Top Outbreak Sim Games

Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.

The post-apocalyptic dark comedy is back - remastered and even more radioactive than before! Scavenge supplies, rescue your family, and stay alive in your fallout shelter. Make difficult decisions, hunt mutant roaches... and maybe survive. Or not.

60 Seconds! is a dark comedy atomic adventure of scavenge and survival. Collect supplies and rescue your family before the nuke hits. Stay alive in your fallout shelter. Make difficult decisions, ration food and hunt mutant cockroaches. And maybe survive. Or not.

A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding.

Quarantine is an intense turn-based strategy game about waging war on pandemic disease. Recruit a team of specialized operatives to deploy on worldwide missions. Research the contagion, upgrade your tech, and quarantine the outbreak before it kills us all.

Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?

Become a parliamentarian, create a powerful party, and lead it to victory in this humorous adventure game. Manage your popularity and dignity, use unique powers, and navigate a storyline inspired by current events.

DeadOS is an early access zombie outbreak simulator by Benn Powell that focuses on city-wide scenarios where you have access to fully customize your apocalypse experience from beginning to end. Simulation. Sandbox. Survival!

ICBM is a real-time strategy game of nuclear destruction. Research new technologies, build up your nuclear stockpile and use a combination of ships, planes and missiles to strike at the heart of your opponents’ cities while keeping your population safe from harm.

Can you rebuild civilisation after a zombie apocalypse? From the creator of Plague Inc. comes a unique blend of strategic simulation, survival city builder and ‘mini 4X’. Build settlements, harvest resources and shape society as you lead Humanity out of the darkness.

Discover a post-apocalyptic world Collect resources and manage people Build your colony on the remains of an oil tanker Prepare supplies and vehicles for a dangerous expedition. Complete challenging tasks from the council of elders

Take on the role of a Dark Elder God and lead your agents to bring about an apocalypse in a fantasy world. Work in the shadows, avoiding the heroes who will try to stop you, as you bring about plague and famine, ice age and volcanic destruction, madness and never ending night.

Live the experience of being a powerful god and create the world to see the growth of mankind.

The Fabulous Fear Machine is a narrative-driven strategy game with a pulp horror style. As the Machine's new Master, you must sow fear and expand your influence by creating Legends, harvesting resources, manipulating events, and spying on your enemies.

Will you be able to infect all devices of the world? «Trojan Inc.» - simulator, which will involve you in a world of computer viruses and trojans.

Evil Labs is a game about building and managing your own Evil Laboratory. Research and develop diseases, infect people, sell the cure and get rich!

Become an inspector examining causes of plane crashes. Visit the crash site, gather evidence and interrogate witnesses. Explain whether the accident was caused by independent factors or human errors.

Kill everyone in the world with a guillotine… on a cursed Win98 desktop.

Manage an ER during the apocalypse, solo or with friends online: diagnose patients, design and grow your hospital, and defend against the undead while treating the living. Integrate with Twitch chat for even more fun!

In the game, day and night alternate. Zombies will not be active during the day, so you can build your home with confidence. But at night you have to resist hordes of zombies and guard your camp!

Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams.

Survive the Zombies War in this RPG game of Apocalypse and Survival

War of the Zombie brings together the best of turn-based simulation and real-time strategic gameplay action across the entire world at the very start of a mysterious undead outbreak.

Afterinfection is a brand new zombie survival game designed in Unreal 4 and being developed by a small team from Thailand. After creating your survivor, you’ll start with nothing and have to make your way across a large island searching for food, water, weapons, and crafting supplies.

Dive into Project L33T, a hardcore first-person tactical extraction shooter. Confront AI foes and rival players, engage in high-stakes battles for precious loot, and risk it all in this hostile environment. Die and lose all of your gear and loot.

Hit the pedal, run out the offroad.

Play as the zombies! Infect and Destroy is an indie game in which you play as an infectious disease with the sole purpose of eliminating everyone on Earth. Play as an ultra-intelligent self-aware virus capable of reanimating the dead and turning them into your minions.

In Walking Survival, the darkness is closing in, and monstrous creatures are coming for you! Harness the power of magic, develop unique abilities, and obliterate waves of enemies before they overwhelm you.

In 'Evotinction', a third-person hacking and stealth game, you are Dr. Liu, the only one who can stop rogue AIs in a futuristic research facility. Use a variety of hacking skills to overcome robotic threats and uncover the secrets that hold the key to humanity's survival or its potential extinction.

Perfect Heist is a round-based online game, where the robber team tries to execute a bank robbery without getting noticed, and the cop team tries to prevent it. Robbers hide in plain sight and try to slowly infiltrate the bank while the Cops try to figure out who is a normal customer, and who is a robber!

This Is the President is a political thriller. You are the newly elected leader with a shady background. It is up to you to abuse the position of the most powerful man in the world to escape justice for past crimes – even if that pitches the country into utter chaos.

40 Days is a special strategy simulation game related to infectious diseases spread all over the city. You, as ahead of the quarantine department, have been given full authority and manpower to contain the city, deal with different parties, virus in the city and most importantly find out the cure.

You are locked inside a cinema. Your only way to escape is to follow the instructions of your task: Watch the same film clip repeatedly and search for flaws to break free. But this may sound easier than it is, every wrong decision or death will set you back. So be careful!

A world where you can create your own zombie apocalypse to your liking!

Explore infinite possibilities with INFINITE LIVES - where superhumans and subhumans fight for control of the ultimate shared universe! Bursting into the 3rd dimension brings new powers with unprecedented freedom, in a vicious cycle that never ends...

A first-person shooter meets quarantine inspection in post-apocalyptic Chicago. You’ve got 30 days until the army arrives. Hold out, fix your car, and fight your way through Chicago to the main checkpoint to save your little brother.

Dive into the heart of aviation mysteries in "Plane Accident: Prologue." Explore realistic crash sites, analyze evidence, and solve puzzles. Unveil the truth in this thrilling prelude to the full "Plane Accident" experience.

A Huge Wave of Zombies Are Coming! Control hundreds of swarming zombies to conquer the entire city!

You play as a salaryman who gets caught in various everyday troubles and overcomes them with acrobatic bows. From boss reprimands to client complaints and family issues, showcase your elegant apology skills across different scenarios. What shocking ending awaits?

WARNING. Stay inside. Lock your doors. Close the blinds. Only let humans in. Eliminate all Visitors. An anxiety horror about paranoia in the End of Times.

You will have to visit the patient's apartment, find out about the agent's disappearance and submit a report to VGL Corporation. The task is easy, but after you enter the apartment, the picture will change and only the goal will remain - to survive!

THE SHRiNK is an AVN. You play as Alex (default name) you can choose your name, and the names of the rest of the main cast. You can also choose your relationship with them from the very start of the game. Choices in this game will decide the type of content you see or miss out on.

Virus Petya - a simulator of the system administrator. In this game you need to run from one computer to another, to remove from the computer a terrible virus "PETYA". But it's not easy, because with each attempt of the virus to infect the computer, the virus gets closer to the end of his successful work

COVID: The Outbreak is a real-time strategy game in which you play the role of a global organization that has to deal with a global pandemic. Issue decrees, manage resources, develop projects, and construct buildings. A race for the vaccine begins!

Undead Inc. is a high-risk, high-reward resource management simulator where you establish and manage a local subsidiary of the Endswell Medical Corporation. Build, manage staff, conduct research, and trade in both cutting edge medical treatments and bleeding edge bioweapons.

Erotic text-based adventure of blue alien women, parasites, and spaceships.

Sweet raging fast zombie revenge!

COVID SIMULATOR is an outbreak simulation that visualizes how quickly Covid-19 spreads, becoming a disaster. The game is an open sandbox where you can add (or remove) Covid mandates and see what happens! Create your workplace, enact your mandates, and roll the dice with your workers.

A free, first-person, short medical horror experience that is an early rendition of the prequel we envisioned for Negative Atmosphere.

Distancing is a social distancing game where you are going to a party, but on the way you need to try and keep the social distancing.

Zombies Attack is a retro pixel horizontal action game. You will face a large number of zombies and bosses in the doomsday. Pick up your weapons and fight your way out of the zombies! !

Inspired by Max Brooks' World War Z novel, Z-Collapse takes you into a worldwide zombie apocalypse. As leader of the government of your choosing, make sure your country survives! Dramatic decisions are ahead of you. How do you manage them?

《中国战疫》是一款科普防疫知识的模拟经营类游戏，玩家将临危受命地前往不同地区进行疫情控制，展示中国防疫的成功经验，最终达成疫情控制和经济稳定的双赢。

Created by Randel Reiss Kill or Be Killed If this 3D game doesn't your adrenaline pumping, nothing will. Zero Tolerance has you killing alien terrorists who want to annihilate your defense colony.

Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!

See how long you can survive in a world full of brainless zombies and heartless humans! Find your place among hundreds of other characters spread across several warring factions, and battle to reclaim every corner of a sprawling city in real-time.

Choose any real region from the world. Choose your base of operations, then rebuild and readapt the buildings around you to create a self-sustaining settlement. Take charge of a group of survivors from your city. And when the night falls - Defend the zone from the infected!

Extremely realistic simulator with unprecedented features that let you finally vent all the anxiety modern world induces in you.