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Games Like Plague Doctor: Life in Pestilence

60+ similar titles based on shared tags and player behavior. Themes include Simulation, Singleplayer, Management, 3D.

Plague Doctor: Life in Pestilence header art

From an unknown quack to a reputable Plague Doctor, watch the plague unfold before your eyes. Gather ingredients, brew remedies, expand your clinic, and perform surgeries alone or up to 4 player co-op. Will you uphold the Hippocratic Oath... or watch the world rot and darken with every death.

Reviews: No user reviews — 50%
Released: Coming soon
Developer: PST Games
Genres: Adventure, Indie, Simulation
Platforms: Windows

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    97% matchNo user reviews
    Dev: 2 Stula Games
    Windows

    Manage your own reproductive medicine clinic! Choose donors based on their physical traits, research the effectiveness of biomaterials, upgrade the donor room, improve your laboratory, purchase new equipment, and help couples have a baby and become happy parents!

    Why similar: Medical Sim 41.9%, Management 12%, Simulation 10.2%, Economy 8.3%, Immersive Sim 7.4%

  2. #2 Antidotera
    96% matchNo user reviews
    Dev: Forest Initiative
    Windows

    Dive into the role of a researcher on a dangerous, resource-rich island. Gather rare ingredients, craft life-saving potions, and survive the wild. Uncover secrets and send cures back to the government to combat a deadly epidemic haunting the population.

    Why similar: Medical Sim 28%, Crafting 10.3%, Immersive Sim 9.6%, Life Sim 8.8%, Nature 8.4%

  3. #3 Pharmacy Simulator
    96% matchMixed60% of 242 reviews2024
    Dev: Altai Entertainment
    Windows

    Experience a realistic pharmacy management experience with Pharmacy Simulator. Set up your shop, decorate it as you wish, and purchase over a hundred types of medications. Pharmacy Simulator offers you an incredibly realistic pharmacy experience. Prove your skills in a challenging economic system.

    Why similar: Medical Sim 39.6%, Immersive Sim 12.9%, Life Sim 12.8%, Simulation 9.2%, Economy 8.2%

  4. #4 Medieval Dynasty
    95% matchVery Positive91% of 49,970 reviews2021
    Dev: Render CubePub: Toplitz Productions
    Windows
    Median: 11.7 hrsMean: 35.7 hrs≥1hr: 91%

    Hunt, survive, build and lead in the harsh Middle Ages: Create your own Medieval Dynasty and ensure its long-lasting prosperity or die trying! Play alone or team up with friends to enjoy the ultimate medieval experience.

    Why similar: Crafting 14.5%, Building 12.2%, Medieval 10.7%, Co-op 9.1%, Immersive Sim 9%

  5. #5 Fire Station Renovation
    94% matchNo user reviews
    Dev: FrogVille Games
    Windows

    FIRE STATION RENOVATION is a renovator simulator for abandoned and forgotten fire stations. Buy old hovels, repaint, redecorate, clean and even build rodent traps and bring the firehouse back to life!

    Why similar: Medical Sim 36.1%, Immersive Sim 12.2%, Base Building 11.3%, Life Sim 11%, Building 7.9%

  6. #6 Store Life Simulator
    94% matchNo user reviews
    Dev: Insight Game StudioPub: Hibull Games
    Windows

    Store Life Simulator is a simulation and management game where you start with a small grocery store and have to expand it until you create a true business empire! Hire employees, manage your stock, serve customers and open new stores while facing the daily challenges of an entrepreneur.

    Why similar: Medical Sim 39.4%, Immersive Sim 13%, Economy 12.4%, Life Sim 11.7%, Simulation 7.6%

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    93% matchNo user reviews
    Dev: GamesUP StudioPub: T-Bull
    Windows

    Become a one-man renovation company and take care of the reconstruction of a ruined hospital! Save a neglected facility and create a fully functional emergency complex. The entire process of cleaning, planning, repairing, and arranging is on your side. Build a dream clinic in the Hospital Renovator!

    Why similar: Medical Sim 44.2%, Life Sim 10.1%, Building 9.9%, Management 8.1%, Immersive Sim 7.7%

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    91% matchMixed56% of 196 reviews2023
    Dev: Crystalia GamesPub: CreativeForge Games
    Windows

    With Music Store Simulator you can lead a musical instruments manufacturing company. Create, sell, earn and reinvest improving and developing your business. Expand your Brand and climb to success in order to become the world's largest manufacturer of musical instruments!

    Why similar: Economy 16.5%, Crafting 15.2%, Management 14.8%, Simulation 13.6%, Immersive Sim 12.4%

  9. #9 Monastery Builder
    91% matchNo user reviews
    Dev: SolidGames
    Windows

    Become a monk in a medieval European monastery. Be diligent with your duties, and develop and expand your friary. Learn plenty of useful skills and contribute to raising the standard of living for the local community.

    Why similar: Immersive Sim 12.6%, Medieval 11.3%, Economy 11.2%, Base Building 10.3%, Crafting 10.1%

  10. #10 SAELIG
    92% matchVery Positive86% of 1,077 reviews2017
    Dev: Atorcoppe Games
    Windows · Mac · Linux
    Median: 1.8 hrsMean: 12.6 hrs≥1hr: 60%

    SÆLIG is a game that blends together elements of simulation, strategy, RPG, and business management. Centred around the life of you and your family, you must try to survive and bring wealth and prosperity to your household.

    Why similar: Medical Sim 18.5%, Economy 13.3%, Medieval 12.5%, Management 9.6%, Crafting 9.1%

  11. #11 Kingdom Of Peace
    89% matchMixed48% of 25 reviews2025
    Dev: Prosuntal Games Studio
    Windows

    In Kingdom of Peace you play as Racław, a hero who faces war, danger and difficult decisions. Explore medieval kingdoms, engage in intrigue, fight and create your own destiny, and finally create your own settlement!

    Why similar: Medieval 15.4%, Life Sim 12.4%, Historical 10.5%, Management 10%, Building 9.7%

  12. #12 Two Point Hospital
    90% matchVery Positive92% of 34,380 reviews2018
    Dev: Two Point StudiosPub: SEGA
    Windows · Mac · Linux
    Median: 5.5 hrsMean: 34.9 hrs≥1hr: 89%

    Design stunning hospitals, cure peculiar illnesses and manage troublesome staff as you spread your budding healthcare organisation across Two Point County.

    Why similar: Medical Sim 60.9%, Management 15.7%, Building 12.5%, Simulation 9.8%, Multiplayer 1.1%

  13. #13 Coin Maker Simulator
    89% matchNo user reviews2026
    Dev: Studio 312
    Windows

    Enjoy the hands-on crafting process in this immersive, relaxing simulator about making money. You’ve been locked in a dungeon, and your only way to freedom is to do what you do best: craft coins for the King!

    Why similar: Immersive Sim 19.8%, Crafting 17.2%, Economy 16.6%, Medieval 13.6%, Management 12.4%

  14. #14 Paramedics! - EMS Simulator
    88% matchNo user reviews
    Dev: Takendsim
    Windows

    First of its kind emergency medicine simulator, bringing the option for players around the world to try, learn, and experience what it takes to be in emergency medical services, featuring in-depth and real-life systems, and a responsive human body. You choose what protocols to follow.

    Why similar: Medical Sim 44.7%, Immersive Sim 12.4%, Crafting 10.2%, Management 9.6%, Choices Matter 6.1%

  15. #15 Blacksmith's Kingdom
    87% matchNo user reviews
    Dev: HinkoStudio
    Windows

    A fantasy blacksmith shop simulator with survival-crafting gameplay. Start as a small-town blacksmith and forge your way to the throne. Craft powerful swords, expand your workshop, and gather rare resources. Defeat powerful enemies and prove your strength in the mines and at the forge.

    Why similar: Co-op 14.7%, Management 12.8%, Crafting 12.2%, Simulation 11.7%, Open World 10.3%

  16. #16 Lifeguard Simulator
    86% matchNo user reviews2026
    Dev: FreeMind S.A.
    Windows

    Guard the beach, react fast, and save lives using quads, jet skis, motorboats, drones, and a helicopter. Patrol the bay, help those in need and uncover a hidden criminal intrigue beneath the waves.

    Why similar: Medical Sim 42.6%, Immersive Sim 12.9%, Life Sim 10.6%, Open World 7.3%, Choices Matter 7.1%

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    86% matchNo user reviews2026
    Dev: Tas Simple Games
    Windows

    You are a simple peasant living in medieval times, working for your feudal lord. One day, you discover the recipe for brewing beer. This changes your life - improve your brewing skills, unlock new sales channels, and expand your product across growing territories.

    Why similar: Economy 14.7%, Management 14.1%, Crafting 13.9%, Medieval 13.2%, Building 12.7%

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    84% matchMixed62% of 652 reviews2025
    Dev: Soi GamesPub: Red Axe Games
    Windows

    Banker Simulator is a single-player game where you revive a bankrupt bank. With active and passive (idle) gameplay, make strategic decisions to grow your bank, satisfy customers, and tackle financial crises.

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    85% match2 user reviews100% of 2 reviews2024
    Dev: vadsl05
    Windows

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    Dev: Bleeding Edge StudioPub: Blackburne Games Studio FZ LLC
    Windows

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    83% matchNo user reviews
    Dev: Goosix Games
    Windows

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    Why similar: Co-op 14.6%, Management 13.7%, Crafting 12.5%, Immersive Sim 11.4%, Simulation 10.6%

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    Windows

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    82% matchMixed57% of 30 reviews2024
    Dev: Eathrabaria
    Windows

    You live in a small soviet slav eastern european cyberpunk city. You have severe heroin addiction that you need to sustain. Heroin is very expensive and earnings in a rural city are very small, barely enough for survival. Survive one week.

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    79% matchMostly Positive75% of 485 reviews2025
    Dev: SolidGamesPub: Big Cheese Studio
    Windows

    Plan, build, and unwind in medieval China. Lead villagers, fine-tune production, and craft iconic Chinese landmarks brick by brick. Roam passes, deserts, and river valleys; farm, cook, and decorate. Master new crafts, earn imperial favor, and turn smart design into lasting legacy.

    Why similar: Historical 14.5%, Crafting 14.1%, Medieval 13.7%, Immersive Sim 11.3%, Building 10.6%

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    79% matchMostly Positive75% of 7,351 reviews2024
    Dev: SuperkamiPub: Toplitz Productions
    Windows
    Median: 7.1 hrsMean: 15.6 hrs≥1hr: 85%

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    Why similar: Base Building 12.4%, Medieval 11.8%, Life Sim 11%, Crafting 10.6%, Historical 10.5%

  26. #26 BirdsBorough : Town of Alchemy
    81% match7 user reviews86% of 7 reviews2023
    Dev: Madamé Pigeon Games
    Windows · Mac

    Build and run your own alchemy store, make your own unique custom potions and learn the stories of the residents, in the ominous town of BirdsBorough...

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    77% matchVery Positive86% of 81 reviews2026
    Dev: Zentium Studio
    Windows · Linux

    Team up with your friends and build a thriving trade empire in this CO-OP strategy and economy simulation set on a lively island. Begin with a small market, share tasks, manage production chains, raise livestock, and dominate the economy together through changing seasons and dynamic festivals!

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    78% matchNo user reviews
    Dev: ZD Games
    Windows

    Smart Lab: Build your lab from the ground up, research new recipes, optimize production chains, and craft valuable products. Produce in batches, improve quality, and sell your results to keep expanding.

    Why similar: Medical Sim 30.3%, Crafting 17%, Base Building 14.2%, Life Sim 10%, Simulation 7.4%

  29. #29 Pharmacy Store Simulator
    78% matchNo user reviews
    Dev: Art Games Studio S.A.
    Windows

    Run your own Pharmacy! Sell medicines, advise customers, validate prescriptions, and fulfill them. Start small and expand your business - make it big in the medicine world!

    Why similar: Medical Sim 23.7%, Economy 16.1%, Management 13.8%, Simulation 11.2%, Immersive Sim 11.1%

  30. #30 Hospital Manager
    81% matchMixed46% of 254 reviews2015
    Dev: CCCPPub: Microids Indie
    Windows · Mac
    Median: 1.1 hrsMean: 9.5 hrs≥1hr: 56%

    Experience something novel, bursting with extraordinary phenomena and strange situations in your hospital! Only you have the power to make the best decisions and to make your hospital the most popular one! But beware: Several events will add some spice to your life! Embark on the career of your life!

    Why similar: Medical Sim 69.7%, Management 21.6%, Simulation 8.7%

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    76% matchNo user reviews
    Dev: Reminiscent Realms Studio LLC
    Windows · Linux

    In this life-sim, you are sent by the adventurer’s guild to run a local infirmary. Explore diverse biomes to gather ingredients, nurture your herbs and concoct remedies to aid your guild. Build relationships with your neighbors and engage in community events.

    Why similar: Medical Sim 37%, Life Sim 13.2%, Management 10.7%, Crafting 10.1%, Immersive Sim 9.8%

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    75% matchMostly Positive76% of 17 reviews2026
    Dev: Xeirel Software
    Windows

    Run a marketplace where you can sell games and everything related, take care of customers and shape it however you want.

    Why similar: Economy 14.2%, Immersive Sim 14.2%, Life Sim 13.8%, Building 10.4%, Management 9.9%

  33. #33 Pirate's Den Renovator
    76% matchNo user reviews
    Dev: Space Boat StudiosPub: PlayWay S.A.
    Windows

    Help a devastated harbor bay get back on its feet just after being attacked and burned down. Rebuild, renovate and expand your new stationary business. Attract as many customers as possible, take care of the supply chain and micromanage workshops to become the greatest retired pirate ever!

    Why similar: Economy 14.6%, Base Building 13.2%, Building 11.5%, Immersive Sim 10%, Crafting 9.2%

  34. #34 Fuel Station Simulator
    75% matchNo user reviews
    Dev: glass Pixel Games
    Windows

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    Why similar: Economy 17.5%, Life Sim 16.4%, Immersive Sim 14.7%, Management 13.6%, Simulation 9.1%

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    73% match7 user reviews14% of 7 reviews2026
    Dev: Single Soul Studios
    Windows

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    74% matchNo user reviews
    Dev: OA Game Studio
    Windows

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    Why similar: Medical Sim 40.8%, Immersive Sim 11%, Life Sim 10.6%, Economy 9.9%, Crafting 6.9%

  37. #37 Valley General Hospital: NiVR
    77% match2 user reviews50% of 2 reviews2021
    Dev: Valley General
    Windows

    An exciting new approach to training and simulation in Healthcare.

    Why similar: Medical Sim 58.5%, Immersive Sim 14.4%, Simulation 11.4%, Realistic 8.1%, Choices Matter 5.1%

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    73% matchNo user reviews
    Dev: Junkman SimulatorPub: Weakfish Studio
    Windows

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  39. #39 Waterpark Simulator
    71% matchOverwhelmingly Positive96% of 9,416 reviews2025
    Dev: CayPlay
    Windows
    Median: 9.5 hrsMean: 14.6 hrs≥1hr: 92%

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    Why similar: Immersive Sim 16.4%, Economy 13.1%, Crafting 11.3%, Base Building 11.3%, Management 11.1%

  40. #40 Beach Bar Simulator
    73% matchNo user reviews
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    Windows

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    Why similar: Immersive Sim 14.6%, Crafting 14.1%, Economy 13.9%, Nature 11.6%, Building 10.8%

  41. #41 Self Made Man: Life of an Entrepreneur
    72% matchNo user reviews
    Dev: Sirhyss Studio
    Windows · Mac · Linux

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    Why similar: Immersive Sim 13.7%, Economy 13.4%, Management 12.2%, Life Sim 11%, Crafting 10.4%

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    71% matchMostly Positive76% of 87 reviews2025
    Dev: AMGames TC
    Windows

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    Why similar: Medical Sim 47.8%, Medieval 13.8%, Economy 11.1%, Management 10.9%, Simulation 6.9%

  43. #43 Timberflow: Sawmill Simulator
    71% matchNo user reviews
    Dev: HatchStudio
    Windows

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    Why similar: Economy 13.3%, Management 12.5%, Base Building 11.8%, Crafting 11.7%, Nature 9.2%

  44. #44 Psyhonds
    70% match5 user reviews80% of 5 reviews2026
    Dev: Meriteri GamesPub: Terrabyte Games
    Windows

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    70% matchMixed65% of 60 reviews2025
    Dev: QuantumPlay Studios
    Windows

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    Why similar: Economy 15.1%, Base Building 12.6%, Life Sim 12.3%, Building 11.9%, Crafting 10.3%

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    70% matchMixed48% of 27 reviews2024
    Dev: Lost Nexus StudioPub: Lost Nexus
    Windows

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    Why similar: Economy 17.4%, Open World 13.5%, Immersive Sim 13.1%, Life Sim 13.1%, Management 13%

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    69% matchMixed51% of 1,195 reviews2025
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    Windows
    Median: 2.0 hrsMean: 4.6 hrs≥1hr: 71%

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    Why similar: Medical Sim 51.7%, Open World 10.6%, Simulation 10%, Realistic 8.3%, Immersive Sim 8%

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    68% match3 user reviews67% of 3 reviews2025
    Dev: びゅびゅ丸★
    Windows

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    69% matchMostly Positive77% of 360 reviews2023
    Dev: Crystalia GamesPub: PlayWay S.A.
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    Median: 1.0 hrsMean: 13.6 hrs≥1hr: 48%

    With Music Store Simulator Prologue you can lead a musical instruments manufacturing company. Create, sell, earn and reinvest improving and developing your business. Expand your Brand and climb to success in order to become the world's largest manufacturer of musical instruments!

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    68% matchMostly Positive71% of 249 reviews2024
    Dev: Games Incubator
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    Median: 42 minMean: 3.4 hrs≥1hr: 33%

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    Why similar: Nature 15.5%, Management 14.2%, Life Sim 12.5%, Immersive Sim 12.4%, Building 11.7%

  51. #51 Real Pharmacy Simulator
    68% matchMostly Negative27% of 11 reviews2024
    Dev: Mannered Monster
    Windows

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    Why similar: Medical Sim 48%, Life Sim 14%, Management 8.5%, Economy 8.4%, Simulation 7.4%

  52. #52 Plaquist Simulator
    67% matchNo user reviews
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    Windows

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  53. #53 Noble's Life: Kingdom Reborn
    67% matchNo user reviews
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    Why similar: Historical 13.5%, Medieval 13.5%, Economy 11.4%, Base Building 11.2%, Building 9.8%

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    66% matchNo user reviews
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    65% match8 user reviews88% of 8 reviews2025
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    66% matchMixed70% of 76 reviews2024
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  57. #57 Gigmaker
    66% matchNo user reviews
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Games Like Plague Doctor: Life in Pestilence

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