Games Like Protolife

An open-ended factory management game with RTS and tower defense elements.

Why similar: Tower Defense 37.6%, Base Building 31.8%, RTS 15.6%, Strategy 9.2%, Pixel Graphics 4.1%

Why You'll Like It: Combines direct builder-robot control with complex resource management and tower defense against encroaching swarms.

Command a team of 5 elite soldiers against an alien horde of 100,000. Surrounded on all sides, you must outmaneuver and outsmart the enemy.

Why similar: Tower Defense 31.9%, RTS 28%, Strategy 13.1%, Aliens 7.9%, Sci-fi 7.5%

Why You'll Like It: Requires tactical unit control to combat a rapidly spreading alien biomass on a planetary scale.

They Are Billions is a Steampunk strategy game set on a post-apocalyptic planet. Build and defend colonies to survive against the billions of the infected that seek to annihilate the few remaining living humans. Can humanity survive after the zombie apocalypse?

Why similar: Base Building 35.8%, RTS 29.4%, Tower Defense 25%, Strategy 8.9%, Singleplayer 0.7%

Why You'll Like It: Focuses on high-stakes base construction and survival against an overwhelming, encroaching swarm.

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Why similar: Tower Defense 56.1%, RTS 16.9%, Strategy 9.2%, Base Building 6.6%, Sci-fi 5.9%

Why You'll Like It: A classic entry in the series that perfectly captures the struggle against a fluid, consuming enemy.

Unique fusion of a top-down shooter and tower defense strategy. You are the invader! Use destructive weapons or lead your enemies into a maze of towers. Strategize in the build mode by carefully selecting various types of alien towers or throw yourself right into the heat of the battle.

Why similar: Tower Defense 49.5%, Aliens 16.6%, Sci-fi 11.4%, Strategy 10.6%, Top-Down 7.1%

Why You'll Like It: Blends traditional tower defense with active combat and real-time base construction mechanics.

The unstoppable fluid enemy has returned and destroyed every world in its path! Defend against Creeper as it floods across the 3D terrain in this real time strategy game where the enemy is a fluid.

Why similar: Tower Defense 37.7%, RTS 33.9%, Sci-fi 10%, Strategy 9%, Top-Down 8.1%

Why You'll Like It: Features a fluid, encroaching enemy that mimics the spreading organism mechanic found in Protolife.

The Riftbreaker is a solo or Co-op base-building, survival game with Action-RPG elements for up to 4 players. Hack & slash countless hordes of enemies. Build up your base, craft powerful weapons and research new inventions to survive.

Why similar: Tower Defense 33.5%, Base Building 32.5%, RTS 25.7%, Strategy 6.8%, Singleplayer 1.6%

Why You'll Like It: Offers direct control of a powerful mech while building and defending a base against massive alien waves.

Until We Die is a side-scrolling strategy game about defending your base where you have to run around as Ivan, assign tasks to people, and fight mutants in the post-apocalyptic subway!

Why similar: Tower Defense 34%, Base Building 29.9%, Pixel Graphics 13.2%, Strategy 11.7%, Dark 5.7%

Why You'll Like It: A side-scrolling survival strategy game that emphasizes base management and defending against encroaching threats.

Defense Grid: The Awakening is a unique spin on tower defense gameplay that will appeal to players of all skill levels. A horde of enemies is invading, and it's up to the player to stop them by strategically building fortification towers around their base.

Why similar: Tower Defense 70.8%, Strategy 10%, Sci-fi 9.4%, Aliens 6.1%, Indie 2.3%

Why You'll Like It: A quintessential sci-fi tower defense game that emphasizes strategic placement and base protection.

Build your defense base to fight back the undead hordes of Mars and secure the future of the red planet. MarZ is a game of strategy and tactical defense where you must carefully manage your crew and resources as you try to uncover the terrible secrets of the undead.

Why similar: Tower Defense 35%, RTS 27.4%, Base Building 16.4%, Strategy 10%, Sci-fi 6.5%

Why You'll Like It: Features tactical base building with a strong focus on defending against Martian threats.

Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?

Why similar: Tower Defense 39.7%, Base Building 19%, RTS 16.5%, Strategy 9.7%, Sci-fi 7.5%

Why You'll Like It: An action-heavy tower defense game where you control a powerful turret system to repel invaders.

Mechs V Kaijus is an addictive hardcore tower defense gameplay. In Mechs V Kaijus you take on the role of Commander of a powerful Mechs squadron. Improve your Mech, strategically place towers and factories on the battlefield. Deploy support units on the battlefield, and save our civilization.

Why similar: Tower Defense 72.4%, Strategy 8.5%, Base Building 7.9%, Pixel Graphics 7.1%, Indie 3.3%

Why You'll Like It: An action-oriented defense game that puts you in command of giant mechs to fight off massive creatures.

Stellar Initiative is a roguelike tower defense game where you land on the planet and use your orbit ship to deliver buildings and support you with fire. Complete missions, install new upgrades, discover powerful artifacts, and find the best strategy!

Why similar: Tower Defense 37.7%, Base Building 19.8%, Sci-fi 11.6%, Aliens 11.1%, Pixel Graphics 9.9%

Why You'll Like It: A roguelike tower defense game that emphasizes strategic positioning and intense sci-fi combat.

Get ready for the ULTIMATE tower defense onslaught. Build, deploy, research and upgrade your defenses in this epic, old school RTS inspired sci-fi adventure.

Why similar: Tower Defense 42%, Aliens 17%, Sci-fi 14.6%, Strategy 10.9%, Top-Down 9.1%

Why You'll Like It: A top-down, sci-fi tower defense game that incorporates tactical unit control and survival elements.

The ultimate mash-up of Real-time Strategy and Tower Defense!

Why similar: Tower Defense 52.9%, Strategy 10.5%, Sci-fi 7.9%, RTS 7.2%, Aliens 5.8%

Why You'll Like It: An indie tower defense game with a retro aesthetic and deep base-building mechanics.

Age of Darkness: Final Stand is a dark fantasy survival RTS where you must illuminate, build and defend humanity’s last bastion against hordes of Nightmares. Set in the remnants of a kingdom consumed by a deadly fog, you decide. Will you hide in the light? Or take back your world.

Why similar: Tower Defense 30.7%, RTS 29.3%, Base Building 22.7%, Strategy 7.9%, Dark 5.7%

Why You'll Like It: A survival-focused base defense game that pits you against massive, encroaching hordes.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Why similar: Tower Defense 46.4%, Aliens 14.3%, Sci-fi 9.4%, Pixel Graphics 8.6%, Strategy 8%

Why You'll Like It: An isometric tower defense game that captures the tactical feel of early genre classics.

Build and design the terrain while defending your stronghold against alien invasion in this unique Roguelike tower defense. Choose from 30 heroes, survive enemy waves, and upgrade a variety of destructive towers to hold the line!

Why similar: Tower Defense 32.7%, RTS 24.8%, Base Building 21.1%, Strategy 7.7%, Aliens 7.2%

Why You'll Like It: Combines tower defense with roguelike elements and base-building to create a dynamic strategic experience.

“Alien Marauder” is a real-time strategy game with survival and confrontation theme. In this game, you will be the leader to a treacherous alien planet, build and defend base to survive against the vexan waves. Make the right decision!

Why similar: RTS 25.7%, Tower Defense 21.1%, Base Building 19.1%, Aliens 10.1%, Sci-fi 9.2%

Why You'll Like It: An RTS-style base defense game that requires managing resources and surviving against alien waves.

Lead an armored squad through the perils of this reversed tower defense action-strategy game!

Why similar: Tower Defense 39.6%, Strategy 21%, RTS 13.7%, Sci-fi 11%, Aliens 6.1%

Why You'll Like It: A reverse tower defense game that emphasizes tactical movement and direct unit control.

Repel the Rifts is a roguelite tower defense game where you lead a commander through an alien world, uncovering new terrain each wave, drafting powerful upgrades, and constructing defenses to hold back the chaos.

Why similar: Tower Defense 57.7%, Sci-fi 18.9%, Strategy 10.5%, Pixel Graphics 9.7%, Indie 1.9%

Why You'll Like It: A tactical mech-based defense game that focuses on closing alien rifts through strategic construction.

Defend galaxy against Alien invasion in the RTS offline game with roguelike fun

Why similar: Tower Defense 27.2%, RTS 25.2%, Base Building 16.4%, Aliens 10.1%, Strategy 7.1%

Why You'll Like It: Real-time tactics that blends unit control with tower defense mechanics in a sci-fi setting.

'Galaxy Defense War' is a roguelike tower defense game where you need to select suitable galactic principles from randomly dropped heroes and equipment to form a combat-ready team to resist alien invaders.

Why similar: Tower Defense 42.3%, Base Building 25.6%, Strategy 15.4%, Aliens 13.6%, Indie 1.7%

Why You'll Like It: A 2D base-building tower defense game with roguelite progression and sci-fi themes.

Harvest: Massive Encounter is an award-winning real-time strategy game with battles of epic proportions and a unique style of resource management and exploration. Build power plants, mineral harvesters and defense towers and make sure they have sufficient energy to fend off endless hordes of evil aliens.

Why similar: Tower Defense 63.2%, Strategy 19.6%, Sci-fi 9.4%, Indie 6.4%, Singleplayer 1.4%

Why You'll Like It: A sci-fi tower defense game that focuses on resource management and defending against large-scale attacks.

Anomaly Defenders is the closing installment of the Anomaly series. The original incarnation of the Tower Offense sub-genre had players controlling humans fighting alien invaders. Now, the tables have turned. The human counterattack is underway and the alien homeworld is under threat.

Why similar: Tower Defense 68.6%, Strategy 20.4%, Sci-fi 5.7%, Indie 5.3%

Why You'll Like It: The tower-defense counterpart to the Anomaly series, focusing on building defensive structures to survive.

Project Astra Dominium is a Tower Defense game with Basebuilding and Automation elements. Build up your base to become a supply hub for Earth's desperately needed materials, gather resources while defending against an unknown alien threat and improve your tower's and AI capabilities.

Why similar: Tower Defense 34.9%, Base Building 25.5%, Aliens 17.2%, Sci-fi 9.4%, Strategy 8%

Why You'll Like It: Focuses heavily on the automation and crafting aspects of building a defensive base.

A tower defense action roguelike where you control a single tower to fight against hordes of aliens coming from all directions. Pick your tower, equip up to 4 skills, and choose from a variety of traits and items to craft powerful builds that lead you to victory.

Why similar: Tower Defense 37.7%, RTS 29.6%, Aliens 14.1%, Strategy 10.1%, Top-Down 7.1%

Why You'll Like It: An action-roguelike tower defense game that incorporates bullet-hell elements for a fast-paced experience.

Everwarder is a refreshing take on the tower defense genre, blending roguelite mechanics with a time-based survival concept. Fight against the encroaching darkness and fend off emerging enemies. Collect artifacts, buy upgrades, discover ancient structures, unlock new units and more!

Why similar: Tower Defense 41.4%, Pixel Graphics 11.7%, Sci-fi 11.6%, Strategy 10.7%, Top-Down 9.1%

Why You'll Like It: A roguelite tower defense game with a strong emphasis on building and survival mechanics.

Defend against waves of alien monsters in this unique roguelike action miner. Dig for resources, collect useful gadgets, and upgrade equipment to increase odds of survival – just hurry back before your dome is destroyed!

Why similar: Tower Defense 44.5%, Sci-fi 20.2%, Pixel Graphics 14.7%, Retro 10.4%, Atmospheric 6.2%

Last Outpost is a minimalist Base Building & Strategy game where you build and defend your outpost in zombie apocalypse. Choose your vehicle and loadout before embarking on your adventure. Use your abilities and control your units to eliminate all threats. Will you manage to defend your outpost?

Why similar: Tower Defense 32.9%, RTS 28.6%, Base Building 21.2%, Strategy 8.3%, Pixel Graphics 8.1%

Why You'll Like It: A city-builder and tower defense hybrid that requires careful base management to survive.

Roguelite TD: all towers & enemies start the same, but you have 1 choice per wave affecting BOTH and stacking up for dramatic variance. Gradually salvage and make some choices permanent to build deeper strategies. Also a unique mazing challenge where wires and towers must be linked to a power source

Why similar: Tower Defense 47.9%, Base Building 35.3%, Strategy 9.9%, Dark 3.4%, Indie 2%

Why You'll Like It: A base-building tower defense game that utilizes roguelite mechanics to keep each run fresh.

Build and design your own fleets and stand opposed to the Particulate in this physics/strategy/RTS/fleet hybrid. Build partially destructible and self repairing ships that interact with enemies less controlled by some scripted logic and more driven by a real time massive physics particle simulation.

Why similar: RTS 40.2%, Strategy 22.7%, Tower Defense 14.5%, Sci-fi 9.9%, Indie 6.9%

A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.

Why similar: Tower Defense 48.6%, Base Building 24%, Pixel Graphics 10.8%, Strategy 10.4%, Retro 2.9%

Rogue Tower is a tower defense game with roguelike elements and a continuously expanding path which you can influence. Unlock, build, upgrade, expand, defend.

Why similar: Tower Defense 65.5%, Base Building 19%, Strategy 14.1%, Singleplayer 1.3%

Dungeon Warfare is a challenging tower defense strategy game where you become a dungeon lord to defend your dungeons with deadliest of traps and insidious contraptions against greedy adventurers and wanna-be heroes.

Why similar: Tower Defense 48.6%, Pixel Graphics 14.4%, Strategy 12.3%, Top-Down 10.7%, Retro 7.5%

TOWER ▪ DEFENSE ▪ STRATEGY. Control Vessels. Utilize their uniquely deep set of towers. Create an everchanging defense. Play with friends. Protect your Basin at all costs. An absolute Tower Defense, Real-Time Strategy Hybrid

Why similar: Tower Defense 33.5%, RTS 32.2%, Base Building 14.8%, Pixel Graphics 8.6%, Atmospheric 4%

Mech Fortress is a sci-fi tower defense game where each turret has unique mechanics. You can freely place them on a 5×5 grid, and your goal is to eliminate all enemies!

Why similar: Tower Defense 60.3%, Strategy 13.1%, Sci-fi 10.8%, Top-Down 7.2%, Pixel Graphics 7.2%

We fused deck-building roguelikes and tower defenses in a way never seen before - deploy your towers, collect valuable trinkets and cast powerful spells to defend yourself against the Salkoth!

Why similar: Tower Defense 52.8%, Sci-fi 13%, Strategy 10.7%, Pixel Graphics 10.2%, Top-Down 8.8%

A dark sci-fi mech assembling manager with semi-auto battles against mutating, alien bio-weapon.

Why similar: RTS 46.7%, Pixel Graphics 22.9%, Strategy 21.4%, Indie 6.6%, Singleplayer 2.5%

Your village must survive for 13 days! Gather resources, expand, explore the underground for riches, and train soldiers to defend against hordes of the undead.

Why similar: Tower Defense 33.8%, Base Building 24.9%, RTS 24.5%, Strategy 9.8%, Pixel Graphics 3.7%

Corporate greed meets strategic planet-mining in Drill Core! Drill to the heart of planets while managing workers, researching cutting-edge tech, and fortifying against alien attacks. Will you prioritize efficiency and risk your workers' safety, or focus on defense for survival?

Why similar: Tower Defense 41.7%, Base Building 26.4%, Strategy 12.6%, Sci-fi 9.1%, Aliens 9.1%

Epic sci-fi tower defense action with 16-bit era look and feel, pitching your colonists against an almost endless horde of hostile alien robots who strongly oppose your attempts of colonizing their planet! Deluxe version includes the soundtrack!

Why similar: Tower Defense 62.1%, Strategy 28.4%, Indie 9.5%

YORG.io is a game with an original twist on supply chains and zombies. Your goal is to build a base which survives the night which is when zombies attack. Build and upgrade defensive towers to protect your base and try to survive as long as possible.

Why similar: Tower Defense 54.8%, Strategy 20.7%, Base Building 18.2%, Indie 6.4%

Gnomes is a turn-based tower defense with deep roguelike progression, set in ever-expanding, procedurally generated biomes. Build, farm and defend your village as you push deeper into goblin-infested territory. Unlock powerful upgrades and craft your environment to survive the endless goblin horde

Why similar: Tower Defense 43.9%, Base Building 24.1%, Pixel Graphics 10.8%, Strategy 8.4%, Dark 7.2%

Command your own fortress in FTL-like real-time battles! Crush the enemy fortress with unrelenting bombardment or seize it with carefully executed invasion.

Why similar: Tower Defense 41%, Base Building 27.5%, Strategy 23.6%, Indie 6.1%, Singleplayer 1.9%

This is a strategy game that combines tower defense with Roguelike. Unlike traditional tower defense game, the towers in the game are vehicles that move along ‘loops’.You need to create defense loop and build battle trains to defend against enemy attacks.

Why similar: Tower Defense 33.2%, RTS 28.3%, Base Building 18.2%, Strategy 9.4%, Top-Down 6.2%

From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.

Why similar: Tower Defense 31%, RTS 30.5%, Base Building 24.9%, Strategy 7.1%, Pixel Graphics 6.4%

Let Them Come is a fast paced pixel art shoot ‘em up. Twitchy trigger fingers and focused battle tactics are the order of the day as wave after wave of alien-like creatures try to take you down.

Why similar: Tower Defense 39.7%, Aliens 18.6%, Pixel Graphics 13.1%, Sci-fi 8.4%, Strategy 5.9%

Land on a planet, pick up some rocks, leave before the solar system explodes. Oh, and don't die in the nightly robot attacks! Freaking Meatbags is a humorous real-time strategy game that's all about building a base, mixing meatbag DNA, then convincing those dolts to help you gather resources.

Why similar: Tower Defense 37%, RTS 20.7%, Strategy 13%, Base Building 10.5%, Pixel Graphics 8.2%

Collect resources and establish a defense line before dark And then Facing countless enemies

Why similar: Tower Defense 48.3%, Base Building 25.4%, Strategy 11.9%, Top-Down 10.4%, Indie 2.3%

A strategic fusion of automation game and tower defense

Why similar: Tower Defense 53.4%, Strategy 15.6%, Sci-fi 14.1%, Pixel Graphics 12.7%, Indie 2.6%

Defend Billy and his crew on their way to the extraction zone! You have been authorized to use the defense system. Protect them from giant bugs, malfunctioning droids and more...

Why similar: Strategy 27%, Sci-fi 26.7%, Aliens 21.3%, Tower Defense 11.2%, Indie 9%

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

Why similar: Tower Defense 44.9%, Sci-fi 12.9%, Pixel Graphics 12.5%, Strategy 10.6%, Top-Down 7.9%

Space Run is a «real-time spaceship construction strategy game». Space Run takes the well-known Tower Defense-style gameplay and twists it, challenging you to manage and protect a spaceship and its cargo against the hazards of deep space!

Why similar: Tower Defense 70.8%, Strategy 14.8%, Sci-fi 10.3%, Indie 3.3%, Singleplayer 0.8%

Phoenix Hope is a pixel art 2D real-time, side-view strategy game in which you must develop your colony during the day and repel waves of monsters at night.

Why similar: Tower Defense 27.3%, Base Building 22.6%, RTS 22.3%, Pixel Graphics 10.7%, Strategy 9.7%

Defend your base against increasingly dangerous enemy waves each night in this minimalist survival strategy. Mine resources, build and repair defenses, and upgrade your structures, tools, and abilities to survive in this harsh world.

Why similar: Tower Defense 40.7%, Base Building 29%, Strategy 15.7%, Pixel Graphics 11.4%, Atmospheric 2.6%

Ancient Planet is classic tower defense game. The stronghold of an ancient civilization has been invaded by hordes of alien raiders. Use powerful technologies of the Ancient and repel the attack of the enemy's armies!

Why similar: Tower Defense 80.8%, Strategy 13%, Indie 4%, Atmospheric 2.2%

Employ lethal turrets, traps, and gadgets to defend against an onslaught of evolving creeps! Step into a twisted, hyper 3D, mind bending realm. Upgrade and adapt your defenses. Become a master maze crafter. Collect bizarre artifacts. Rush creeps for lucrative rewards, and succumb to greed!

Why similar: Tower Defense 51.4%, Aliens 18%, Sci-fi 15.9%, Strategy 12.1%, Singleplayer 2.6%

Firebase Defence is a new spin on the traditional tower defence gameplay. You have to defend yourself from the waves upon waves of incoming enemies. You are free to build, place and manage your available resources and units in any way you want. But failing to balance those will result in defeat!

Why similar: Tower Defense 36.4%, Base Building 21.1%, RTS 16.5%, Strategy 13.1%, Top-Down 5.3%

DEFENSURVIVOR is a strategy game where you build obstacles and place and move units to block zombies. There are various units with unique characteristics and powerful high-level units that can be obtained through combination. Use randomly given units to survive until the end!

Why similar: Tower Defense 32.2%, RTS 28.2%, Base Building 23.7%, Strategy 7.3%, Top-Down 6.6%