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Games Like Caduceus Quest

60+ similar titles based on shared tags and player behavior. Themes include Medical Sim, Education, Simulation, Singleplayer.

Caduceus Quest header art

Caduceus Quest is a single-player RPG in which players use the scientific process to solve a medical mystery that poses a growing threat to your small town. You must learn from and enlist the help of local science professionals and complete strategic mini-games to identify and resolve the threat.

Reviews: 1 user reviews — 100% — of 1 reviews
Released: 2025-01-10
Developer: Resilient Games Studio, LLC
Genres: RPG
Platforms: Windows

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    97% matchNo user reviews
    Dev: Viral Studios
    Windows

    S4Game aims to provide health professionals with an innovative approach to acquire soft skills to foster their professional development. Their main learning objective is the acquisition of soft skills required during work in an operating room, such as communication or teamwork.

    Why similar: Medical Sim 58.6%, Education 19.8%, Investigation 18.6%, Choices Matter 2.8%, Singleplayer 0.3%

  2. #2 小邦迪的奇妙冒险
    95% matchPositive88% of 17 reviews2021
    Dev: Puyuan YePub: Band-Aid
    Windows · Mac

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    Why similar: Medical Sim 61.2%, Education 20.7%, RPG 14.8%, Linear 3.1%, Singleplayer 0.2%

  3. #3 RoboDoc Jr
    94% matchNo user reviews2025
    Dev: Marion SurgicalPub: Sketchy Neurons
    Windows

    A fun space adventure game where kids become alien medics! Use cool futuristic tools to help friendly aliens across 12 exciting missions. Solve puzzles, fix alien tech, and save the day with steady hands and smart thinking!

    Why similar: Medical Sim 72.6%, Education 27.2%, Singleplayer 0.2%

  4. #4 Vital Signs: Emergency Department
    93% matchMixed56% of 73 reviews2020
    Dev: BreakAway Games
    Windows · Mac

    Play a doctor in Vital Signs: Emergency Department and challenge your medical knowledge to help treat a wide array of cases who come into the ER.

    Why similar: Medical Sim 62.9%, Education 23.7%, Hand-drawn 6.1%, Choices Matter 4%, Text-Based 2.9%

  5. #5 疑義照会ウォーズ
    92% matchMostly Negative30% of 20 reviews2021
    Dev: 薬学ゲーム開発プロジェクト
    Windows

    This is a full-fledged adventure game (selectable type) based on the theme of the pharmacist's job, "checking prescription. Determine if the prescription is correct, and if it is, make a "Questionable Inquiry" to the doctor!

    Why similar: Medical Sim 74.7%, Education 25%, Singleplayer 0.3%

  6. #6 First Steps in Child Developmental Support
    91% match9 user reviews100% of 9 reviews2025
    Dev: エムテラス
    Windows

    Yuuka, a nursing student, is doing a summer practicum at a Child Development Support Center. Explore the facility in a role-playing format and experience child support activities. Learn about medical care, therapeutic interventions, and home healthcare over three days.

    Why similar: Medical Sim 70%, Education 25.7%, Choices Matter 4%, Singleplayer 0.2%

  7. #7 Medical Diagnostic Simulator
    91% matchMostly Negative25% of 16 reviews2024
    Dev: Arktos Cat
    Windows

    Play as a general practitioner in this text-based medical simulation game. Consult, examine, and diagnose your patients in your own medical practice.

    Why similar: Medical Sim 65%, Education 30.7%, Text-Based 3.9%, Singleplayer 0.4%

  8. #8 First Steps in the NICU (Discovery edition)
    89% match6 user reviews100% of 6 reviews2025
    Dev: エムテラス
    Windows

    Welcome to “First NICU Experience”! Experience neonatal care in this serious game. As a nursing student, work with medical staff and families to care for infants and tackle post-discharge challenges. With interactive choices and story-driven gameplay, learn key skills in 1 hour.

    Why similar: Medical Sim 64.9%, Education 30.5%, Choices Matter 4.3%, Singleplayer 0.3%

  9. #9 Pompiers Simulator
    89% match4 user reviews100% of 4 reviews2025
    Dev: Vincent TartarPub: Oasis Video Games
    Windows

    You’re not a firefighter, but you dream of experiencing the intensity of a real emergency rescue operation? Pompiers Simulator puts you at the heart of first aid missions, in the shoes of a responder, within a simulation designed by real firefighters.

    Why similar: Medical Sim 71.2%, Education 24.9%, Choices Matter 3.7%, Singleplayer 0.2%

  10. #10 VR TKA Surgery Simulator
    87% match2 user reviews0% of 2 reviews2024
    Dev: Kliniker
    Windows

    Get ready to learn all the subtleties of the surgery by practicing it in the applied VR TKA training by Prof. Dr. Ertugrul Aksahin, one of the world's leading orthopedic surgeons!

    Why similar: Medical Sim 67.7%, Education 32%, Singleplayer 0.3%

  11. #11 中医模拟传承人
    86% matchPositive86% of 14 reviews2024
    Dev: guizhi0011
    Windows

    A game where everyone can learn traditional Chinese medicine.

    Why similar: Medical Sim 71.1%, Education 28.6%, Singleplayer 0.3%

  12. #12 Elixir
    85% matchPositive93% of 42 reviews2024
    Dev: Moxu Projects
    Windows

    Welcome to Elixir, a 2D strategic puzzle experience. Become an ancient alchemist with a mysterious past to unlock. Explore & find lost souls who need your help. Uncover Elixirs and experiment on them, and yourself. Embark on a dark journey to solve puzzles, unlock recipes and unearth hidden secrets.

    Why similar: Medical Sim 58.9%, Investigation 20.3%, Mystery 7.4%, Hand-drawn 7%, Exploration 6.2%

  13. #13 WirtschaftsWoche Virtual Reality
    86% match3 user reviews67% of 3 reviews2021
    Dev: Michael BertramPub: Handelsblatt GmbH – ein Unternehmen der Handelsblatt Media Group GmbH & Co. KG
    Windows

    Virtual Reality Simulation Experience in Virtual Reality how an electric car is created, or save a person's life in the hospital of the future.

    Why similar: Medical Sim 45.8%, Education 22.6%, Science 16.4%, Interactive Fiction 10.6%, Exploration 4.3%

  14. #14 On Call
    84% match9 user reviews90% of 10 reviews2023
    Dev: CelleC Games
    Windows · Mac

    On Call is a visual novel that takes you through a 3-day rotation at Merritt General Hospital. Build trust with your patients and their families to get them on the road to recovery. Manage your own stress while confronting these challenges or you may just crack under the pressure.

    Why similar: Medical Sim 53.5%, Interactive Fiction 20.1%, Education 18.6%, Choices Matter 3.8%, Linear 2.7%

  15. #15 Physician Simulator
    83% matchNo user reviews
    Dev: Pavel Shishkin
    Windows · Mac · Linux

    A district physician simulator. See patients, review lab results, make diagnoses and write prescriptions. Real doctors say they recognize themselves. Every decision has consequences.

    Why similar: Medical Sim 50.8%, Education 28.6%, RPG 18%, Choices Matter 2.4%, Singleplayer 0.1%

  16. #16 Kellogg's Gut Bacteria Reef
    82% matchPositive84% of 50 reviews2021
    Dev: NAKATOMIPub: KELLOGG
    Windows

    Explore the human gut like never before!

    Why similar: Medical Sim 66.5%, Education 33.2%, Singleplayer 0.3%

  17. #17 Valley General Hospital: NiVR
    82% match2 user reviews50% of 2 reviews2021
    Dev: Valley General
    Windows

    An exciting new approach to training and simulation in Healthcare.

    Why similar: Medical Sim 72.7%, Education 24%, Choices Matter 3.2%, Singleplayer 0.2%

  18. #18 Bacterium / 生命之旅
    81% matchPositive84% of 49 reviews2018
    Dev: Dragon Whisper GamePub: Zodiac Interactive
    Windows

    In the coming decades, a huge breakthrough in nano-medical technology will bring a new light to cure terminally ill patients. As a nano-robot operator, you will be involved in a battle between nanobots and diseases!

    Why similar: Medical Sim 85.2%, RPG 14.8%

  19. #19 Animal Doctor
    81% matchMixed41% of 39 reviews2021
    Dev: Caipirinha GamesPub: Toplitz Productions
    Windows

    Make your dreams come true with Animal Doctor! Would you like to spend your life caring for animals? With Animal Doctor you will be surrounded by animal friends and pets.

    Why similar: Medical Sim 52.8%, Education 21%, Investigation 17.5%, RPG 8.7%

  20. #20 Mask of the Plague Doctor
    79% matchVery Positive87% of 63 reviews2020
    Dev: Choice of Games
    Windows · Mac · Linux

    Stop a deadly plague in a medieval fantasy tale of swords and surgery! Unearth medical knowledge, prevent the town’s purge, or plot your own escape.

    Why similar: Medical Sim 58.8%, Interactive Fiction 19.2%, RPG 17.6%, Text-Based 3.9%, Singleplayer 0.4%

  21. #21 My Universe - Doctors & Nurses
    79% matchMostly Negative29% of 14 reviews2022
    Dev: It Matters GamesPub: Microids
    Windows · Mac

    Take turns to play either a doctor or nurse. Diagnose illnesses and infections so as to treat and help your many patients. Set out on an adventure in a buzzing hospital environment. Meet all sorts of different characters and discover a story full of surprises.

    Why similar: Medical Sim 76.8%, Education 22.8%, Singleplayer 0.4%

  22. #22 型神:初见
    78% matchNo user reviews
    Dev: 戏宫科技
    Windows

    全球首款医美手术模拟与视觉小说相结合的游戏!你将通过神奇的医美技术改变命运,体验30场精密手术,揭开时间与美丽背后的秘密。你的每一次操作,都在重塑他人的人生。

    Why similar: Medical Sim 77.5%, Interactive Fiction 19.5%, Story Rich 2.6%, Singleplayer 0.3%

  23. #23 Surgeon Simulator VR: Meet The Medic
    78% matchMostly Positive77% of 580 reviews2016
    Dev: Bossa Studios
    Windows
    Median: 18 minMean: 1.7 hrs≥1hr: 14%

    Surgeon Simulator VR: Meet the Medic – be the Medic and operate on the Heavy in this free and exclusive teaser for the HTC Vive!

    Why similar: Medical Sim 100%

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    77% matchVery Positive94% of 52 reviews2021
    Dev: The VALIDATE Network
    Windows · Mac

    Welcome to Your Immune System is an addictive retro arcade-style video game where you defend human cells from invading bacteria. Use all the weapons in your arsenal from macrophages, killer T cells, to cytokines and learn how these work in real life.

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  25. #25 SimShock2025
    75% match7 user reviews75% of 8 reviews2025
    Dev: Pablo Kessler SaizPub: Pablo Kessler
    Windows · Mac

    SimShock2025 is a free, bilingual (EN/ES) hemodynamic shock simulator. Treat cardiogenic, hemorrhagic, and septic shock using real drugs and interventions. Written in PureBasic, available for Mac and Windows. Apple-signed and notarized.

    Why similar: Medical Sim 63.9%, Education 32%, Text-Based 2.6%, Story Rich 1.4%, Singleplayer 0.2%

  26. #26 Ministry of Pandemic
    77% match5 user reviews60% of 5 reviews2022
    Dev: Ceyhan KapusuzPub: Cookie Mechanics
    Windows

    Ministry of Pandemic is a strategy and simulation game that forces social and economic balance during the pandemic. Formulate your strategy for survival while keeping all aspects of society steady.

    Why similar: Medical Sim 45.2%, Education 17.6%, Turn-Based Strategy 11%, Science 10.3%, 2.5D 8.4%

  27. #27 Death at Fleming Manor
    76% matchNo user reviews2026
    Dev: SUPERTHUMb
    Windows

    "Your job is to write the death certificate." Investigate a mysterious death in a grand British manor, 1959. Explore eerie scenes and complete forensic documents like death certificates and medical reports. Stylish 1960s detective comic art. Perfect for fans of vintage whodunits.

    Why similar: Medical Sim 37.6%, Investigation 21.7%, Mystery 11.7%, Interactive Fiction 11%, Hand-drawn 8.2%

  28. #28 Food Decisions
    76% matchMixed68% of 22 reviews2021
    Dev: BPPub: FIT Talent Games
    Windows

    FOOD DECISIONS is an educational game for healthy nutrition. Explore food in a lab, a restaurant, a supermarket, a kitchen, and more. Battle your friends in mini games like Food Olympics and Health Chess. Live a day in an open world and get feedback on your diet at the end of the day.

    Why similar: Medical Sim 46.3%, Education 27.6%, Science 14.8%, Choices Matter 6%, Exploration 5.3%

  29. #29 Psyhonds
    74% match5 user reviews80% of 5 reviews2026
    Dev: Meriteri GamesPub: Terrabyte Games
    Windows

    A satirical mental hospital survival simulator: control four unstable characters, craft from junk, forge dubious alliances, communicate with patients and staff, and choose between a quiet life in a ward, a riot, or a risky escape to freedom.

    Why similar: Medical Sim 81.8%, RPG 6.8%, Hand-drawn 5.6%, Choices Matter 4%, Story Rich 1.6%

  30. #30 Medical verdict
    75% matchMixed57% of 53 reviews2018
    Dev: Volokitin Andrey
    Windows

    Here is a fun simulator of passing a medical examination in the Chelyabinsk clinic with realistic graphics and interesting gameplay! Take the coronavirus test! Collect as many virtual health points as you can, but remember ... this is just a game!

    Why similar: Medical Sim 100%

  31. #31 Cells of Immunity
    73% matchMostly Positive72% of 25 reviews2022
    Dev: Nova Empyrean
    Windows

    Become a young white blood cell in training and learn how they mature and fight against invading pathogens. Team up with other types of cells, with unique strengths and weaknesses, and overcome disease for good. To serve and protect the human body at all costs.

    Why similar: Medical Sim 51.6%, Education 20.5%, Science 15.6%, RPG 7.5%, Linear 3%

  32. #32 Pestis
    74% matchMostly Positive70% of 108 reviews2018
    Dev: DIEDEMOR STUDIO GAMESPub: Laush Studio
    Windows

    A young Plague Doctor, only to learn that the Academy sent to a small village, which, like the whole country is gripped by plague

    Why similar: Medical Sim 48.9%, Education 22.1%, Science 14.4%, Hand-drawn 6.2%, Exploration 4.6%

  33. #33 Virulence
    73% matchNo user reviews
    Dev: Kamal Patel
    Windows

    Virulence is a 2D top down metroidvania / Zelda-like action RPG, where the player will explore the human body as a virus species and infect other cells in order to survive. The player can control an individual virus or command a whole population.

    Why similar: Medical Sim 70.1%, Science 14.3%, RPG 8.8%, Exploration 6.8%, Singleplayer 0.1%

  34. #34 Breeding Hospital
    71% match3 user reviews67% of 3 reviews2025
    Dev: びゅびゅ丸★
    Windows

    This is a hospital simulator for those aged 18 and over. You can have various experiences with multiple female nurses. The nurses will satisfy your sexual desires according to your choices. However, if you impregnate a girl, the nurse will bear all the responsibility.

    Why similar: Medical Sim 80.5%, Turn-Based Strategy 15.7%, Choices Matter 3.7%, Singleplayer 0.2%

  35. #35 Alma
    73% match4 user reviews100% of 4 reviews2021
    Dev: Francesca PalamaraPub: Galaxy Cereal Studios LLC
    Windows · Mac

    Alma is an interactive narrative that captures the tension of work-life balance for healthcare workers. Play as Alma, a caring mother and pediatric nurse, who must tend to both aspects of her life. Alma is a story of self-care and the struggle to find balance in an imbalanced life.

    Why similar: Medical Sim 52.6%, Education 25.2%, Interactive Fiction 15%, Hand-drawn 7.1%

  36. #36 Our Town
    72% matchNo user reviews
    Dev: Fish Truck Studios
    Windows

    Our Town is a 2.5D story-driven, horror investigation RPG set during a fictionalized 60's America. Deliver newspapers as you uncover secrets of the mundane. Through point-and-click investigations and visual-novel dialogue, discover the underbelly of this bustling town—if any.

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  37. #37 Reanimation Inc.
    72% matchVery Positive84% of 129 reviews2019
    Dev: Dmitrii Lomakin
    Windows

    Reanimation inc is a completely realistic simulation - real urgent conditions and diseases, real protocols of care used in an ambulance, realistic simulation of the body! Do you like realistic games about medicine and simulators, games you need to think about? You 'll be happy!

    Why similar: Medical Sim 100%

  38. #38 Do No Harm
    69% matchMostly Positive74% of 873 reviews2025
    Dev: Darts Games
    Windows
    Median: 2.5 hrsMean: 5.9 hrs≥1hr: 77%

    Lovecraftian Doctor Simulator. Diagnose patients by analyzing unsettling symptoms and treat them using your Book of Medicine. Make moral choices — decide who to save or kill, discover whom to trust, and unlock multiple endings! Can you endure 30 days of perilous decisions?

    Why similar: Medical Sim 61.9%, Investigation 19.6%, Mystery 10.4%, Choices Matter 5.8%, Story Rich 2.3%

  39. #39 Medic Simulator
    71% matchNo user reviews
    Dev: Eathrabaria
    Windows

    Become a doctor and treat patients in every area of medicine. Become a cardiologist, psychiatrist, dentist, dermatologist, oncologist, surgeon, ophthalmologist, neurologist…!

    Why similar: Medical Sim 74.5%, Science 20.7%, Choices Matter 4.5%, Singleplayer 0.3%

  40. #40 Heart's Medicine - Hospital Heat
    70% matchVery Positive96% of 364 reviews2017
    Dev: Blue GiraffePub: GameHouse
    Windows · Mac
    Median: 5.1 hrsMean: 8.7 hrs≥1hr: 93%

    The long awaited sequel to "Heart's Medicine - Time to Heal". An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring doctor at Little Creek Hospital!

    Why similar: Medical Sim 98.8%, Story Rich 1.2%

  41. #41 Queen Naeja's Desires
    69% match1 user reviews100% of 1 reviews2025
    Dev: SongGame
    Windows

    Where your choices shape an epic narrative. Step into the shoes of Yafen, a soul betrayed by her own era and reborn as the queen consort to the bad-boy Prince Yonglie LieHong of Naer Kingdom.

    Why similar: Medical Sim 59.3%, Interactive Fiction 14.9%, 2.5D 11.5%, RPG 8%, Exploration 6.3%

  42. #42 FORENSIC - M.E. Protocol
    70% matchNo user reviews2026
    Dev: k148 Game StudioPub: JanduSoft
    Windows

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  43. #43 Human Constructor VR
    71% match3 user reviews67% of 3 reviews2020
    Dev: Exxit
    Windows

    Human Constructor VR is a virtual reality application designed for detailed study of the human structure and individual organs, bones, and muscles. This application contains only the anatomy of the male human body.

    Why similar: Medical Sim 93.4%, Education 6.2%, Singleplayer 0.4%

  44. #44 Dr. Cares - Amy's Pet Clinic
    70% matchMostly Positive79% of 75 reviews2018
    Dev: NitrealPub: GameHouse
    Windows · Mac

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    Why similar: Medical Sim 100%

  45. #45 Life on the Edge
    68% matchVery Positive91% of 95 reviews2022
    Dev: LOTE Team
    Windows · Mac

    Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!

    Why similar: Medical Sim 47.1%, Education 28.1%, Science 24.7%, Singleplayer 0.1%

  46. #46 Opawration!
    69% matchNo user reviews
    Dev: chinchingames
    Windows

    A 2D, veterinarian horror game. In this game, select the appropriate treatment and treat patients with topical products injections, surgeries. Treat patients over the course of 7 days, using the in-game computer to research the best treatment option. Playtime is 30 minutes.

    Why similar: Medical Sim 85.6%, Hand-drawn 7.4%, Choices Matter 6.7%, Singleplayer 0.3%

  47. #47 MediSim: Emergency Response
    68% matchNo user reviews
    Dev: Mehmet Hilmi Değirmenci
    Windows

    As a young doctor, save lives in emergencies, advance from a health center to a major hospital, and manage your own facility. Perform first aid, and diagnostics, take on ambulance and helicopter missions, and build your medical team. A realistic medical simulation where every decision matters!

    Why similar: Medical Sim 81%, Education 18.8%, Singleplayer 0.2%

  48. #48 Heart's Medicine - Time to Heal
    68% matchVery Positive94% of 878 reviews2016
    Dev: Blue GiraffePub: GameHouse
    Windows · Mac
    Median: 6.0 hrsMean: 12.1 hrs≥1hr: 92%

    An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring surgeon at Little Creek Hospital!

    Why similar: Medical Sim 98.2%, Story Rich 1.6%, Singleplayer 0.3%

  49. #49 Animal Rescue
    67% matchNo user reviews
    Dev: Spirit Games Studio
    Windows

    Animal Rescue is a unique game in which you play the role of a field rescuer-vet. Face the elements of nature and save innocent animals! Their life depends entirely on you! Someone has to save them! Will it be you?

    Why similar: Medical Sim 65.8%, Education 27.2%, Exploration 7%, Singleplayer 0.1%

  50. #50 50 Minutes 'Til Impact
    65% matchPositive93% of 28 reviews2025
    Dev: Atomic Baby GamesPub: John Paul the Great Catholic University
    Windows

    50 Minutes 'Til Impact is set in a retro-futuristic world aboard an advanced, yet luxurious space train! It's a linear narrative adventure where players utilize 3D exploration, code solving, and visual novel interactions to do whatever they can to save everyone on board before time runs out.

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  51. #51 Accident
    66% matchMostly Positive77% of 1,703 reviews2021
    Dev: Duality Games
    Windows
    Median: 1.2 hrsMean: 2.4 hrs≥1hr: 56%

    Become a journalist who researches old car accident cases. Help victims and perform first aid, obtain evidence and reconstruct the events to discover what really happened.

    Why similar: Medical Sim 56.2%, Education 23.5%, Investigation 16.4%, Choices Matter 3.7%, Singleplayer 0.3%

  52. #52 Lifeguard Simulator
    67% matchNo user reviews2026
    Dev: FreeMind S.A.
    Windows

    Guard the beach, react fast, and save lives using quads, jet skis, motorboats, drones, and a helicopter. Patrol the bay, help those in need and uncover a hidden criminal intrigue beneath the waves.

    Why similar: Medical Sim 62%, Education 26.5%, Exploration 5.9%, Choices Matter 5.2%, Singleplayer 0.4%

  53. #53 Flesh Blossom
    67% matchNo user reviews
    Dev: Crimson Pearl Games
    Windows

    You are Doctor Parsnip Green, the first and last line of defense against a grotesquely beautiful epidemic. Make difficult choices as you investigate the disease’s origin, operate on patients, and fight to save those you love - all while managing your own dwindling sanity.

    Why similar: Medical Sim 45.1%, Interactive Fiction 13.6%, RPG 11.3%, Investigation 8.1%, Choices Matter 7.7%

Based on tag similarity + player behavior
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