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Games Like Project: Vaccine A

60+ similar titles based on shared tags and player behavior. Themes include Tower Defense, Strategy, Singleplayer, 2D.

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  1. #1 Toast Defense
    97% matchVery Positive85% of 220 reviews2020
    Dev: Egghead Interactive LLC.
    Windows

    Ducks are after your toast! Setup various water guns in this fun tower defense game to shoo away the ducks so they don't steal your precious toast. You choose how many flocks of ducks come for your toast each wave, the greater the risk the greater the reward!

    Why similar: Tower Defense 51%, Sandbox 26.7%, Strategy 14.5%, 2D 4.3%, Singleplayer 1.9%

  2. #2 Block Tower TD
    96% matchVery Positive82% of 76 reviews2023
    Dev: MyDreamForever
    Windows
    Median: 2.1 hrsMean: 4.0 hrs≥1hr: 76%

    Block Tower TD is a roguelike tower defense strategy game with interesting innovations. Build a world out of blocks, choose random upgrades to make every run unique.

    Why similar: Tower Defense 36.6%, Sandbox 16.7%, Base Building 15.6%, Strategy 8.4%, Pixel Graphics 8.3%

  3. #3 Mindustry
    96% matchOverwhelmingly Positive96% of 26,625 reviews2019
    Dev: AnukenDev
    Windows · Mac · Linux
    Median: 4.9 hrsMean: 27.5 hrs≥1hr: 76%

    An open-ended factory management game with RTS and tower defense elements.

    Why similar: Tower Defense 36.9%, Base Building 30.7%, Sandbox 10.6%, Building 7.7%, Strategy 7.2%

  4. #4 Yap Wizards Tower Defence
    95% matchVery Positive97% of 146 reviews2025
    Dev: Noffty Productions
    Windows · Mac · Linux

    Dynamic tower defence with an ever-scaling battlefield and unexpected twists!

    Why similar: Tower Defense 48%, Base Building 19.1%, Strategy 15.6%, Pixel Graphics 9.9%, 2D 4.7%

  5. #5 Firework War
    94% matchVery Positive96% of 52 reviews2025
    Dev: 正方形劳伦斯Pub: Gamirror Games
    Windows

    Use a variety of fireworks to fend off misfortune and protect your family!

    Why similar: Tower Defense 66.6%, Strategy 18.6%, Pixel Graphics 8.2%, 2D 3.3%, Indie 2.1%

  6. #6 Relic Guardian - Tower Defense
    92% matchOverwhelmingly Positive95% of 1,000 reviews2025
    Dev: Mystrigger
    Windows
    Median: 2.9 hrsMean: 5.2 hrs≥1hr: 78%

    "Relic Guardian" is a fantasy style strategy tower defense game. As the builder on the battlefield, summon a variety of defense towers and spells with reliable hero companions to complete this epic and guarding adventure!

    Why similar: Tower Defense 49.3%, Pixel Graphics 13.7%, Strategy 11.1%, Building 7.5%, Tactical 6.8%

  7. #7 Planetoid
    94% matchMixed53% of 107 reviews2017
    Dev: GameWriterStudioPub: Conglomerate 5
    Windows
    Median: 3.4 hrsMean: 4.4 hrs≥1hr: 98%

    Planetoid is a physics based building game in which you construct facilities and protect humanoids on the planetoid. Build a facilities which can defeat the enemies on your way.

    Why similar: Tower Defense 39.8%, Sandbox 17.3%, Building 14.7%, Strategy 14.1%, Indie 9.6%

  8. #8 Quacker Bros : First Heist
    93% matchVery Positive94% of 100 reviews2024
    Dev: Reima Project
    Windows

    Quacker Bros is a roguelike TD game about protecting your bounty from the intercepting chicken Mafia! Survive until the help comes and you can finally enjoy the blood and sweat of your heist!

    Why similar: Tower Defense 59.6%, Pixel Graphics 13.6%, Strategy 12.3%, Top-Down 5.7%, 2D 5.7%

  9. #9 Super Sanctum TD
    91% matchVery Positive86% of 1,576 reviews2013
    Dev: Coffee Stain StudiosPub: Coffee Stain Publishing
    Windows · Mac
    Median: 1.9 hrsMean: 33.6 hrs≥1hr: 75%

    Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

    Why similar: Tower Defense 58.9%, Retro 13.3%, Pixel Graphics 9.7%, Strategy 8.2%, 2D 3.6%

  10. #10 Mob Factory
    91% matchMostly Positive73% of 477 reviews2023
    Dev: LiterallyEveryone Games
    Windows
    Median: 1.9 hrsMean: 7.7 hrs≥1hr: 64%

    Mob factory is an tower defense and automation game for the lazy adventurer. Smelt down enemy loot into turrets & factories to automate an ever expanding dungeon from the comfort of your tower.

    Why similar: Tower Defense 38.4%, Base Building 26.4%, Sandbox 12.6%, Building 7.7%, Strategy 6.3%

  11. #11 Oil and Sand
    90% matchVery Positive92% of 117 reviews2024
    Dev: Teamey
    Windows

    An exciting tower defense game where you have to defend your island from the invasion of enemy forces. Your task is to build and upgrade towers to repel waves of attacking enemies.

    Why similar: Tower Defense 90.1%, Indie 6.3%, Singleplayer 3.6%

  12. #12 Cluckmech Oasis
    89% matchVery Positive88% of 3,497 reviews2024
    Dev: BlackLightPub: Mammorize
    Windows · Mac
    Median: 7.0 hrsMean: 15.4 hrs≥1hr: 84%

    Cluckmech Oasis, a top-down shooting Roguelike tower defense game. Play as the Warcluck and lead your team of animal heroes in a fight for survival. Collect, build and upgrade defenses, and engage in intense battle against waves of plant enemies.

    Why similar: Tower Defense 40.5%, Top-Down Shooter 23.5%, Building 11.9%, Pixel Graphics 11.6%, Strategy 9%

  13. #13 Protolife
    89% matchVery Positive86% of 469 reviews2018
    Dev: Volcanic Giraffe
    Windows · Mac
    Median: 3.8 hrsMean: 7.7 hrs≥1hr: 74%

    Protolife is an unique tower-based strategy game which gives you a direct control over the builder robot in a struggle against the hungry proto-life organism.

    Why similar: Tower Defense 39.3%, Base Building 27.7%, Pixel Graphics 11.3%, Strategy 7.9%, Retro 7.2%

  14. #14 TDS - Tower Defense Strategy
    88% matchVery Positive81% of 363 reviews2025
    Dev: Blockage
    Windows · Mac · Linux

    TOWER ▪ DEFENSE ▪ STRATEGY. Control Vessels. Utilize their uniquely deep set of towers. Create an everchanging defense. Play with friends. Protect your Basin at all costs. An absolute Tower Defense, Real-Time Strategy Hybrid

    Why similar: Tower Defense 47%, Base Building 20.4%, Building 13.3%, Pixel Graphics 10.7%, Strategy 4.6%

  15. #15 Broken Universe - Tower Defense
    87% matchVery Positive91% of 312 reviews2023
    Dev: Jinthree Studio
    Windows

    Get ready to rethink all your defense strategies! Build barricades to stop monsters, or lure them into a maze and attack. A variety of stages that change each time depending on how you play them.

    Why similar: Tower Defense 41.2%, Base Building 25.5%, Building 12.8%, Strategy 9%, 2D 4.2%

  16. #16 Infinitode 2 - Infinite Tower Defense
    86% matchVery Positive91% of 4,121 reviews2021
    Dev: Prineside
    Windows · Linux
    Median: 3.2 hrsMean: 45.9 hrs≥1hr: 70%

    Infinitode 2 - a strategy in the Tower Defense genre, in which the player will have to build towers to protect his base from endless waves of enemies. The game features huge maps, lots of towers, resource miners, upgrade tree and map editor.

    Why similar: Tower Defense 50.9%, Building 17.2%, Strategy 10.4%, Tactical 7.5%, Top-Down 5.3%

  17. #17 Mech Fortress
    85% matchVery Positive86% of 243 reviews2026
    Dev: Some Sugar Studio
    Windows

    Mech Fortress is a sci-fi tower defense game where each turret has unique mechanics. You can freely place them on a 5×5 grid, and your goal is to eliminate all enemies!

    Why similar: Tower Defense 73.5%, Strategy 12.8%, Pixel Graphics 7.8%, Top-Down 3.6%, Singleplayer 2.2%

  18. #18 League TD
    86% matchVery Positive87% of 79 reviews2023
    Dev: Wondarabyte
    Windows

    "League Tower Defense" is a strategy tower defense game that combines unique defense towers and various upgradeable components to unleash different attack effects. Come and build your perfect defense line.

    Why similar: Tower Defense 49.5%, Base Building 16.5%, Retro 14.2%, Strategy 10.6%, Tactical 4.5%

  19. #19 Vectorio Classic
    84% matchVery Positive93% of 1,479 reviews2021
    Dev: Ben NicholsPub: BN Games
    Windows · Mac · Linux

    The original, uncompleted version of Vectorio. Claim resources, unlock new buildings, and expand your defenses as you fight back against enemy forces in the classic edition of Vectorio! Play for free now.

    Why similar: Tower Defense 34.9%, Base Building 27.3%, Sandbox 12.7%, Building 9.7%, Strategy 7.1%

  20. #20 Mechs V Kaijus - Tower Defense
    84% matchVery Positive84% of 538 reviews2022
    Dev: Doble Punch Games
    Windows
    Median: 6.8 hrsMean: 13.1 hrs≥1hr: 82%

    Mechs V Kaijus is an addictive hardcore tower defense gameplay. In Mechs V Kaijus you take on the role of Commander of a powerful Mechs squadron. Improve your Mech, strategically place towers and factories on the battlefield. Deploy support units on the battlefield, and save our civilization.

    Why similar: Tower Defense 73.3%, Base Building 7.9%, Strategy 6.9%, Pixel Graphics 6.4%, Indie 2.5%

  21. #21 Defensurvivor
    83% matchMostly Positive72% of 105 reviews2024
    Dev: SignatureGamez
    Windows

    DEFENSURVIVOR is a strategy game where you build obstacles and place and move units to block zombies. There are various units with unique characteristics and powerful high-level units that can be obtained through combination. Use randomly given units to survive until the end!

    Why similar: Tower Defense 45%, Base Building 32.6%, Strategy 8.3%, 2D 4%, Top-Down 3.8%

  22. #22 Towerful Defense: Prologue
    82% matchVery Positive88% of 75 reviews2024
    Dev: Mini Fun Games
    Windows · Mac · Linux

    A tower defense action roguelike where you control a single tower to fight against hordes of aliens coming from all directions. Pick your tower, equip up to 4 skills, and choose from a variety of traits and items to craft powerful builds that lead you to victory.

    Why similar: Tower Defense 69.2%, Strategy 14.9%, 2D 7%, Top-Down 5.4%, Singleplayer 3.6%

  23. #23 The Perfect Tower II
    79% matchVery Positive87% of 4,306 reviews2025
    Dev: Fire Sword Studios
    Windows

    The Perfect Tower II is a mix between an incremental and a tower defense game. Build a town, manage resources and explore a variety of mini-games and tons of upgrades. Fully automate your game and watch numbers going up!

    Why similar: Tower Defense 53.4%, Base Building 34.6%, Strategy 11.2%, Indie 0.5%, Singleplayer 0.3%

  24. #24 Defend Your Life: TD
    82% matchMostly Positive80% of 1,092 reviews2015
    Dev: Alda Games
    Windows · Mac · Linux
    Median: 4.3 hrsMean: 6.4 hrs≥1hr: 96%

    Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy.

    Why similar: Tower Defense 62.3%, Strategy 12.8%, 2D 6.2%, Tactical 5.7%, Top-Down 4.7%

  25. #25 FrankenStorm TD: Prologue
    81% matchVery Positive88% of 355 reviews2021
    Dev: Doodad Games
    Windows

    Roguelite TD: all towers & enemies start the same, but you have 1 choice per wave affecting BOTH and stacking up for dramatic variance. Gradually salvage and make some choices permanent to build deeper strategies. Also a unique mazing challenge where wires and towers must be linked to a power source

    Why similar: Tower Defense 42.7%, Base Building 31%, Building 12.7%, Strategy 7.1%, 2D 3.3%

  26. #26 Project Astra Dominium
    81% matchVery Positive90% of 88 reviews2024
    Dev: Snob Entertainment UG
    Windows · Mac · Linux

    Project Astra Dominium is a Tower Defense game with Basebuilding and Automation elements. Build up your base to become a supply hub for Earth's desperately needed materials, gather resources while defending against an unknown alien threat and improve your tower's and AI capabilities.

    Why similar: Tower Defense 49%, Base Building 35.2%, Strategy 9%, Indie 3.5%, Singleplayer 3.3%

  27. #27 Zombo Buster Advance
    80% matchVery Positive83% of 244 reviews2020
    Dev: FIREBEAST
    Windows · Mac
    Median: 3.1 hrsMean: 9.3 hrs≥1hr: 67%

    Zombo Buster Advance is a tower defense game taking place inside buildings with interchangeable elevators. Deploy, swap and shoot like a boss!

    Why similar: Tower Defense 48.2%, Top-Down Shooter 20%, Strategy 11.2%, Base Building 5.7%, Tactical 4.1%

  28. #28 Stellar Initiative
    78% matchMostly Positive77% of 401 reviews2024
    Dev: Five Head Games
    Windows
    Median: 1.7 hrsMean: 6.5 hrs≥1hr: 65%

    Stellar Initiative is a roguelike tower defense game where you land on the planet and use your orbit ship to deliver buildings and support you with fire. Complete missions, install new upgrades, discover powerful artifacts, and find the best strategy!

    Why similar: Tower Defense 46.8%, Base Building 24.1%, Pixel Graphics 10.9%, Strategy 9%, Building 4.1%

  29. #29 2112TD: Tower Defense Survival
    77% matchVery Positive88% of 435 reviews2023
    Dev: Refinery Games
    Windows

    Get ready for the ULTIMATE tower defense onslaught. Build, deploy, research and upgrade your defenses in this epic, old school RTS inspired sci-fi adventure.

    Why similar: Tower Defense 57.4%, Strategy 11.9%, Retro 8.6%, Tactical 8.1%, Top-Down 5.1%

  30. #30 Antivirus PROTOCOL
    76% matchVery Positive87% of 293 reviews2025
    Dev: FIREHIVE Studio
    Windows

    Antivirus PROTOCOL is an incremental game about destroying viruses. Learn and adapt, collect data, upgrade yourself, and eliminate the Virus that has taken over the world.

    Why similar: Top-Down Shooter 33.1%, Retro 24.4%, Strategy 21%, Pixel Graphics 17.9%, Singleplayer 3.6%

  31. #31 The White Laboratory
    78% matchMostly Positive78% of 362 reviews2019
    Dev: Laboratory Systems
    Windows

    The White Laboratory is a sandbox style physics-based tower defense and RTS game in which you modularly build and command robotic structures. Use them to defend against or conquer other disobedient mechanical blocks on a facility floating in the atmosphere of a remote gas planet.

    Why similar: Tower Defense 55.3%, Strategy 20.7%, Sandbox 16.9%, Indie 7%

  32. #32 Refactor
    77% matchVery Positive84% of 467 reviews2022
    Dev: GAGAPub: LightOn Game
    Windows · Mac
    Median: 1.7 hrsMean: 35.9 hrs≥1hr: 60%

    Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

    Why similar: Tower Defense 44.9%, Building 14.2%, Pixel Graphics 11.1%, Retro 10.2%, Strategy 8.5%

  33. #33 Sand:box
    75% matchVery Positive94% of 1,594 reviews2023
    Dev: smellymoo
    Windows · Mac · Linux
    Median: 1.0 hrsMean: 7.8 hrs≥1hr: 49%

    "Falling sand" style particle sandbox, now with circuits and stickmen!

    Why similar: Sandbox 30.6%, Retro 22.1%, Pixel Graphics 18.5%, Building 14.1%, 2D 6.6%

  34. #34 Defense of Roman Britain
    79% matchMixed61% of 54 reviews2017
    Dev: First Games Interactive
    Windows · Mac

    Tower defense Game to safeguard the land of Rome.

    Why similar: Tower Defense 62.1%, Strategy 14.5%, Sandbox 11.1%, 2D 5.1%, Indie 4.7%

  35. #35 Rogue Tower
    74% matchVery Positive83% of 5,872 reviews2022
    Dev: Die of Death Games
    Windows
    Median: 10.7 hrsMean: 20.3 hrs≥1hr: 91%

    Rogue Tower is a tower defense game with roguelike elements and a continuously expanding path which you can influence. Unlock, build, upgrade, expand, defend.

    Why similar: Tower Defense 63.6%, Base Building 18.2%, Strategy 11%, Building 5.5%, Singleplayer 1.7%

  36. #36 方境战记BlockFight
    75% matchVery Positive82% of 154 reviews2022
    Dev: 喜人一个Pub: Gamirror Games
    Windows

    It's a tower defense game that uses blocks to build fortresses against monsters. Gathering resources, building defenses, and keeping an eye out for the abilities of a variety of monsters.All of these will challenge the player's strategic choices, resource management, and immediate reactions.

    Why similar: Tower Defense 48.6%, Base Building 32.2%, Strategy 9.9%, 2D 3.8%, Tactical 3%

  37. #37 Tower Ball - Incremental Tower Defense
    76% matchMixed62% of 234 reviews2021
    Dev: WaffleStack Studio LLC
    Windows

    Build turrets to destroy balls & earn cash, spend it to upgrade and get stronger

    Why similar: Tower Defense 61.3%, Building 15.2%, Strategy 12.2%, 2D 5.5%, Singleplayer 3.3%

  38. #38 Tangy TD
    71% matchVery Positive92% of 1,348 reviews2026
    Dev: Cakez
    Windows
    Median: 1.4 hrsMean: 3.6 hrs≥1hr: 56%

    Strategic tower defense where you play a witch, place class-based towers, equip them with items that grant powerful abilities, combine them, create unique builds & deal ridiculous amounts of damage! Customize your builds with a deep stat system and giant skill tree!

    Why similar: Tower Defense 60.3%, Strategy 11.7%, Pixel Graphics 10.3%, Tactical 7%, 2D 4.9%

  39. #39 Dr. Professor Scientist's Weapons Testing Facility
    74% matchVery Positive84% of 77 reviews2022
    Dev: Cool Smithy Games
    Windows

    DPSWTF is a base defense game with roguelike elements, where instead of placing towers, you build the best tower of them all. Combine the best projectiles with effective modifiers and push back the incoming hordes. Research them all to conquer the secrets of the Great North!

    Why similar: Tower Defense 62.8%, Building 16.2%, Strategy 10.9%, 2D 5.5%, Top-Down 4.7%

  40. #40 Welcome To Your Immune System
    73% matchVery Positive92% of 52 reviews2021
    Dev: The VALIDATE Network
    Windows · Mac

    Welcome to Your Immune System is an addictive retro arcade-style video game where you defend human cells from invading bacteria. Use all the weapons in your arsenal from macrophages, killer T cells, to cytokines and learn how these work in real life.

    Why similar: Top-Down Shooter 45.4%, Retro 32.7%, 2D 10.3%, Singleplayer 7.7%, Adventure 3.9%

  41. #41 Zombie Defense
    72% matchVery Positive84% of 2,168 reviews2016
    Dev: Home Net Games
    Windows · Mac · Linux
    Median: 1.6 hrsMean: 6.7 hrs≥1hr: 58%

    A modern hybrid of the classic RTS and modern Tower Defense. Recruit soldiers, place them on slots and let them shoot incoming waves of zombies by their own. Order supplies, throw grenades, order airstrikes and many more... Perfect mix of strategy, tactics and micromanagement.

    Why similar: Tower Defense 80.7%, Strategy 12.7%, Singleplayer 2.7%, Indie 2.5%, Top-Down 1.5%

  42. #42 Fire at Campsite
    70% matchVery Positive82% of 57 reviews2025
    Dev: Salvador PalmaPub: ZOO Studios
    Windows · Mac · Linux

    Protect the campsite in this Single-Tower-Defense game where you play as a campfire against the local wildlife! With many abilities and characters at your disposal, try new builds, synergies, and combos to make those animals run away with fear!

    Why similar: Tower Defense 59.4%, Strategy 14%, Tactical 9.2%, Top-Down 6.6%, 2D 6.6%

  43. #43 1BIT CASTLE
    73% matchMostly Positive75% of 104 reviews2019
    Dev: kantal collective
    Windows

    1BIT CASTLE is a little tower defense game in which we are defending castle from the monsters.

    Why similar: Tower Defense 62.8%, Retro 22.2%, Indie 9%, 2D 6%

  44. #44 Final War: Frozen Defense
    71% matchMixed46% of 105 reviews2025
    Dev: HaoPlay Limited
    Windows

    Strategy Tower Defense, RTS Battles on the World Map

    Why similar: Tower Defense 66.9%, Strategy 16.4%, Tactical 5.6%, Building 5.3%, Top-Down 5.1%

  45. #45 Clean'Em Up
    73% matchVery Positive90% of 73 reviews2016
    Dev: Cheesy Holes
    Windows

    Clean’Em Up is a fast paced, arcade-style Top Down Shooter with neon graphics. You play as an Upgradable Antivirus. You seek and destroy tremendous viruses and threats, collect and protect files and survive huge Bosses. The story is simple: Your Computer has been hacked... Dozens of viruses and other threats have penetrated your System...

    Why similar: Indie 100%

  46. #46 Sunstone War
    69% matchVery Positive98% of 54 reviews2024
    Dev: Blukulélé
    Windows · Mac · Linux

    Sunstone War is a unique Action game with Tower Defense element where you can carry EVERYTHING! Move towers, toss away enemies, carry obstacles, upgrade skills and journey through lands to protect your village from calamity!

    Why similar: Tower Defense 51.4%, Pixel Graphics 14.3%, Strategy 10.8%, Tactical 6.8%, Top-Down 4.6%

  47. #47 Ultimate Protector
    70% matchVery Positive89% of 63 reviews2022
    Dev: Dongguan Liuli Game Technology Co.,Ltd
    Windows

    Tired of moving around without purposes? Come and protect the goddess with multiple combination of skills and elements. Discover and upgrade your weapon to super, even hyper! Play this game with a joy from both tower defense and rogue!

    Why similar: Tower Defense 64.5%, Pixel Graphics 12.9%, Strategy 7.1%, Tactical 6.3%, 2D 5.1%

  48. #48 Orcdom
    68% matchVery Positive90% of 71 reviews2025
    Dev: GAGAPub: OKJOY
    Windows

    Orcdom is a minimalist tower defense game with full freedom in tower placement. Defend your crystal from waves of orcs attacking from all directions. Plan your layout, time your spells, and unlock new strategy modes in this fast-paced tactical challenge!

    Why similar: Tower Defense 39.7%, Base Building 22.2%, Pixel Graphics 10.2%, Building 9.5%, Strategy 8.1%

  49. #49 Cyber Tower 2048
    68% matchVery Positive87% of 101 reviews2025
    Dev: Galactic Geckon
    Windows

    Cyber Tower 2048 is an action tower defense game where players fight insectoids by building defenses and developing tactics.

    Why similar: Tower Defense 65.4%, Retro 9.1%, Pixel Graphics 7.9%, Strategy 5%, 2D 3.9%

  50. #50 McDROID
    72% matchMostly Positive73% of 215 reviews2014
    Dev: Elefantopia
    Windows
    Median: 3.3 hrsMean: 4.3 hrs≥1hr: 93%

    Farm, Build, Defend, in the Galaxy's only Arcade-Tower-Defense.

    Why similar: Tower Defense 49.1%, Base Building 35.8%, Strategy 9.2%, Indie 2.7%, Singleplayer 1.9%

  51. #51 Tower Factory
    67% matchVery Positive89% of 1,199 reviews2024
    Dev: Gius Caminiti
    Windows
    Median: 2.6 hrsMean: 6.5 hrs≥1hr: 74%

    Tower Factory is a tower defense and automation game with roguelite elements. Optimize resource production using conveyor systems while defending against monster waves. Can you find and destroy the enemy tower before it's too late?

    Why similar: Tower Defense 41%, Base Building 28.7%, Sandbox 10.8%, Building 9.3%, Strategy 8.3%

  52. #52 PolyCore Defense
    69% matchVery Positive90% of 58 reviews2022
    Dev: TorksGame
    Windows

    PolyCore Defense is a tower defense game where you have to raise your defenses in order to defend your core. Build unique turrets, upgrade them with special effects and use abilities to survive waves of enemies that are trying to destroy your core!

    Why similar: Tower Defense 62.6%, Strategy 12.4%, Building 9%, Top-Down 4.8%, Tactical 4.4%

  53. #53 Bees vs Zombees
    67% matchVery Positive89% of 104 reviews2024
    Dev: DeadpixelPub: Nuntius Games
    Windows

    A fast-paced roguelike tower defense where you choose your Queen Bee with unique skills and the Artisan to build turrets and cast powerful spells to defend your hive through regions infested with zombees. Face bosses with insane mechanics and survive the Zumbeecalypse!

    Why similar: Tower Defense 64.5%, Pixel Graphics 13.7%, Strategy 13.7%, Singleplayer 4.8%, Indie 3.3%

  54. #54 Firebase Defence
    71% matchMostly Positive75% of 61 reviews2019
    Dev: Rasmus Agergaard
    Windows

    Firebase Defence is a new spin on the traditional tower defence gameplay. You have to defend yourself from the waves upon waves of incoming enemies. You are free to build, place and manage your available resources and units in any way you want. But failing to balance those will result in defeat!

    Why similar: Tower Defense 43.1%, Base Building 24.6%, Strategy 12.4%, Building 6.2%, Indie 4%

  55. #55 Operation Octo
    66% matchVery Positive99% of 107 reviews2025
    Dev: Klub Kofta Studio
    Windows · Mac · Linux

    Play as an Octopus scientist fighting off sunken skeletons in this frantic aquatic Tower Defense! Discover sea life turrets from unique biomes: Pistol Shrimp! Navy Seal! Death Ray! Deploy turrets whilst dodging enemy bullets as you venture the seven seas!

    Why similar: Tower Defense 52.6%, Base Building 22%, Strategy 10.7%, Tactical 4.3%, Singleplayer 3%

  56. #56 Outpost
    68% matchVery Positive87% of 790 reviews2020
    Dev: Open Mid Interactive
    Windows · Mac · Linux
    Median: 1.0 hrsMean: 5.4 hrs≥1hr: 50%

    Outpost brings the perfect mix between survival and roguelite gameplay. Start the game in a randomly generated environment and try to adapt, and make it through as many nights as possible. How long can you survive?

    Why similar: Tower Defense 37.6%, Base Building 22.1%, Sandbox 11.6%, Building 10.4%, Strategy 8.2%

  57. #57 Shakedown: Hawaii
    67% matchVery Positive90% of 653 reviews2020
    Dev: Vblank Entertainment, Inc.
    Windows
    Median: 2.8 hrsMean: 4.8 hrs≥1hr: 78%

    Build a "legitimate" corporation via open world missions, shakedowns, sabotage and property acquisition.

    Why similar: Top-Down Shooter 28.5%, Sandbox 21.1%, Building 14.6%, Retro 12.1%, Pixel Graphics 12%

  58. #58 They Are Coming
    65% matchVery Positive90% of 564 reviews2023
    Dev: OnHit Developments
    Windows

    They Are Coming is a hybrid game that combines roguelike, tower defense, and base building in a side-scrolling shooter format. It offers a straightforward gaming experience for pure enjoyment.

    Why similar: Tower Defense 38.7%, Base Building 25.1%, Sandbox 11.4%, Pixel Graphics 8.2%, Strategy 7.7%

  59. #59 Abort, Retry, Fail
    67% matchVery Positive89% of 83 reviews2022
    Dev: Manpukuken Ramen
    Windows

    Abort, Retry, Fail is a top-down roguelike action adventure in which you play as a lazy programmer that has to generate his own weapon and shoot his way through hordes of enemies. Are you brave enough to help him escape from computer hell of Windows 98?

    Why similar: Pixel Graphics 37.1%, 2D 21.4%, Top-Down 20.4%, Indie 7.3%, Adventure 6.9%

  60. #60 MyTD 我的塔防
    70% matchMixed57% of 68 reviews2017
    Dev: DaTigerGame
    Windows

    [MYTD] is a tower defense strategy game, Unlike traditional tower defense.[MYTD] has added a lot of fresh play.[MYTD] is a pixel tower game strategy placed through games, with endless defense mode, character upgrades, defensive towers skills to choose, turret and changeful, one thousand kinds of style let you challenge without limit, the...

    Why similar: Tower Defense 66.5%, Strategy 25.2%, Indie 8.4%

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