scalpel, Please! is a ridiculous medical simulator where you assist a blindfolded surgeon. Provide tools, talk to him, and give your full support. But be careful: he’ll remember everything you do and react accordingly. Will you manage to keep your job?

    Why similar: Medical Sim 73.8%, Casual 11.7%, Simulation 7.3%, 3D 5.7%, Indie 1%

  33. #33 Lucky Night: Texas Hold'em VR
    73% matchMostly Positive80% of 180 reviews2017
    Dev: ATC Games
    Windows
    Median: 1.1 hrsMean: 10.2 hrs≥1hr: 52%

    Have an enjoyable Texas hold’em game in virtual room with real players by HTC Vive or Oculus Rift.

    Why similar: VR 81.9%, Casual 18.1%

  34. #34 小邦迪的奇妙冒险
    72% matchPositive89% of 18 reviews2021
    Dev: Puyuan YePub: Band-Aid
    Windows · Mac

    在《小邦迪的奇妙冒险》中与小邦迪一同学习急救知识,拯救吴家于各种急症之中。

    Why similar: Medical Sim 80.3%, Casual 7.7%, Linear 4.8%, Simulation 4.7%, Singleplayer 1.2%

  35. #35 Highway Madness
    73% matchMostly Positive70% of 50 reviews2018
    Dev: Game Cooks
    Windows
    Median: 1.5 hrsMean: 11.5 hrs≥1hr: 51%

    Highway Madness is a social VR game where you get to play with old and new friends from all over the world! Pick your character then choose from a selection of fun games including Standoff, Road Crossing, Roof jumping and Shootout! So what are you waiting for? Come on in and join the Madness!

    Why similar: VR 80.5%, Casual 19.5%

  36. #36 MediSim: Emergency Response
    73% matchNo user reviews
    Dev: Mehmet Hilmi Değirmenci
    Windows

    As a young doctor, save lives in emergencies, advance from a health center to a major hospital, and manage your own facility. Perform first aid, and diagnostics, take on ambulance and helicopter missions, and build your medical team. A realistic medical simulation where every decision matters!

    Why similar: Medical Sim 77.4%, Casual 10%, Simulation 7.9%, 3D 4%, Singleplayer 0.8%

  37. #37 Flappy Person
    72% matchNo user reviews
    Dev: POLYGONWARE
    Windows

    Ever wondered how it is to be like a flappy person? Well now you can become one.

    Why similar: VR 57.6%, Flight 15.1%, Casual 13.9%, Arcade 9.1%, Singleplayer 2.8%

  38. #38 中医模拟传承人
    69% matchPositive87% of 15 reviews2024
    Dev: guizhi0011
    Windows

    A game where everyone can learn traditional Chinese medicine.

    Why similar: Medical Sim 80.2%, Simulation 8.1%, Casual 8.1%, Indie 2.4%, Singleplayer 1.2%

  39. #39 Endless Labyrinth
    71% matchMostly Positive75% of 20 reviews2016
    Dev: Mike Prosser
    Windows

    Endless Labyrinth is a simple, relaxing game of exploration and collection. A maze is randomly generated, forever in every direction. Hidden in the maze are lots of gems to collect! There are also special things to find while exploring, like statues or other interesting rooms.

    Why similar: VR 78.6%, Casual 21.4%

  40. #40 The Cable Center - Virtual Archive
    70% matchPositive81% of 21 reviews2017
    Dev: The Cable Center
    Windows

    The Cable Center is proud to announce our Virtual Reality Archives Exhibit. The Center started experimenting with virtual reality in late 2013 with the goal of capturing objects to share in exhibits and videos. Four years later, we have elevated our work to a whole new level.

    Why similar: VR 77.1%, Casual 22.9%

  41. #41 Ganbatte
    71% match3 user reviews67% of 3 reviews2018
    Dev: Mimicry
    Windows

    Ganbatte is a competitive social multiplayer arcade game for VR, about cats, in space, eating sushi. Try to eat as much valuable sushi as you can and reach the highest score.

    Why similar: VR 62.5%, Casual 19.1%, Arcade 12.7%, Indie 5.8%

  42. #42 Isle of the Dead
    70% matchMostly Positive79% of 48 reviews2019
    Dev: Les Produits FraisPub: Astrea
    Windows

    Step into Böcklin’s masterpiece, in an award-winning VR experience. ISLE OF THE DEAD is a timeless, fascinating journey towards our final destination, guided by Charon, ferryman of the Underworld.

    Why similar: VR 81%, Casual 14.6%, Indie 4.4%

  43. #43 Old Friend
    69% matchVery Positive94% of 142 reviews2016
    Dev: Tyler HurdPub: Wevr, Inc
    Windows

    Lose yourself in a vibrant and interactive psychedelic dance party brimming with joyful insanity.

    Why similar: VR 76.2%, Casual 23.8%

  44. #44 Rexodus: A VR Story Experience
    70% matchMostly Positive72% of 121 reviews2016
    Dev: Steelehouse VR Studios
    Windows

    Rexodus: A VR Story Experience is based on the Dark Horse Graphic Novel Rexodus. This is a VR narrative experience set in a universe where dinosaurs didn't go extinct, they left Earth. Those dinosaurs, utilizing their own advanced technology, are traversing the galaxy.

    Why similar: VR 85.1%, Casual 11.4%, Indie 3.4%

  45. #45 Hospital Manager
    71% matchMixed46% of 255 reviews2015
    Dev: CCCPPub: Microids Indie
    Windows · Mac
    Median: 1.1 hrsMean: 9.5 hrs≥1hr: 56%

    Experience something novel, bursting with extraordinary phenomena and strange situations in your hospital! Only you have the power to make the best decisions and to make your hospital the most popular one! But beware: Several events will add some spice to your life! Embark on the career of your life!

    Why similar: Medical Sim 94.2%, Simulation 5.8%

  46. #46 Night Shift Hospital
    69% matchNo user reviews
    Dev: Knitted CatsPub: Polden Publishing
    Windows

    A chaotic co-op job sim for up to 4 players about night-shift doctors. Handle a bizarre stream of patients, diagnose illnesses, and assign people to the correct treatment zones. Work as a team, get through nightly crises, and try your best not to get fired!

    Why similar: Medical Sim 73.8%, Casual 11.5%, Simulation 7.3%, 3D 5.8%, Indie 1%

  47. #47 The Visitor
    68% matchMostly Positive76% of 210 reviews2016
    Dev: Stephen Long
    Windows
    Median: 12 minMean: 4.2 hrs≥1hr: 28%

    The Visitor is a VR horror experience about an unexpected visitor calling to your door in the middle of the night. The game relies heavily on atmosphere, utilizing a dark environment to make the player both as nervous and uncomfortable as possible.

    Why similar: VR 77.9%, Casual 17.1%, Indie 4.9%

  48. #48 疑義照会ウォーズ
    68% matchMostly Negative30% of 20 reviews2021
    Dev: 薬学ゲーム開発プロジェクト
    Windows

    This is a full-fledged adventure game (selectable type) based on the theme of the pharmacist's job, "checking prescription. Determine if the prescription is correct, and if it is, make a "Questionable Inquiry" to the doctor!

    Why similar: Medical Sim 91.4%, Simulation 6.2%, Singleplayer 1.2%, Indie 1.2%

  49. #49 Kygo 'Carry Me' VR Experience
    67% matchPositive87% of 30 reviews2017
    Dev: MPC VRPub: Sony Music Entertainment
    Windows

    Join superstar electronic musician Kygo in this incredible virtual reality experience inspired by the hit song “Carry Me.”

    Why similar: VR 74.2%, Casual 25.8%

  50. #50 Hot Seat Triage
    67% matchNo user reviews
    Dev: System Two Games
    Windows

    Triage is easy until your own brain starts lying to you. Pick patients from a crowded ER, question them under time pressure, and call NOW, SOON or WAIT before their aura fades. Every case hides a cognitive bias built to fool you. Made by an emergency physician.

    Why similar: Medical Sim 80.3%, Simulation 6.2%, Science 5.9%, Arcade 5.6%, Singleplayer 1.2%

  51. #51 Vintage VR
    67% matchVery Positive88% of 104 reviews2016
    Dev: DunderwarePub: MuseumSyndicate.com
    Windows
    Median: 36 minMean: 8.7 hrs≥1hr: 43%

    In the 19th century, when people had no HTC Vives to play with, they resorted to using primitive stereoscopes to see stereoscopic images in 3D! This free VR experience allows you to view a collection of over 700 such images from that era and enjoy them as people saw them over a century ago.

    Why similar: VR 73.3%, Casual 26.7%

  52. #52 GastroRun
    65% matchMostly Positive79% of 14 reviews2024
    Dev: Nuatgames
    Windows

    Gastro Run is a fast-paced educational adventure game full of obstacles, boss fights, races, withlessons placed throughout the game. You play as Gastro, a witty nano-bot whose goal is to help patients with enzyme deficiency break down food as it travels through the digestive system.

    Why similar: Medical Sim 67.1%, Flight 20.1%, Casual 7.5%, 3D 4.9%, Singleplayer 0.4%

  53. #53 The VR Museum of Fine Art
    66% matchVery Positive87% of 320 reviews2016
    Dev: Finn Sinclair
    Windows
    Median: 24 minMean: 6.5 hrs≥1hr: 36%

    JUST UPDATED: Explore the Second Floor of the Museum! Explore a virtual museum in room-scale VR: see famous sculptures in full, 1:1 scale and see famous paintings without the limitations of glass and security guards.

    Why similar: VR 70.3%, Casual 15.2%, Simulation 10.3%, Indie 4.2%

  54. #54 Surgineer
    67% matchNo user reviews
    Dev: Holonautic
    Linux

    Have you ever dreamed of being a real surgeon? Well… you will not learn that here. Discover a crazy universe where you get the opportunity to be the greatest or most terrible doctor.

    Why similar: Medical Sim 82%, Casual 7.2%, Simulation 6%, 3D 2.7%, Singleplayer 1.1%

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Operation Pill cover art

Games Like Operation Pill

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