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Games Like Operation Pill

60+ similar titles based on shared tags and player behavior. Themes include Medical Sim, Simulation, VR, Indie.

Operation Pill header art

Operation Pill is the story of a small and brave pill that gets into your body and saves it from pathogenic bacteria. Arm yourself with an electrostatic shield and a germicidal cannon and save your body!

Reviews: Positive — 91% — of 11 reviews
Released: 2022-05-02
Developer: xr407
Genres: Casual, Free To Play, Indie, Simulation, Early Access
Platforms: Windows

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  1. #1 Surgeon Simulator VR: Meet The Medic
    97% matchMostly Positive77% of 580 reviews2016
    Dev: Bossa Studios
    Windows
    Median: 18 minMean: 1.7 hrs≥1hr: 14%

    Surgeon Simulator VR: Meet the Medic – be the Medic and operate on the Heavy in this free and exclusive teaser for the HTC Vive!

    Why similar: Medical Sim 74.8%, VR 20.8%, Simulation 3.4%, Indie 1%

  2. #2 Surgeon Simulator: Experience Reality
    96% matchMixed57% of 1,197 reviews2016
    Dev: Bossa Studios
    Windows
    Median: 54 minMean: 2.2 hrs≥1hr: 47%

    Surgeon Simulator is bringing the ER to VR! The most critically acclaimed and infamous surgery simulation game as you have never seen it before! Featuring all of the surgeries and twisted humour of the original favourite plus a few new surprises...

    Why similar: Medical Sim 62.5%, VR 31.6%, Simulation 4.4%, Indie 1.5%

  3. #3 Human Constructor VR
    96% match3 user reviews67% of 3 reviews2020
    Dev: Exxit
    Windows

    Human Constructor VR is a virtual reality application designed for detailed study of the human structure and individual organs, bones, and muscles. This application contains only the anatomy of the male human body.

    Why similar: Medical Sim 67.3%, VR 27.7%, Simulation 3.7%, Singleplayer 1.3%

  4. #4 RoboDoc Jr
    95% matchNo user reviews2025
    Dev: Marion SurgicalPub: Sketchy Neurons
    Windows

    A fun space adventure game where kids become alien medics! Use cool futuristic tools to help friendly aliens across 12 exciting missions. Solve puzzles, fix alien tech, and save the day with steady hands and smart thinking!

    Why similar: Medical Sim 67.8%, VR 22.1%, Casual 7.1%, Simulation 2.1%, Singleplayer 0.9%

  5. #5 Medical verdict
    94% matchMixed57% of 53 reviews2018
    Dev: Volokitin Andrey
    Windows

    Here is a fun simulator of passing a medical examination in the Chelyabinsk clinic with realistic graphics and interesting gameplay! Take the coronavirus test! Collect as many virtual health points as you can, but remember ... this is just a game!

    Why similar: Medical Sim 82.8%, Casual 8.6%, Simulation 6.1%, Indie 2.5%

  6. #6 Ice Rescue Simulator VR
    94% matchNo user reviews
    Dev: Sempiternal Rain
    Windows

    Ice Rescue Simulator VR – a fun ice emergency rescue simulator where a victim’s life is in your hands, and any wrong move can lead to failure!

    Why similar: Medical Sim 72.3%, VR 15.5%, Arcade 4.6%, Simulation 3.8%, 3D 3.1%

  7. #7 VR TKA Surgery Simulator
    93% match2 user reviews0% of 2 reviews2024
    Dev: Kliniker
    Windows

    Get ready to learn all the subtleties of the surgery by practicing it in the applied VR TKA training by Prof. Dr. Ertugrul Aksahin, one of the world's leading orthopedic surgeons!

    Why similar: Medical Sim 64.1%, VR 27%, Simulation 7.7%, Singleplayer 1.2%

  8. #8 Dr. Cares - Amy's Pet Clinic
    92% matchMostly Positive79% of 75 reviews2018
    Dev: NitrealPub: GameHouse
    Windows · Mac

    Get ready to test your vet skills in Dr. Cares - Amy's Pet Clinic!

    Why similar: Medical Sim 82.3%, Casual 10.5%, Simulation 7.2%

  9. #9 Heart's Medicine - Hospital Heat
    91% matchVery Positive96% of 364 reviews2017
    Dev: Blue GiraffePub: GameHouse
    Windows · Mac
    Median: 5.1 hrsMean: 8.7 hrs≥1hr: 93%

    The long awaited sequel to "Heart's Medicine - Time to Heal". An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring doctor at Little Creek Hospital!

    Why similar: Medical Sim 82.6%, Casual 9%, Simulation 6%, Indie 2.4%

  10. #10 Pentamania: Alchemy Madness
    89% match3 user reviews67% of 3 reviews2025
    Dev: Athmyx
    Windows

    Step into a VR alchemy workshop, gather rare ingredients, and combine them with cauldrons, and magical machines to brew fantastical potions. Experiment, discover, and deliver your creations in an immersive fantasy experience!!

    Why similar: Medical Sim 59%, VR 19.1%, Casual 10.9%, Simulation 6.9%, Linear 2.6%

  11. #11 Valley General Hospital: NiVR
    88% match2 user reviews50% of 2 reviews2021
    Dev: Valley General
    Windows

    An exciting new approach to training and simulation in Healthcare.

    Why similar: Medical Sim 69.2%, VR 20.2%, Simulation 6.7%, 3D 3.2%, Singleplayer 0.7%

  12. #12 Heart's Medicine - Time to Heal
    86% matchVery Positive94% of 878 reviews2016
    Dev: Blue GiraffePub: GameHouse
    Windows · Mac
    Median: 6.0 hrsMean: 12.1 hrs≥1hr: 92%

    An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring surgeon at Little Creek Hospital!

    Why similar: Medical Sim 83.4%, Casual 9.4%, Simulation 4.1%, Indie 2.1%, Singleplayer 1%

  13. #13 Fun Hospital
    86% matchMixed64% of 596 reviews2018
    Dev: OrangesGame Technology Limited
    Windows · Mac
    Median: 1.2 hrsMean: 33.2 hrs≥1hr: 53%

    Build your own theme hospital! Here, you might meet patients with a lot of hair, or no hair; strange aliens, evil guy, super hero…

    Why similar: Medical Sim 78.3%, Casual 11.3%, Simulation 7.5%, Indie 2.9%

  14. #14 Real Pharmacy Simulator
    83% matchMostly Negative27% of 11 reviews2024
    Dev: Mannered Monster
    Windows

    Become the owner of a pharmacy in Real Pharmacy Simulator! Manage the business, serve customers, and balance profit with ethics. Order medicines, organize the space, and decide how to run your business - honestly or riskily. Your decisions will determine the fate of the pharmacy!

    Why similar: Medical Sim 56.6%, Idler 25.1%, Casual 6.4%, 3D 4.5%, Simulation 4.3%

  15. #15 Reanimation Inc.
    84% matchVery Positive84% of 129 reviews2019
    Dev: Dmitrii Lomakin
    Windows

    Reanimation inc is a completely realistic simulation - real urgent conditions and diseases, real protocols of care used in an ambulance, realistic simulation of the body! Do you like realistic games about medicine and simulators, games you need to think about? You 'll be happy!

    Why similar: Medical Sim 90.4%, Simulation 6.9%, Indie 2.7%

  16. #16 Medic Simulator
    84% matchNo user reviews
    Dev: Eathrabaria
    Windows

    Become a doctor and treat patients in every area of medicine. Become a cardiologist, psychiatrist, dentist, dermatologist, oncologist, surgeon, ophthalmologist, neurologist…!

    Why similar: Medical Sim 66.4%, Science 19.7%, Simulation 7.8%, 3D 5%, Singleplayer 1%

  17. #17 Kellogg's Gut Bacteria Reef
    82% matchPositive84% of 50 reviews2021
    Dev: NAKATOMIPub: KELLOGG
    Windows

    Explore the human gut like never before!

    Why similar: Medical Sim 67.3%, VR 26.5%, 3D 5.1%, Singleplayer 1.1%

  18. #18 WirtschaftsWoche Virtual Reality
    82% match3 user reviews67% of 3 reviews2021
    Dev: Michael BertramPub: Handelsblatt GmbH – ein Unternehmen der Handelsblatt Media Group GmbH & Co. KG
    Windows

    Virtual Reality Simulation Experience in Virtual Reality how an electric car is created, or save a person's life in the hospital of the future.

    Why similar: Medical Sim 48.2%, VR 29.3%, Science 18.4%, Simulation 3.2%, Singleplayer 0.9%

  19. #19 Dr Greenstuff
    81% matchVery Positive87% of 148 reviews2018
    Dev: Black DiskettePub: Black Diskette Studio
    Windows

    Discover the life of Dr Greenstuff, grow marijuana, coca, make meth', drugs and more to keep your legal/illegal business running.

    Why similar: Medical Sim 89.3%, Simulation 7.6%, Indie 3.1%

  20. #20 Vaccine Delivery Adventure
    81% matchMostly Positive79% of 14 reviews2022
    Dev: The VALIDATE Network
    Windows

    Vaccine Delivery Adventure is a classic side-scrolling action game where a healthcare worker has to overcome the challenges of delivering the BCG Vaccine to the communities that need it!

    Why similar: Medical Sim 73.8%, Science 13.8%, Casual 7.4%, 3D 4.1%, Singleplayer 0.9%

  21. #21 Sopwith VR
    79% matchVery Positive86% of 337 reviews2018
    Dev: David Mohr Gould
    Windows

    Shoot down triplanes and attack tanks with your Sopwith biplane. Simple World War One flight combat simulator with touch controls, airfoil physics, computer-controlled opponents, and destructible environments, inspired by David L. Clark's classic DOS game from 1984.

    Why similar: VR 62.9%, Flight 16.8%, Casual 11.6%, Simulation 8.7%

  22. #22 My Universe - Doctors & Nurses
    79% matchMostly Negative29% of 14 reviews2022
    Dev: It Matters GamesPub: Microids
    Windows · Mac

    Take turns to play either a doctor or nurse. Diagnose illnesses and infections so as to treat and help your many patients. Set out on an adventure in a buzzing hospital environment. Meet all sorts of different characters and discover a story full of surprises.

    Why similar: Medical Sim 79.1%, Casual 9.4%, 3D 5%, Simulation 4.9%, Singleplayer 1.6%

  23. #23 Dr. Chatelet: Faith 神医
    77% matchVery Positive85% of 131 reviews2022
    Dev: MuccyGames
    Windows · Mac

    Amputations, bloodletting, alchemy - all of which seem unthinkable today - were the treatment options that medieval doctors revered. You must face challenges one after another and experience gains and losses in the course of your constant adventures

    Why similar: Medical Sim 60.7%, Science 14.4%, Idler 13.8%, Casual 6.6%, Simulation 4.4%

  24. #24 PT+
    78% match8 user reviews88% of 8 reviews2020
    Dev: Liam McMainsPub: Axis Technologies LLC
    Windows

    Use virtual reality to learn how to stretch and exercise your neck

    Why similar: Medical Sim 52.5%, VR 23.4%, Science 15.5%, PvE 3.8%, Simulation 3.5%

  25. #25 Bacterium / 生命之旅
    77% matchPositive84% of 49 reviews2018
    Dev: Dragon Whisper GamePub: Zodiac Interactive
    Windows

    In the coming decades, a huge breakthrough in nano-medical technology will bring a new light to cure terminally ill patients. As a nano-robot operator, you will be involved in a battle between nanobots and diseases!

    Why similar: Medical Sim 89.8%, Simulation 7.2%, Indie 3.1%

  26. #26 Herbalist Simulator
    78% matchMostly Negative21% of 14 reviews2020
    Dev: EJRGames
    Windows

    Become a herbalist in a small village. Treat various diseases using natural methods. Prepare healing mixtures. Travel to search for better ingredients. Do not wait. Find your vocation to heal people…

    Why similar: Medical Sim 42.1%, VR 15.4%, Casual 14.6%, Simulation 10.5%, Science 9.9%

  27. #27 小邦迪的奇妙冒险
    76% matchPositive88% of 17 reviews2021
    Dev: Puyuan YePub: Band-Aid
    Windows · Mac

    在《小邦迪的奇妙冒险》中与小邦迪一同学习急救知识,拯救吴家于各种急症之中。

    Why similar: Medical Sim 80.3%, Casual 7.7%, Linear 4.8%, Simulation 4.8%, Singleplayer 1.3%

  28. #28 中医模拟传承人
    74% matchPositive86% of 14 reviews2024
    Dev: guizhi0011
    Windows

    A game where everyone can learn traditional Chinese medicine.

    Why similar: Medical Sim 80.1%, Simulation 8.2%, Casual 8%, Indie 2.5%, Singleplayer 1.2%

  29. #29 Dentist Simulator 2
    73% match4 user reviews100% of 4 reviews2025
    Dev: Code Lab
    Windows

    Screams, panic, and fear of the dentist’s chair — now YOU hold the drill! Master anesthesia, gum surgery, extractions, and bleeding control with precision. Go beyond basics: apply braces, craft gold & silver teeth, implants, and use inhalation sedation. Keep patients calm or hear their screams!

    Why similar: Medical Sim 55.3%, VR 20%, Casual 12%, Simulation 7.6%, PvE 3.4%

  30. #30 Scalpel, Please!
    76% matchNo user reviews
    Dev: WoolCat Games
    Windows

    Scalpel, Please! is a ridiculous medical simulator where you assist a blindfolded surgeon. Provide tools, talk to him, and give your full support. But be careful: he’ll remember everything you do and react accordingly. Will you manage to keep your job?

    Why similar: Medical Sim 73.7%, Casual 11.7%, Simulation 7.4%, 3D 5.7%, Indie 1%

  31. #31 My Universe - Pet Clinic Cats & Dogs
    75% matchMixed62% of 29 reviews2020
    Dev: It Matters GamesPub: Microids
    Windows

    Discover the veterinary profession and help cats and dogs that need you. An injury, fever, an animal that refuses to eat: it’s up to you to act!

    Why similar: Medical Sim 81.8%, Casual 9.3%, Simulation 7.7%, Singleplayer 1.2%

  32. #32 MediSim: Emergency Response
    75% matchNo user reviews
    Dev: Mehmet Hilmi Değirmenci
    Windows

    As a young doctor, save lives in emergencies, advance from a health center to a major hospital, and manage your own facility. Perform first aid, and diagnostics, take on ambulance and helicopter missions, and build your medical team. A realistic medical simulation where every decision matters!

    Why similar: Medical Sim 76.8%, Casual 10.2%, Simulation 8.1%, 3D 4%, Singleplayer 0.8%

  33. #33 GastroRun
    71% matchMostly Positive77% of 13 reviews2024
    Dev: Nuatgames
    Windows

    Gastro Run is a fast-paced educational adventure game full of obstacles, boss fights, races, withlessons placed throughout the game. You play as Gastro, a witty nano-bot whose goal is to help patients with enzyme deficiency break down food as it travels through the digestive system.

    Why similar: Medical Sim 67.4%, Flight 19.7%, Casual 7.5%, 3D 5%, Singleplayer 0.4%

  34. #34 疑義照会ウォーズ
    73% matchMostly Negative30% of 20 reviews2021
    Dev: 薬学ゲーム開発プロジェクト
    Windows

    This is a full-fledged adventure game (selectable type) based on the theme of the pharmacist's job, "checking prescription. Determine if the prescription is correct, and if it is, make a "Questionable Inquiry" to the doctor!

    Why similar: Medical Sim 91.3%, Simulation 6.3%, Singleplayer 1.3%, Indie 1.2%

  35. #35 Lucky Night: Texas Hold'em VR
    73% matchMostly Positive80% of 180 reviews2017
    Dev: ATC Games
    Windows
    Median: 1.1 hrsMean: 10.2 hrs≥1hr: 52%

    Have an enjoyable Texas hold’em game in virtual room with real players by HTC Vive or Oculus Rift.

    Why similar: VR 81.1%, Casual 18.9%

  36. #36 Highway Madness
    72% matchMostly Positive73% of 48 reviews2018
    Dev: Game Cooks
    Windows
    Median: 1.5 hrsMean: 11.4 hrs≥1hr: 51%

    Highway Madness is a social VR game where you get to play with old and new friends from all over the world! Pick your character then choose from a selection of fun games including Standoff, Road Crossing, Roof jumping and Shootout! So what are you waiting for? Come on in and join the Madness!

    Why similar: VR 79.6%, Casual 20.4%

  37. #37 Hospital Manager
    74% matchMixed46% of 254 reviews2015
    Dev: CCCPPub: Microids Indie
    Windows · Mac
    Median: 1.1 hrsMean: 9.5 hrs≥1hr: 56%

    Experience something novel, bursting with extraordinary phenomena and strange situations in your hospital! Only you have the power to make the best decisions and to make your hospital the most popular one! But beware: Several events will add some spice to your life! Embark on the career of your life!

    Why similar: Medical Sim 94.2%, Simulation 5.8%

  38. #38 Flappy Person
    72% matchNo user reviews
    Dev: POLYGONWARE
    Windows

    Ever wondered how it is to be like a flappy person? Well now you can become one.

    Why similar: VR 56.5%, Flight 15.3%, Casual 14.3%, Arcade 9.4%, Singleplayer 3%

  39. #39 Oops! INC. Emergency Center
    67% match4 user reviews100% of 4 reviews2026
    Dev: CCS
    Windows

    Run the galaxy’s most chaotic hospital in Oops! INC. Emergency Center! Play as a diploma-free robot doctor, diagnose bizarre space illnesses, craft the right remedies, and treat patients fast before insurance turns you into a fridge. Funny, frantic, and out of this world!

    Why similar: Medical Sim 83.5%, Casual 7.7%, Simulation 5.1%, Linear 1.9%, Singleplayer 0.9%

  40. #40 Endless Labyrinth
    71% matchMostly Positive75% of 20 reviews2016
    Dev: Mike Prosser
    Windows

    Endless Labyrinth is a simple, relaxing game of exploration and collection. A maze is randomly generated, forever in every direction. Hidden in the maze are lots of gems to collect! There are also special things to find while exploring, like statues or other interesting rooms.

    Why similar: VR 77.7%, Casual 22.3%

  41. #41 Isle of the Dead
    70% matchPositive81% of 47 reviews2019
    Dev: Les Produits FraisPub: Astrea
    Windows

    Step into Böcklin’s masterpiece, in an award-winning VR experience. ISLE OF THE DEAD is a timeless, fascinating journey towards our final destination, guided by Charon, ferryman of the Underworld.

    Why similar: VR 80.1%, Casual 15.2%, Indie 4.7%

  42. #42 Old Friend
    69% matchVery Positive94% of 142 reviews2016
    Dev: Tyler HurdPub: Wevr, Inc
    Windows

    Lose yourself in a vibrant and interactive psychedelic dance party brimming with joyful insanity.

    Why similar: VR 74.8%, Casual 25.2%

  43. #43 The Cable Center - Virtual Archive
    70% matchPositive80% of 20 reviews2017
    Dev: The Cable Center
    Windows

    The Cable Center is proud to announce our Virtual Reality Archives Exhibit. The Center started experimenting with virtual reality in late 2013 with the goal of capturing objects to share in exhibits and videos. Four years later, we have elevated our work to a whole new level.

    Why similar: VR 76.1%, Casual 23.9%

  44. #44 Ganbatte
    71% match3 user reviews67% of 3 reviews2018
    Dev: Mimicry
    Windows

    Ganbatte is a competitive social multiplayer arcade game for VR, about cats, in space, eating sushi. Try to eat as much valuable sushi as you can and reach the highest score.

    Why similar: VR 61.2%, Casual 19.7%, Arcade 13.1%, Indie 6.1%

  45. #45 Rexodus: A VR Story Experience
    70% matchMostly Positive72% of 120 reviews2016
    Dev: Steelehouse VR Studios
    Windows

    Rexodus: A VR Story Experience is based on the Dark Horse Graphic Novel Rexodus. This is a VR narrative experience set in a universe where dinosaurs didn't go extinct, they left Earth. Those dinosaurs, utilizing their own advanced technology, are traversing the galaxy.

    Why similar: VR 84.4%, Casual 11.9%, Indie 3.6%

  46. #46 Two Point Hospital
    65% matchVery Positive92% of 34,380 reviews2018
    Dev: Two Point StudiosPub: SEGA
    Windows · Mac · Linux
    Median: 5.5 hrsMean: 34.9 hrs≥1hr: 89%

    Design stunning hospitals, cure peculiar illnesses and manage troublesome staff as you spread your budding healthcare organisation across Two Point County.

    Why similar: Medical Sim 88.9%, Simulation 7.1%, Casual 1.9%, Singleplayer 1.2%, Indie 0.9%

  47. #47 Donor Clinic Simulator
    69% matchNo user reviews
    Dev: 2 Stula Games
    Windows

    Manage your own reproductive medicine clinic! Choose donors based on their physical traits, research the effectiveness of biomaterials, upgrade the donor room, improve your laboratory, purchase new equipment, and help couples have a baby and become happy parents!

    Why similar: Medical Sim 72.8%, Casual 11.1%, Simulation 8.8%, 3D 5.6%, Indie 1.1%

  48. #48 Psyhonds
    65% match5 user reviews80% of 5 reviews2026
    Dev: Meriteri GamesPub: Terrabyte Games
    Windows

    A satirical mental hospital survival simulator: control four unstable characters, craft from junk, forge dubious alliances, communicate with patients and staff, and choose between a quiet life in a ward, a riot, or a risky escape to freedom.

    Why similar: Medical Sim 86.3%, PvE 7.4%, Simulation 4.6%, Indie 1%, Singleplayer 0.7%

  49. #49 The Visitor
    69% matchMostly Positive76% of 210 reviews2016
    Dev: Stephen Long
    Windows
    Median: 12 minMean: 4.2 hrs≥1hr: 27%

    The Visitor is a VR horror experience about an unexpected visitor calling to your door in the middle of the night. The game relies heavily on atmosphere, utilizing a dark environment to make the player both as nervous and uncomfortable as possible.

    Why similar: VR 77%, Casual 17.8%, Indie 5.2%

  50. #50 Doctor Dash ASMR Hospital
    64% matchVery Positive90% of 93 reviews2024
    Dev: Friedegggames OUPub: Brightika, Inc.
    Windows

    💊 Your dream hospital awaits! 🏥❤️ Addictive levels and unique locations ✈️ Hours of entertainment in the time-management genre ⏰

    Why similar: Medical Sim 79.7%, Casual 11.7%, Simulation 7.1%, Singleplayer 1.5%

  51. #51 Kygo 'Carry Me' VR Experience
    68% matchPositive87% of 30 reviews2017
    Dev: MPC VRPub: Sony Music Entertainment
    Windows

    Join superstar electronic musician Kygo in this incredible virtual reality experience inspired by the hit song “Carry Me.”

    Why similar: VR 73.2%, Casual 26.8%

  52. #52 S4Game
    68% matchNo user reviews
    Dev: Viral Studios
    Windows

    S4Game aims to provide health professionals with an innovative approach to acquire soft skills to foster their professional development. Their main learning objective is the acquisition of soft skills required during work in an operating room, such as communication or teamwork.

    Why similar: Medical Sim 88.8%, Casual 3.5%, 3D 3.3%, Simulation 2.5%, Singleplayer 1.8%

  53. #53 The VR Museum of Fine Art
    67% matchVery Positive87% of 320 reviews2016
    Dev: Finn Sinclair
    Windows
    Median: 24 minMean: 6.6 hrs≥1hr: 36%

    JUST UPDATED: Explore the Second Floor of the Museum! Explore a virtual museum in room-scale VR: see famous sculptures in full, 1:1 scale and see famous paintings without the limitations of glass and security guards.

    Why similar: VR 69.1%, Casual 15.7%, Simulation 10.8%, Indie 4.4%

  54. #54 Vintage VR
    67% matchVery Positive88% of 103 reviews2016
    Dev: DunderwarePub: MuseumSyndicate.com
    Windows
    Median: 36 minMean: 8.9 hrs≥1hr: 44%

    In the 19th century, when people had no HTC Vives to play with, they resorted to using primitive stereoscopes to see stereoscopic images in 3D! This free VR experience allows you to view a collection of over 700 such images from that era and enjoy them as people saw them over a century ago.

    Why similar: VR 72.3%, Casual 27.7%

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Games Like Operation Pill

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