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Games Like Welcome To Your Immune System

60+ similar titles based on shared tags and player behavior. Themes include Action, Singleplayer, Indie, Arcade.

Welcome To Your Immune System header art

Welcome to Your Immune System is an addictive retro arcade-style video game where you defend human cells from invading bacteria. Use all the weapons in your arsenal from macrophages, killer T cells, to cytokines and learn how these work in real life.

Reviews: Very Positive — 94% — of 52 reviews
Released: 2021-12-09
Developer: The VALIDATE Network
Genres: Action, Casual, Free To Play
Platforms: Windows, Mac

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  1. #1 Life on the Edge
    97% matchVery Positive91% of 95 reviews2022
    Dev: LOTE Team
    Windows · Mac

    Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!

    Why similar: Medical Sim 37%, Science 30.5%, Education 21.7%, Action 4.9%, Colorful 3.4%

  2. #2 Defend Your Life: TD
    96% matchMostly Positive80% of 1,092 reviews2015
    Dev: Alda Games
    Windows · Mac · Linux
    Median: 4.3 hrsMean: 6.4 hrs≥1hr: 96%

    Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy.

    Why similar: Education 49.1%, Cute 13.2%, Colorful 12.7%, Casual 10.8%, 2D 9.6%

  3. #3 Vital Signs: Emergency Department
    96% matchMixed56% of 73 reviews2020
    Dev: BreakAway Games
    Windows · Mac

    Play a doctor in Vital Signs: Emergency Department and challenge your medical knowledge to help treat a wide array of cases who come into the ER.

    Why similar: Medical Sim 65.9%, Education 24.5%, Colorful 4.8%, 2D 3.1%, Singleplayer 1.8%

  4. #4 Germ Wars
    95% matchMixed56% of 249 reviews2016
    Dev: Svarog StudiosPub: Back To Basics Gaming
    Windows
    Median: 3.1 hrsMean: 3.7 hrs≥1hr: 90%

    Take control of a determined White Blood Cell on a quest for self discovery, vengeance, punishment and annihilation of all evil germs who would dare infiltrate an unsuspecting and innocent human body in this unique and organic experience.

    Why similar: Action 52.8%, Arcade 26.1%, Casual 21.2%

  5. #5 Antivirus PROTOCOL
    93% matchVery Positive87% of 287 reviews2025
    Dev: FIREHIVE Studio
    Windows

    Antivirus PROTOCOL is an incremental game about destroying viruses. Learn and adapt, collect data, upgrade yourself, and eliminate the Virus that has taken over the world.

    Why similar: Arcade 16.7%, Top-Down Shooter 15%, Shooter 13.8%, Colorful 12.9%, Retro 11.6%

  6. #6 Clean'Em Up
    94% matchVery Positive90% of 72 reviews2016
    Dev: Cheesy Holes
    Windows

    Clean’Em Up is a fast paced, arcade-style Top Down Shooter with neon graphics. You play as an Upgradable Antivirus. You seek and destroy tremendous viruses and threats, collect and protect files and survive huge Bosses. The story is simple: Your Computer has been hacked... Dozens of viruses and other threats have penetrated your System...

    Why similar: Action 100%

  7. #7 Virus Popper
    94% matchVery Positive86% of 64 reviews2020
    Dev: Alexander ClarkPub: Starcade Arcade
    Windows

    Greetings Space Traveler, we need you to save the universe again! New virus variants threaten our galaxy. Level up with a new arsenal of weapons to combat them!

    Why similar: Education 56.2%, Arcade 25.6%, Casual 8.3%, Action 6.9%, Singleplayer 3.1%

  8. #8 Pewt 'em Up!
    92% matchVery Positive96% of 171 reviews2022
    Dev: team tsoto
    Windows · Linux

    Pewt 'em Up! is a retro inspired arcade space shoot 'em up with lots of upgrades, achievements, extras and more.

    Why similar: Shoot 'Em Up 29.5%, Arcade 19.5%, Shooter 17.5%, Space 10.5%, Retro 9.1%

  9. #9 Chicken Invaders 1
    91% matchVery Positive92% of 61 reviews2025
    Dev: InterAction studios
    Windows

    Save Earth from an invasion of intergalactic chickens! Finger-blistering arcade shooting action for one or two players.

    Why similar: Shoot 'Em Up 21.9%, Arcade 15.7%, Shooter 13.2%, Top-Down Shooter 12.6%, Action 8.9%

  10. #10 Pamina VS Slimes
    90% matchVery Positive97% of 72 reviews2024
    Dev: Rune Game Dev
    Windows

    Pamina VS Slimes is a fast-paced top-down arcade game where you defend your home from endless waves of slimes. Choose from 4 headpattable characters, master elemental strategies, and unleash powerful burst skills across 4 game modes. Get ready for non-stop action!

    Why similar: Shoot 'Em Up 30%, Arcade 19.5%, Shooter 13%, Colorful 9.9%, Cute 7.8%

  11. #11 Kellogg's Gut Bacteria Reef
    91% matchPositive84% of 50 reviews2021
    Dev: NAKATOMIPub: KELLOGG
    Windows

    Explore the human gut like never before!

    Why similar: Medical Sim 63.5%, Education 31.2%, Adventure 4.1%, Singleplayer 1.3%

  12. #12 Chicken Invaders Universe
    89% matchVery Positive91% of 3,731 reviews2022
    Dev: InterAction studios
    Windows
    Median: 54 minMean: 12.6 hrs≥1hr: 47%

    A deliciously addictive core of finger-blistering shooting action, surrounded by delectable morsels of galactic exploration, spacecraft customization, and community competitions.

    Why similar: Shoot 'Em Up 22.3%, Top-Down Shooter 16.1%, Shooter 13%, Space 12.7%, Arcade 11.9%

  13. #13 Inside Me
    89% matchVery Positive80% of 50 reviews2015
    Dev: SnowBiteGames
    Windows
    Median: 4.2 hrsMean: 5.4 hrs≥1hr: 95%

    "Inside Me" is a top-down shooter in which you play as one of nanorobots embedded in the human body to fight infection.

    Why similar: Action 100%

  14. #14 I, Toaster
    87% matchVery Positive86% of 57 reviews2023
    Dev: HotCroutons
    Windows · Mac

    Defend your city from the appliance uprising! Play as a Rebellious Hero who is a neural networks backup file loaded into the toaster. Guns! Toaster!

    Why similar: Arcade 36.8%, Shooter 32%, Colorful 15.4%, Action 15%, Singleplayer 0.9%

  15. #15 Laser Disco Defenders
    88% matchVery Positive83% of 52 reviews2016
    Dev: Out Of BoundsPub: Excalibur Publishing
    Windows · Mac
    Median: 3.0 hrsMean: 3.7 hrs≥1hr: 93%

    A self-inflicted bullet hell that combines retro sci-fi with the sounds and sights of the disco era

    Why similar: Shoot 'Em Up 30.6%, Top-Down Shooter 14.1%, Arcade 13.6%, Shooter 13.4%, Action 8.6%

  16. #16 Plasma Puncher
    86% matchVery Positive87% of 78 reviews2017
    Dev: TomatotrapPub: Dragon Lord Studio
    Windows
    Median: 3.1 hrsMean: 3.7 hrs≥1hr: 88%

    Plasma Puncher is an action-brawler taking place at a cellular level! As the last standing white blood cell, you must destroy the virulent army of microbes that invaded the bloodstream, using your bare fists and an assortment of power-ups and special attacks! It's all about punching amoebas into oblivion, baby!

    Why similar: Arcade 35.5%, Cute 15.5%, Action 14.2%, Casual 13.2%, 2D 10.7%

  17. #17 Its Simple, SHOOT
    86% matchVery Positive93% of 69 reviews2019
    Dev: KyleR
    Windows

    Its Simple, SHOOT! Is a minimalist top down 2D waveshooter that has the player utilizing various weapons and abilities to overcome their foes.

    Why similar: Action 52.6%, Casual 47.4%

  18. #18 Arcade Mayhem Juanito
    85% matchVery Positive94% of 362 reviews2017
    Dev: Game Ever Studio
    Windows
    Median: 3.8 hrsMean: 4.4 hrs≥1hr: 94%

    Arcade Mayhem Juanito is a retro experience about arcade-hopping. Teleport into different video games, play with unique mechanics inspired by well-known arcade games, face stunningly animated bosses and join the fight against the clonocell invasion.

    Why similar: Shoot 'Em Up 26.7%, Arcade 21%, Retro 13.3%, Action 13.3%, Casual 12.5%

  19. #19 Space Wars
    84% matchVery Positive83% of 122 reviews2020
    Dev: High and WidePub: khukhrovr
    Windows

    Defend Earth's orbital station from alien invaders in SPACE WARS, a fast-paced arcade shooter. Customize your ship, upgrade weapons, and battle through intense levels to save humanity in this action-packed space adventure.

    Why similar: Space 28.5%, Arcade 27.2%, Shooter 23%, Casual 8.9%, 2D 8.9%

  20. #20 Darwin's Demons
    84% matchVery Positive90% of 50 reviews2017
    Dev: Polymorphic Games
    Windows · Mac · Linux

    Darwin’s Demons is an arcade style space shooter in which you battle a population of evolving aliens. The alien’s morphology, fire type, and behaviors are all encoded by a digital genome. The aliens that are best able to shoot or evade you reproduce to make the next generation.

    Why similar: Action 54.6%, Casual 45.4%

  21. #21 CPU Invaders
    83% matchVery Positive83% of 766 reviews2017
    Dev: Microblast GamesPub: SA Industry
    Windows
    Median: 3.0 hrsMean: 20.3 hrs≥1hr: 86%

    Invaders are living inside your computer. You shouldn't let that happen! Interact with your desktop while playing, watch Youtube videos, chat with your friends and more! CPU Invaders overlaps the game itself with your computer screen.

    Why similar: Shoot 'Em Up 35%, Arcade 22.8%, Casual 12.3%, Colorful 7.3%, Action 7.1%

  22. #22 Albert and Camille's Little Lille Adventure
    82% matchVery Positive90% of 71 reviews2021
    Dev: The VALIDATE Network
    Windows · Mac

    Explore a war-torn city, avoid capture by soldiers, and collect the supplies Albert and Camille need to create the first vaccine to fight tuberculosis. As you progress, you will learn about the methods used to create BCG and how vaccines work.

    Why similar: Education 49%, Science 30.3%, Cute 10.9%, 2D 6.4%, Adventure 1.8%

  23. #23 METAL BEANS
    81% matchVery Positive92% of 53 reviews2024
    Dev: artsy_viiPub: TEAM LOADING PIXELS
    Windows

    METAL BEANS is a 3D Action-Arcade game where you control two desktop buddies in a computer space. Protect the PC from digital threats by charging up your way through virus creatures and upgrading Catbot and Robitz in the system!

    Why similar: Arcade 41.5%, Action 23.1%, Retro 19%, Casual 14.3%, Singleplayer 2.1%

  24. #24 Retrograde Arena
    79% matchVery Positive94% of 531 reviews2020
    Dev: FreemergencyPub: Neon Doctrine
    Windows
    Median: 30 minMean: 5.2 hrs≥1hr: 40%

    Retrograde Arena is a multiplayer twin stick shooter where bullets don’t kill. Use weapons, physics, and your Drone to push, pull, and blast your foes into deadly surroundings in this skill-based shooter action title that redefines physics-based action.

    Why similar: Vehicular Combat 28.6%, Shoot 'Em Up 21.2%, Top-Down Shooter 15.2%, Arcade 12.6%, Shooter 11.6%

  25. #25 Offendron Warrior
    81% matchPositive86% of 50 reviews2018
    Dev: Hijong ParkPub: PsychoFlux Entertainment
    Windows

    Offendron Warrior is a retro arcade that combines shooting and defense. Your objective is saving Offendron civilians in the planets from the group of enemies, who are trying to spread a virus that turns Offendrons into mindless killing machines and eventually destroy the whole planet.

    Why similar: Shoot 'Em Up 29.9%, Arcade 16.6%, Shooter 16%, Space 14.6%, Retro 10.3%

  26. #26 Genome Guardian
    77% matchVery Positive92% of 770 reviews2024
    Dev: Alpherior
    Windows
    Median: 3.8 hrsMean: 5.8 hrs≥1hr: 83%

    COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

    Why similar: Science 39.6%, Top-Down Shooter 19.6%, Shooter 17.6%, Colorful 8.3%, Cute 6.8%

  27. #27 Grav Blazer Squared
    82% matchMixed40% of 85 reviews2017
    Dev: Ripknot Systems
    Windows
    Median: 0 minMean: 2.5 hrs≥1hr: 11%

    Grav Blazer is an arcade space shooter with a focus on fast paced action. Skill based firing mechanics, rotational controlled power attacks, increasing level difficulty, and endless procedurally generated levels are some of the features players will experience.

    Why similar: Shoot 'Em Up 25.5%, Arcade 15.1%, Shooter 14.3%, Space 11%, Retro 7.4%

  28. #28 Burning Skies Arcade
    78% matchVery Positive84% of 56 reviews2024
    Dev: NukGames
    Windows

    Lt Blitz has the city sieged, and it's your job to destroy his troops. Shoot, dodge and upgrade your jet and and try to take on this challenge! Burning Skies is a free, endless retro shmup, that will take you right back to the era of arcade machines, with modernized graphics and gameplay!

    Why similar: Shoot 'Em Up 30.3%, Top-Down Shooter 20.8%, Shooter 18.3%, Retro 9.7%, Action 7.9%

  29. #29 Super Space Club
    78% matchVery Positive82% of 50 reviews2023
    Dev: GrahamOfLegend
    Windows

    Super Space Club is a lo-fi arcade space shooter to chill to. Defend a vibrant galaxy as a club of misfit heroes and battle endless waves of spacecrafts to the tune of atmospheric beats. Outlast your enemies and vibe to the rhythm of the stars.

    Why similar: Vehicular Combat 22.1%, Shoot 'Em Up 19.9%, Arcade 13.3%, Top-Down Shooter 12.9%, Space 11.9%

  30. #30 Infectious
    79% matchMixed65% of 80 reviews2020
    Dev: Ziggy Makes Games
    Windows

    Play as a lethal virus infecting various organs in your host's body while trying to outsmart the immune cells that seek to eliminate you and your kind. Generate clones and watch them propagate, infecting cells and taking down bosses.

    Why similar: Science 64.1%, Arcade 19.9%, Action 6.2%, Casual 6.1%, 2D 2.7%

  31. #31 Stellar 2D
    80% matchMixed41% of 975 reviews2015
    Dev: quad gamesPub: Back To Basics Gaming
    Windows
    Median: 3.0 hrsMean: 4.6 hrs≥1hr: 92%

    Stellar 2D is a retro style space arcade game, it's a 2D game in a 3D world. With an addictive, fast paced, casual game-play style.

    Why similar: Shoot 'Em Up 43.7%, Action 23.6%, Casual 23.5%, 2D 9.3%

  32. #32 Cozy Space Survivors
    74% matchVery Positive97% of 364 reviews2024
    Dev: simonschreibt
    Windows · Mac · Linux

    A cozy time survival roguelite in space. You steer the shippy while the shooting happens automatically. Meet cute NPCs, solve small quests, and fight quirky enemies with satisfying weapons. A shorter experience for people who don't have much time but love playing (and finishing) games.

    Why similar: Top-Down Shooter 25.9%, Arcade 21.1%, Space 12.9%, Cute 12.4%, Colorful 9.1%

  33. #33 Razerwire:Nanowars
    76% matchVery Positive86% of 109 reviews2018
    Dev: Hammer & Ravens
    Windows
    Median: 12 minMean: 1.8 hrs≥1hr: 32%

    A modern revisitation of the 80s arcades. Use your Razerwire to cut through waves of nanobugs with a rogue-like inspired progression.

    Why similar: Shoot 'Em Up 31%, Arcade 18%, Shooter 17.1%, Space 11.3%, Colorful 7.7%

  34. #34 Cyberhunt
    74% matchVery Positive85% of 2,639 reviews2017
    Dev: NukGames
    Windows
    Median: 3.7 hrsMean: 7.0 hrs≥1hr: 89%

    Cyberhunt is a retro procedurally generated twin stick shooter, that takes you back to the sweet to the sweet arcade machines era!

    Why similar: Shoot 'Em Up 24.6%, Top-Down Shooter 15.7%, Arcade 14.9%, Space 13.9%, Retro 10.6%

  35. #35 PooShooter: Toilet Invaders
    77% matchMostly Positive74% of 100 reviews2016
    Dev: FergaTroid Studios
    Windows

    Pooshooter: Toilet Invaders is a 2D action comedy game packed with explosions and fun gameplay. Reminiscent of arcade classics like Space Invaders, PooShooter lets you take control of a Bum fighting against vengeful Toilets.

    Why similar: Action 100%

  36. #36 Vaccine19
    76% matchMostly Positive75% of 77 reviews2020
    Dev: coolnames
    Windows

    100% Free 'Hip-Fire' Arcade Shooter! Instead of using crosshairs or sights on gun, Vaccine19 has the player visualize shot trajectory. Don't Get Infected!

    Why similar: Shooter 47.1%, Action 19.5%, Casual 16.6%, Space 15.2%, Singleplayer 1.5%

  37. #37 Rhythm Doctor
    66% matchOverwhelmingly Positive98% of 25,916 reviews2025
    Dev: 7th Beat Games
    Windows · Mac · Linux
    Median: 3.5 hrsMean: 8.8 hrs≥1hr: 78%

    Save patients with your rhythm mastery! Rhythm Doctor is a rhythm game where you heal patients by defibrillating in time to their heartbeats. Learn each patient's unique heartbeat and defeat boss viruses trying to sabotage your rhythm, all set to heart-pumping, soul-soothing music.

    Why similar: Arcade 32.5%, Cute 19.2%, Colorful 17.3%, Action 13.4%, 2D 11.4%

  38. #38 Itty Bitty Toilet Kitty
    72% matchVery Positive86% of 63 reviews2025
    Dev: Shent GamesPub: Shent Games
    Windows

    BE A CAT! SAVE YOUR HUMAN! You're a fluffy feline who must save their owner from the hordes of flesh eating greebles which dwell within the bathroom. Will she make it through her morning business alive? Only you can save her!

    Why similar: Arcade 29.5%, Retro 19.3%, Cute 19%, Casual 11%, 2D 9.9%

  39. #39 Boss 101
    75% matchVery Positive83% of 77 reviews2017
    Dev: Donley Time Foundation
    Windows
    Median: 4.7 hrsMean: 5.6 hrs≥1hr: 94%

    Create your own bosses to battle in this arcade action and adventure. Yep, there is a story as well as pure action modes for those who want to blast things. Explore worlds while you upgrade your tech and improve your base. Make new friends, adopt pets and even fly a kite.

    Why similar: Shoot 'Em Up 37.6%, Arcade 17.4%, Action 12.3%, Retro 11.1%, Cute 8.9%

  40. #40 Galactic Bulwark Strike
    73% matchVery Positive96% of 50 reviews2018
    Dev: Josep G. Camarasa
    Windows

    An addictive physics-based mix of a shoot'em up and arkanoid. Defeat all the enemies while you keep the ball alive in this frantic retro-styled arcade game.

    Why similar: Action 51.1%, Casual 48.9%

  41. #41 Grav Blazer
    75% matchMixed48% of 157 reviews2017
    Dev: Ripknot Systems
    Windows
    Median: 0 minMean: 2.9 hrs≥1hr: 12%

    Grav Blazer is an arcade space shooter with a focus on fast paced action. Skill based firing mechanics, rotational controlled power attacks, increasing level difficulty, and endless procedurally generated levels are some of the features players will experience.

    Why similar: Shoot 'Em Up 21.3%, Top-Down Shooter 14.6%, Arcade 14.1%, Shooter 12.6%, Space 11.7%

  42. #42 ImageStriker
    72% matchVery Positive93% of 91 reviews2019
    Dev: TERARIN GAMES
    Windows

    Image Striker is a 2D vertical scroll shooting game.

    Why similar: Shoot 'Em Up 38.1%, Shooter 20.4%, Retro 12.8%, Arcade 11.4%, Action 6.2%

  43. #43 Droid Assault
    73% matchVery Positive83% of 374 reviews2013
    Dev: Puppygames
    Windows · Mac · Linux
    Median: 1.7 hrsMean: 3.9 hrs≥1hr: 90%

    Play Droid Assault and experience running blaster battles with hordes of rampaging killer robots! Discover a unique tactical arcade shooter, with the fun addictive gameplay of 8-bit classics. You'll need your wits and the help of your acquired droid squad to stay alive in this fast-paced retro actionfest.

    Why similar: Arcade 27.9%, Shooter 18.9%, Action 17.5%, Top-Down Shooter 17.5%, Retro 15.2%

  44. #44 InCell VR
    73% matchMixed69% of 287 reviews2015
    Dev: Luden.io
    Windows · Mac · Linux
    Median: 42 minMean: 13.0 hrs≥1hr: 42%

    InCell is an action/racing VR game with a bit of strategy and science thrown into the mix. You'll take an exciting journey inside the highly unusual micro world of human cell and stop the virus advance. The game is focused on VR but you can play just fine without a set.

    Why similar: Science 60%, Education 32.3%, Action 4.7%, Singleplayer 2.9%

  45. #45 Grab and Guts
    69% matchVery Positive94% of 93 reviews2024
    Dev: Galactic Geckon
    Windows

    Grab and Guts - Shooter about JuraPis' journey through the human body, microscopic world, and unimaginable liquids and corners of light. Use your grappling hook to navigate, gather weapons, and eliminate parasitic enemies.

    Why similar: Shoot 'Em Up 42.8%, Shooter 20.6%, Arcade 10.1%, Casual 9.9%, 2D 6.4%

  46. #46 FreeInfantry
    70% matchVery Positive83% of 160 reviews2024
    Dev: FreeInfantry Group
    Windows

    Isometric. Massively Multiplayer. Capture The Flag. Skirmish. Bug Hunt. And more. Welcome to FreeInfantry - the world's first massive multiplayer online isometric shooter.

    Why similar: Top-Down Shooter 25.7%, Arcade 22.8%, Shooter 20.9%, Space 15.5%, Action 8.6%

  47. #47 HoloCure - Save the Fans!
    64% matchOverwhelmingly Positive99% of 39,748 reviews2023
    Dev: KayAnimate
    Windows

    Play as your favorite Vtubers from Hololive! Fight, explore, and clear your way through armies of fans and save them from their mind-control in this unofficial free fan-game.

    Why similar: Top-Down Shooter 25.8%, Arcade 19.1%, Cute 17%, Colorful 11.2%, Action 8.1%

  48. #48 Outnumbered
    70% matchMostly Positive79% of 241 reviews2022
    Dev: Amped Horizon
    Windows

    Outnumbered is a mass-enemy top-down shooter with rogue-lite elements. You may be greatly outnumbered, but not outpowered. Evolve into the ultimate weapon of destruction!

    Why similar: Shoot 'Em Up 28.1%, Top-Down Shooter 18.9%, Arcade 14.7%, Shooter 14.2%, Action 7.4%

  49. #49 The Body VR: Journey Inside a Cell
    70% matchVery Positive92% of 271 reviews2016
    Dev: The Body VR LLC
    Windows
    Median: 18 minMean: 7.6 hrs≥1hr: 29%

    The Body VR: Journey Inside a Cell is an educational virtual reality experience that takes the user inside the human body.

    Why similar: Education 78%, Casual 22%

  50. #50 Incandescent
    71% matchMixed68% of 172 reviews2015
    Dev: Stephen Crabb
    Windows
    Median: 3.0 hrsMean: 3.5 hrs≥1hr: 82%

    Incandescent is a fast paced action arcade game that scales the difficulty to your skill level. The goal is simple, pilot your ship and defend yourself against waves of unique enemies and bosses. Different powerups will drop to help you with upgrades to your weapons and health.

    Why similar: Shoot 'Em Up 47.9%, Arcade 20.4%, Action 19.4%, 2D 6.4%, Casual 5.9%

  51. #51 Corn Defenders
    68% matchVery Positive92% of 60 reviews2022
    Dev: Jackson WynnPub: JC384
    Windows

    A modern game inspired by many popular 1980s arcade games that depicts a student locked inside of a school. You will need to trade for and collect corn to escape. You will also need to run away from Dr. Small and the teachers

    Why similar: Arcade 35.1%, Action 22.6%, Retro 14.8%, 2D 10.1%, Adventure 9.2%

  52. #52 SUPER CIRCUIT BREAKERS
    69% matchVery Positive82% of 94 reviews2020
    Dev: Triverske
    Windows

    Back with new weapons, new enemies, and with more circuits to break than ever! Destroy millions of robots in this free-to-play shooter with up to 6 players.

    Why similar: Top-Down Shooter 19.9%, Arcade 15.7%, Shooter 14.8%, Space 13%, Cute 9.6%

  53. #53 Polygoneer
    68% matchMostly Positive79% of 1,730 reviews2017
    Dev: NukGames
    Windows
    Median: 48 minMean: 18.2 hrs≥1hr: 46%

    Test your reflexes in POLYGONEER, defend yourself from prolygonal shapes taht comes from everywhere, just hitting is not enough you need to match the right color shot to the polygon too! Are you ready for the challenge?

    Why similar: Shoot 'Em Up 24.1%, Arcade 18%, Top-Down Shooter 13.2%, Casual 9.6%, Action 9.6%

  54. #54 Space Codex
    69% matchVery Positive81% of 412 reviews2016
    Dev: takk
    Windows
    Median: 3.0 hrsMean: 3.4 hrs≥1hr: 86%

    Space Codex is a casual retro arcade minimal awesome top-down shooter featuring waves of enemy spaceships with different attacks in what is, literally, a bullet hell. To beat them, you will have power-up options available through the map. The game only gets harder. How long can you stay alive?

    Why similar: Shoot 'Em Up 42.1%, Casual 21.8%, Retro 20.3%, Arcade 15.8%

  55. #55 Genome Guardian 2
    63% matchVery Positive98% of 194 reviews2026
    Dev: Alpherior
    Windows

    COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!

    Why similar: Science 45.5%, Top-Down Shooter 22.3%, Shooter 17%, Action 7.9%, Casual 7.3%

  56. #56 Space Elite Force II
    68% matchVery Positive88% of 109 reviews2020
    Dev: Rising Moon Games
    Windows · Linux

    Space Elite Force II is a frenetic space-shooter with weapon customization and insane bosses battles. Embark in your ship and fight for the survival of the human race!

    Why similar: Shoot 'Em Up 27.7%, Arcade 16.5%, Space 12.7%, Shooter 10.6%, Retro 7.9%

  57. #57 Sus Virus Amogus
    66% matchVery Positive81% of 62 reviews2024
    Dev: Galactic GeckonPub: Galactic Geckon
    Windows

    Sus Virus Amogus is a sci-fi action-roguelike game. A lost scientist on an endless space station battles hostile soldiers and robots, using random weapons with unique effects to progress deeper into the station.

    Why similar: Shoot 'Em Up 27.6%, Science 23.8%, Top-Down Shooter 19.3%, Shooter 14.5%, Action 4.9%

  58. #58 BYTEPATH
    67% matchVery Positive92% of 312 reviews2018
    Dev: a327ex
    Windows · Linux
    Median: 1.0 hrsMean: 3.0 hrs≥1hr: 50%

    BYTEPATH is a replayable arcade shooter with a focus on build theorycrafting. Use a massive skill tree, many classes and ships to create your own builds and defeat an ever increasing amount of enemies.

    Why similar: Retro 37.2%, Action 25.3%, Casual 23.4%, 2D 14.1%

  59. #59 Blast Off Far Away
    67% matchVery Positive95% of 56 reviews2022
    Dev: C405Pub: DigiPen Institute of Technology
    Windows

    Shoot to move, move to live, live to shoot! Blast Off Far Away (B.O.F.A.) is a space-themed, top-down arena shooter, with a focus on fast-paced arcade-esque gameplay, with the unique twist where movement is limited through the use of the player's gun.

    Why similar: Shoot 'Em Up 35%, Arcade 19%, Shooter 18.7%, Space 8.5%, Action 6.6%

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Games Like Welcome To Your Immune System

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