- #1 S4Game
97% matchNo user reviews
Dev: Viral Studios
Windows
S4Game aims to provide health professionals with an innovative approach to acquire soft skills to foster their professional development. Their main learning objective is the acquisition of soft skills required during work in an operating room, such as communication or teamwork.
Why similar: Medical Sim 58.6% ★, Education 19.8%, Investigation 18.6%, Choices Matter 2.8%, Singleplayer 0.3%
- #2 小邦迪的奇妙冒险
95% matchPositive88% of 17 reviews2021
Dev: Puyuan YePub: Band-Aid
Windows · Mac
在《小邦迪的奇妙冒险》中与小邦迪一同学习急救知识,拯救吴家于各种急症之中。
Why similar: Medical Sim 61.2% ★, Education 20.7%, RPG 14.8%, Linear 3.1%, Singleplayer 0.2%
- #3 RoboDoc Jr
94% matchNo user reviews2025
Dev: Marion SurgicalPub: Sketchy Neurons
Windows
A fun space adventure game where kids become alien medics! Use cool futuristic tools to help friendly aliens across 12 exciting missions. Solve puzzles, fix alien tech, and save the day with steady hands and smart thinking!
Why similar: Medical Sim 72.6% ★, Education 27.2%, Singleplayer 0.2%
- #4 Vital Signs: Emergency Department
93% matchMixed56% of 73 reviews2020
Dev: BreakAway Games
Windows · Mac
Play a doctor in Vital Signs: Emergency Department and challenge your medical knowledge to help treat a wide array of cases who come into the ER.
Why similar: Medical Sim 62.9% ★, Education 23.7%, Hand-drawn 6.1%, Choices Matter 4%, Text-Based 2.9%
- #5 疑義照会ウォーズ
92% matchMostly Negative30% of 20 reviews2021
Dev: 薬学ゲーム開発プロジェクト
Windows
This is a full-fledged adventure game (selectable type) based on the theme of the pharmacist's job, "checking prescription. Determine if the prescription is correct, and if it is, make a "Questionable Inquiry" to the doctor!
Why similar: Medical Sim 74.7% ★, Education 25%, Singleplayer 0.3%
- #6 First Steps in Child Developmental Support
91% match9 user reviews100% of 9 reviews2025
Dev: エムテラス
Windows
Yuuka, a nursing student, is doing a summer practicum at a Child Development Support Center. Explore the facility in a role-playing format and experience child support activities. Learn about medical care, therapeutic interventions, and home healthcare over three days.
Why similar: Medical Sim 70% ★, Education 25.7%, Choices Matter 4%, Singleplayer 0.2%
- #7 Medical Diagnostic Simulator
91% matchMostly Negative25% of 16 reviews2024
Dev: Arktos Cat
Windows
Play as a general practitioner in this text-based medical simulation game. Consult, examine, and diagnose your patients in your own medical practice.
Why similar: Medical Sim 65% ★, Education 30.7%, Text-Based 3.9%, Singleplayer 0.4%
- #8 First Steps in the NICU (Discovery edition)
89% match6 user reviews100% of 6 reviews2025
Dev: エムテラス
Windows
Welcome to “First NICU Experience”! Experience neonatal care in this serious game. As a nursing student, work with medical staff and families to care for infants and tackle post-discharge challenges. With interactive choices and story-driven gameplay, learn key skills in 1 hour.
Why similar: Medical Sim 64.9% ★, Education 30.5%, Choices Matter 4.3%, Singleplayer 0.3%
- #9 Pompiers Simulator
89% match4 user reviews100% of 4 reviews2025
Dev: Vincent TartarPub: Oasis Video Games
Windows
You’re not a firefighter, but you dream of experiencing the intensity of a real emergency rescue operation? Pompiers Simulator puts you at the heart of first aid missions, in the shoes of a responder, within a simulation designed by real firefighters.
Why similar: Medical Sim 71.2% ★, Education 24.9%, Choices Matter 3.7%, Singleplayer 0.2%
- #10 VR TKA Surgery Simulator
87% match2 user reviews0% of 2 reviews2024
Dev: Kliniker
Windows
Get ready to learn all the subtleties of the surgery by practicing it in the applied VR TKA training by Prof. Dr. Ertugrul Aksahin, one of the world's leading orthopedic surgeons!
Why similar: Medical Sim 67.7% ★, Education 32%, Singleplayer 0.3%
- #11 中医模拟传承人
86% matchPositive86% of 14 reviews2024
Dev: guizhi0011
Windows
A game where everyone can learn traditional Chinese medicine.
Why similar: Medical Sim 71.1% ★, Education 28.6%, Singleplayer 0.3%
- #12 Elixir
85% matchPositive93% of 42 reviews2024
Dev: Moxu Projects
Windows
Welcome to Elixir, a 2D strategic puzzle experience. Become an ancient alchemist with a mysterious past to unlock. Explore & find lost souls who need your help. Uncover Elixirs and experiment on them, and yourself. Embark on a dark journey to solve puzzles, unlock recipes and unearth hidden secrets.
Why similar: Medical Sim 58.9% ★, Investigation 20.3%, Mystery 7.4%, Hand-drawn 7%, Exploration 6.2%
- #13 WirtschaftsWoche Virtual Reality
86% match3 user reviews67% of 3 reviews2021
Dev: Michael BertramPub: Handelsblatt GmbH – ein Unternehmen der Handelsblatt Media Group GmbH & Co. KG
Windows
Virtual Reality Simulation Experience in Virtual Reality how an electric car is created, or save a person's life in the hospital of the future.
Why similar: Medical Sim 45.8% ★, Education 22.6%, Science 16.4% ★, Interactive Fiction 10.6%, Exploration 4.3%
- #14 On Call
84% match9 user reviews90% of 10 reviews2023
Dev: CelleC Games
Windows · Mac
On Call is a visual novel that takes you through a 3-day rotation at Merritt General Hospital. Build trust with your patients and their families to get them on the road to recovery. Manage your own stress while confronting these challenges or you may just crack under the pressure.
Why similar: Medical Sim 53.5% ★, Interactive Fiction 20.1%, Education 18.6%, Choices Matter 3.8%, Linear 2.7%
- #15 Physician Simulator
83% matchNo user reviews
Dev: Pavel Shishkin
Windows · Mac · Linux
A district physician simulator. See patients, review lab results, make diagnoses and write prescriptions. Real doctors say they recognize themselves. Every decision has consequences.
Why similar: Medical Sim 50.8% ★, Education 28.6%, RPG 18%, Choices Matter 2.4%, Singleplayer 0.1%
- #16 Kellogg's Gut Bacteria Reef
82% matchPositive84% of 50 reviews2021
Dev: NAKATOMIPub: KELLOGG
Windows
Explore the human gut like never before!
Why similar: Medical Sim 66.5% ★, Education 33.2%, Singleplayer 0.3%
- #17 Valley General Hospital: NiVR
82% match2 user reviews50% of 2 reviews2021
Dev: Valley General
Windows
An exciting new approach to training and simulation in Healthcare.
Why similar: Medical Sim 72.7% ★, Education 24%, Choices Matter 3.2%, Singleplayer 0.2%
- #18 Bacterium / 生命之旅
81% matchPositive84% of 49 reviews2018
Dev: Dragon Whisper GamePub: Zodiac Interactive
Windows
In the coming decades, a huge breakthrough in nano-medical technology will bring a new light to cure terminally ill patients. As a nano-robot operator, you will be involved in a battle between nanobots and diseases!
Why similar: Medical Sim 85.2% ★, RPG 14.8%
- #19 Animal Doctor
81% matchMixed41% of 39 reviews2021
Dev: Caipirinha GamesPub: Toplitz Productions
Windows
Make your dreams come true with Animal Doctor! Would you like to spend your life caring for animals? With Animal Doctor you will be surrounded by animal friends and pets.
Why similar: Medical Sim 52.8% ★, Education 21%, Investigation 17.5%, RPG 8.7%
- #20 Mask of the Plague Doctor
79% matchVery Positive87% of 63 reviews2020
Dev: Choice of Games
Windows · Mac · Linux
Stop a deadly plague in a medieval fantasy tale of swords and surgery! Unearth medical knowledge, prevent the town’s purge, or plot your own escape.
Why similar: Medical Sim 58.8% ★, Interactive Fiction 19.2%, RPG 17.6%, Text-Based 3.9%, Singleplayer 0.4%
- #21 My Universe - Doctors & Nurses
79% matchMostly Negative29% of 14 reviews2022
Dev: It Matters GamesPub: Microids
Windows · Mac
Take turns to play either a doctor or nurse. Diagnose illnesses and infections so as to treat and help your many patients. Set out on an adventure in a buzzing hospital environment. Meet all sorts of different characters and discover a story full of surprises.
Why similar: Medical Sim 76.8% ★, Education 22.8%, Singleplayer 0.4%
- #22 型神:初见
78% matchNo user reviews
Dev: 戏宫科技
Windows
全球首款医美手术模拟与视觉小说相结合的游戏!你将通过神奇的医美技术改变命运,体验30场精密手术,揭开时间与美丽背后的秘密。你的每一次操作,都在重塑他人的人生。
Why similar: Medical Sim 77.5% ★, Interactive Fiction 19.5%, Story Rich 2.6%, Singleplayer 0.3%
- #23 Surgeon Simulator VR: Meet The Medic
78% matchMostly Positive77% of 580 reviews2016
Dev: Bossa Studios
Windows
Median: 18 minMean: 1.7 hrs≥1hr: 14%
Surgeon Simulator VR: Meet the Medic – be the Medic and operate on the Heavy in this free and exclusive teaser for the HTC Vive!
Why similar: Medical Sim 100% ★
- #24 Welcome To Your Immune System
77% matchVery Positive94% of 52 reviews2021
Dev: The VALIDATE Network
Windows · Mac
Welcome to Your Immune System is an addictive retro arcade-style video game where you defend human cells from invading bacteria. Use all the weapons in your arsenal from macrophages, killer T cells, to cytokines and learn how these work in real life.
Why similar: Medical Sim 57.1% ★, Education 26%, Science 16.7% ★, Singleplayer 0.3%
- #25 SimShock2025
75% match7 user reviews75% of 8 reviews2025
Dev: Pablo Kessler SaizPub: Pablo Kessler
Windows · Mac
SimShock2025 is a free, bilingual (EN/ES) hemodynamic shock simulator. Treat cardiogenic, hemorrhagic, and septic shock using real drugs and interventions. Written in PureBasic, available for Mac and Windows. Apple-signed and notarized.
Why similar: Medical Sim 63.9% ★, Education 32%, Text-Based 2.6%, Story Rich 1.4%, Singleplayer 0.2%
- #26 Ministry of Pandemic
77% match5 user reviews60% of 5 reviews2022
Dev: Ceyhan KapusuzPub: Cookie Mechanics
Windows
Ministry of Pandemic is a strategy and simulation game that forces social and economic balance during the pandemic. Formulate your strategy for survival while keeping all aspects of society steady.
Why similar: Medical Sim 45.2% ★, Education 17.6%, Turn-Based Strategy 11%, Science 10.3% ★, 2.5D 8.4%
- #27 Death at Fleming Manor
76% matchNo user reviews2026
Dev: SUPERTHUMb
Windows
"Your job is to write the death certificate." Investigate a mysterious death in a grand British manor, 1959. Explore eerie scenes and complete forensic documents like death certificates and medical reports. Stylish 1960s detective comic art. Perfect for fans of vintage whodunits.
Why similar: Medical Sim 37.6% ★, Investigation 21.7%, Mystery 11.7%, Interactive Fiction 11%, Hand-drawn 8.2%
- #28 Food Decisions
76% matchMixed68% of 22 reviews2021
Dev: BPPub: FIT Talent Games
Windows
FOOD DECISIONS is an educational game for healthy nutrition. Explore food in a lab, a restaurant, a supermarket, a kitchen, and more. Battle your friends in mini games like Food Olympics and Health Chess. Live a day in an open world and get feedback on your diet at the end of the day.
Why similar: Medical Sim 46.3% ★, Education 27.6%, Science 14.8% ★, Choices Matter 6%, Exploration 5.3%
- #29 Psyhonds
74% match5 user reviews80% of 5 reviews2026
Dev: Meriteri GamesPub: Terrabyte Games
Windows
A satirical mental hospital survival simulator: control four unstable characters, craft from junk, forge dubious alliances, communicate with patients and staff, and choose between a quiet life in a ward, a riot, or a risky escape to freedom.
Why similar: Medical Sim 81.8% ★, RPG 6.8%, Hand-drawn 5.6%, Choices Matter 4%, Story Rich 1.6%
- #30 Medical verdict
75% matchMixed57% of 53 reviews2018
Dev: Volokitin Andrey
Windows
Here is a fun simulator of passing a medical examination in the Chelyabinsk clinic with realistic graphics and interesting gameplay! Take the coronavirus test! Collect as many virtual health points as you can, but remember ... this is just a game!
Why similar: Medical Sim 100% ★
- #31 Cells of Immunity
73% matchMostly Positive72% of 25 reviews2022
Dev: Nova Empyrean
Windows
Become a young white blood cell in training and learn how they mature and fight against invading pathogens. Team up with other types of cells, with unique strengths and weaknesses, and overcome disease for good. To serve and protect the human body at all costs.
Why similar: Medical Sim 51.6% ★, Education 20.5%, Science 15.6% ★, RPG 7.5%, Linear 3%
- #32 Pestis
74% matchMostly Positive70% of 108 reviews2018
Dev: DIEDEMOR STUDIO GAMESPub: Laush Studio
Windows
A young Plague Doctor, only to learn that the Academy sent to a small village, which, like the whole country is gripped by plague
Why similar: Medical Sim 48.9% ★, Education 22.1%, Science 14.4% ★, Hand-drawn 6.2%, Exploration 4.6%
- #33 Virulence
73% matchNo user reviews
Dev: Kamal Patel
Windows
Virulence is a 2D top down metroidvania / Zelda-like action RPG, where the player will explore the human body as a virus species and infect other cells in order to survive. The player can control an individual virus or command a whole population.
Why similar: Medical Sim 70.1% ★, Science 14.3% ★, RPG 8.8%, Exploration 6.8%, Singleplayer 0.1%
- #34 Breeding Hospital
71% match3 user reviews67% of 3 reviews2025
Dev: びゅびゅ丸★
Windows
This is a hospital simulator for those aged 18 and over. You can have various experiences with multiple female nurses. The nurses will satisfy your sexual desires according to your choices. However, if you impregnate a girl, the nurse will bear all the responsibility.
Why similar: Medical Sim 80.5% ★, Turn-Based Strategy 15.7%, Choices Matter 3.7%, Singleplayer 0.2%
- #35 Alma
73% match4 user reviews100% of 4 reviews2021
Dev: Francesca PalamaraPub: Galaxy Cereal Studios LLC
Windows · Mac
Alma is an interactive narrative that captures the tension of work-life balance for healthcare workers. Play as Alma, a caring mother and pediatric nurse, who must tend to both aspects of her life. Alma is a story of self-care and the struggle to find balance in an imbalanced life.
Why similar: Medical Sim 52.6% ★, Education 25.2%, Interactive Fiction 15%, Hand-drawn 7.1%
- #36 Our Town
72% matchNo user reviews
Dev: Fish Truck Studios
Windows
Our Town is a 2.5D story-driven, horror investigation RPG set during a fictionalized 60's America. Deliver newspapers as you uncover secrets of the mundane. Through point-and-click investigations and visual-novel dialogue, discover the underbelly of this bustling town—if any.
Why similar: 2.5D 23.6%, Investigation 20.8%, RPG 18.3%, Mystery 15.5%, Hand-drawn 13.2%
- #37 Reanimation Inc.
72% matchVery Positive84% of 129 reviews2019
Dev: Dmitrii Lomakin
Windows
Reanimation inc is a completely realistic simulation - real urgent conditions and diseases, real protocols of care used in an ambulance, realistic simulation of the body! Do you like realistic games about medicine and simulators, games you need to think about? You 'll be happy!
Why similar: Medical Sim 100% ★
- #38 Do No Harm
69% matchMostly Positive74% of 873 reviews2025
Dev: Darts Games
Windows
Median: 2.5 hrsMean: 5.9 hrs≥1hr: 77%
Lovecraftian Doctor Simulator. Diagnose patients by analyzing unsettling symptoms and treat them using your Book of Medicine. Make moral choices — decide who to save or kill, discover whom to trust, and unlock multiple endings! Can you endure 30 days of perilous decisions?
Why similar: Medical Sim 61.9% ★, Investigation 19.6%, Mystery 10.4%, Choices Matter 5.8%, Story Rich 2.3%
- #39 Medic Simulator
71% matchNo user reviews
Dev: Eathrabaria
Windows
Become a doctor and treat patients in every area of medicine. Become a cardiologist, psychiatrist, dentist, dermatologist, oncologist, surgeon, ophthalmologist, neurologist…!
Why similar: Medical Sim 74.5% ★, Science 20.7% ★, Choices Matter 4.5%, Singleplayer 0.3%
- #40 Heart's Medicine - Hospital Heat
70% matchVery Positive96% of 364 reviews2017
Dev: Blue GiraffePub: GameHouse
Windows · Mac
Median: 5.1 hrsMean: 8.7 hrs≥1hr: 93%
The long awaited sequel to "Heart's Medicine - Time to Heal". An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring doctor at Little Creek Hospital!
Why similar: Medical Sim 98.8% ★, Story Rich 1.2%
- #41 Queen Naeja's Desires
69% match1 user reviews100% of 1 reviews2025
Dev: SongGame
Windows
Where your choices shape an epic narrative. Step into the shoes of Yafen, a soul betrayed by her own era and reborn as the queen consort to the bad-boy Prince Yonglie LieHong of Naer Kingdom.
Why similar: Medical Sim 59.3% ★, Interactive Fiction 14.9%, 2.5D 11.5%, RPG 8%, Exploration 6.3%
- #42 FORENSIC - M.E. Protocol
70% matchNo user reviews2026
Dev: k148 Game StudioPub: JanduSoft
Windows
Put on your gloves and enter the crime scene. In this investigation simulator, you will have to solve 9 unique and independent cases full of plot twists. Use drones, robots, and chemical analysis to discover what really happened. Here, you don't shoot the bad guys; you catch them with science.
Why similar: Medical Sim 57.4% ★, Interactive Fiction 21.4%, Investigation 9.8%, Exploration 7.3%, Mystery 4.1%
- #43 Human Constructor VR
71% match3 user reviews67% of 3 reviews2020
Dev: Exxit
Windows
Human Constructor VR is a virtual reality application designed for detailed study of the human structure and individual organs, bones, and muscles. This application contains only the anatomy of the male human body.
Why similar: Medical Sim 93.4% ★, Education 6.2%, Singleplayer 0.4%
- #44 Dr. Cares - Amy's Pet Clinic
70% matchMostly Positive79% of 75 reviews2018
Dev: NitrealPub: GameHouse
Windows · Mac
Get ready to test your vet skills in Dr. Cares - Amy's Pet Clinic!
Why similar: Medical Sim 100% ★
- #45 Life on the Edge
68% matchVery Positive91% of 95 reviews2022
Dev: LOTE Team
Windows · Mac
Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!
Why similar: Medical Sim 47.1% ★, Education 28.1%, Science 24.7% ★, Singleplayer 0.1%
- #46 Opawration!
69% matchNo user reviews
Dev: chinchingames
Windows
A 2D, veterinarian horror game. In this game, select the appropriate treatment and treat patients with topical products injections, surgeries. Treat patients over the course of 7 days, using the in-game computer to research the best treatment option. Playtime is 30 minutes.
Why similar: Medical Sim 85.6% ★, Hand-drawn 7.4%, Choices Matter 6.7%, Singleplayer 0.3%
- #47 MediSim: Emergency Response
68% matchNo user reviews
Dev: Mehmet Hilmi Değirmenci
Windows
As a young doctor, save lives in emergencies, advance from a health center to a major hospital, and manage your own facility. Perform first aid, and diagnostics, take on ambulance and helicopter missions, and build your medical team. A realistic medical simulation where every decision matters!
Why similar: Medical Sim 81% ★, Education 18.8%, Singleplayer 0.2%
- #48 Heart's Medicine - Time to Heal
68% matchVery Positive94% of 878 reviews2016
Dev: Blue GiraffePub: GameHouse
Windows · Mac
Median: 6.0 hrsMean: 12.1 hrs≥1hr: 92%
An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring surgeon at Little Creek Hospital!
Why similar: Medical Sim 98.2% ★, Story Rich 1.6%, Singleplayer 0.3%
- #49 Animal Rescue
67% matchNo user reviews
Dev: Spirit Games Studio
Windows
Animal Rescue is a unique game in which you play the role of a field rescuer-vet. Face the elements of nature and save innocent animals! Their life depends entirely on you! Someone has to save them! Will it be you?
Why similar: Medical Sim 65.8% ★, Education 27.2%, Exploration 7%, Singleplayer 0.1%
- #50 50 Minutes 'Til Impact
65% matchPositive93% of 28 reviews2025
Dev: Atomic Baby GamesPub: John Paul the Great Catholic University
Windows
50 Minutes 'Til Impact is set in a retro-futuristic world aboard an advanced, yet luxurious space train! It's a linear narrative adventure where players utilize 3D exploration, code solving, and visual novel interactions to do whatever they can to save everyone on board before time runs out.
Why similar: Investigation 32.9%, Interactive Fiction 32.7%, 2.5D 25.9%, Linear 8.1%, Singleplayer 0.4%
- #51 Accident
66% matchMostly Positive77% of 1,703 reviews2021
Dev: Duality Games
Windows
Median: 1.2 hrsMean: 2.4 hrs≥1hr: 56%
Become a journalist who researches old car accident cases. Help victims and perform first aid, obtain evidence and reconstruct the events to discover what really happened.
Why similar: Medical Sim 56.2% ★, Education 23.5%, Investigation 16.4%, Choices Matter 3.7%, Singleplayer 0.3%
- #52 Lifeguard Simulator
67% matchNo user reviews2026
Dev: FreeMind S.A.
Windows
Guard the beach, react fast, and save lives using quads, jet skis, motorboats, drones, and a helicopter. Patrol the bay, help those in need and uncover a hidden criminal intrigue beneath the waves.
Why similar: Medical Sim 62% ★, Education 26.5%, Exploration 5.9%, Choices Matter 5.2%, Singleplayer 0.4%
- #53 Flesh Blossom
67% matchNo user reviews
Dev: Crimson Pearl Games
Windows
You are Doctor Parsnip Green, the first and last line of defense against a grotesquely beautiful epidemic. Make difficult choices as you investigate the disease’s origin, operate on patients, and fight to save those you love - all while managing your own dwindling sanity.
Why similar: Medical Sim 45.1% ★, Interactive Fiction 13.6%, RPG 11.3%, Investigation 8.1%, Choices Matter 7.7%