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Games Like Substance Lab POL

60+ similar titles based on shared tags and player behavior. Themes include Education, Science, Casual, Singleplayer.

Substance Lab POL header art

Not fantasy alchemy—real chemistry. Combine substances with real reactions, solve quizzes on materials and equations, and play rhythm challenges in Substance Lab POL.

Reviews: No user reviews — 50%
Released: Coming soon
Developer: PhaseOutLimit
Genres: Casual, Indie
Platforms: Windows, Mac

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    97% matchNo user reviews2026
    Dev: Brainpowder
    Windows · Linux

    A minimalistic intuition trainer app designed to sharpen your intuitive senses and enhance your decision-making abilities.

    Why similar: Science 41.2%, Education 30.7%, Puzzle 7.2%, Casual 6.6%, Family Friendly 5.1%

  2. #2 Aggi's Tiny Friends
    96% match3 user reviews100% of 3 reviews2025
    Dev: Autumn SeniorPub: OST Senior
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    Join Aggi and dive into a world that lies just out of sight. Customize your own cell and see it thrive in a vibrant ecosystem. Discover a wide variety of organisms like you've never seen before. And learn real science in a playful and relaxed environment.

    Why similar: Science 50.5%, Education 26.4%, Casual 7.3%, Simulation 5.4%, Cute 3.9%

  3. #3 WaterMeasure
    96% matchNo user reviews
    Dev: Li Zheng
    Windows

    Given a 5-liter cup and a 3-liter cup, how measure 4 liters of water?

    Why similar: Science 41.8%, Education 23%, Casual 9.2%, Minimalist 8.6%, Crafting 8.5%

  4. #4 Chimp Memory
    95% matchPositive94% of 17 reviews2024
    Dev: Windmill's Light
    Windows

    Chimp Memory is a logical puzzle game and memory challenge. Take on the same tests faced by lab monkeys and prove your memory skills are sharper than theirs. Can you outperform the primates? Test yourself and find out!

    Why similar: Science 48.8%, Education 33.8%, Casual 7.4%, Simulation 6%, 2D 2.8%

  5. #5 MiTOSSis
    94% matchNo user reviews
    Dev: Allen Institute
    Windows

    A biology puzzle with real microscopy data

    Why similar: Science 56.5%, Education 29.1%, Puzzle 7.8%, Casual 6.1%, Singleplayer 0.5%

  6. #6 Electrical Leak
    94% matchNo user reviews
    Dev: Robut
    Windows

    Welcome to "Electrical Leak"—a electrician simulation and electrical puzzle game adapted from real-world cases! Armed with nothing but a test pen, you will face seemingly ordinary yet hazard-filled daily scenarios.

    Why similar: Science 46.6%, Education 30.4%, Simulation 9.2%, Puzzle 8.1%, Casual 3.1%

  7. #7 Breaking Good
    93% matchVery Positive88% of 162 reviews2017
    Dev: SeekSick6
    Windows · Mac · Linux
    Median: 3.1 hrsMean: 27.8 hrs≥1hr: 63%

    1 puzzle, 4 views. Grab your test tubes and enter the lab to solve a unique puzzle game based on chemical compounds. Match the chemical elements to get more than 900 different compounds and see how far you can go. Do you have what it takes?

    Why similar: Science 43.5%, Education 28%, Puzzle 6.6%, Minimalist 5.3%, Casual 5%

  8. #8 THE UNIVERSE
    92% match3 user reviews33% of 3 reviews2020
    Dev: Enrique Salvador
    Windows

    Feel like you are in space ! This application has been created in a photorealistic way, you will feel like you are on Mars, Jupiter, Mercury ... and ISS ! The best education game. If you like astronomy this is your application. You will feel that you are in space observing the entire universe.

    Why similar: Science 47.7%, Education 28.6%, Casual 14.4%, Simulation 8.6%, Singleplayer 0.7%

  9. #9 Ecocoru : Euclidean Constructions -- Compass & Ruler
    91% match4 user reviews100% of 4 reviews2022
    Dev: Sergey Krasnikov
    Windows

    Ecocoru is a puzzle game where you have to solve compass and ruler construction problems.

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  10. #10 Hydrogen Game
    91% match2 user reviews100% of 2 reviews2024
    Dev: kakeia
    Windows

    A falling puzzle game where you drop 118 different elements and aim for a high score. You don't have to know the elements! Can you see the 118th element?

    Why similar: Science 55%, Education 25.6%, Puzzle 8.6%, Casual 6%, Colorful 2.4%

  11. #11 Project Chemistry
    89% matchMostly Positive76% of 223 reviews2021
    Dev: Ata TürkoğluPub: Espale Studios
    Windows
    Median: 3.6 hrsMean: 25.7 hrs≥1hr: 88%

    Interact with elements and molecules in a way that you have never before! Observe them and make them react with each other in the sandbox mode. Synthesize every molecule in the quest mode. Discover countless macromolecules and the elegancy of chemistry.

    Why similar: Science 42.8%, Education 23.7%, Crafting 14.7%, Puzzle 6.8%, Simulation 3.6%

  12. #12 Osy Osmosis
    90% match4 user reviews75% of 4 reviews2017
    Dev: Cogent Education
    Windows · Mac · Linux

    Osy Osmosis is a fun game for all ages where you must help Osy stay safe as she navigates through her world collecting stars. To help Osy, you will use osmosis to keep her in balance with the world around her.

    Why similar: Science 55%, Education 33%, Casual 4%, Simulation 3.6%, Cute 3.3%

  13. #13 Virtual Chemistry Lab
    89% match2 user reviews100% of 2 reviews2023
    Dev: Alpay Akay
    Windows

    This is a serious game. Made for educational purposes. It was made in order to enable students to understand the high school chemistry curriculum and to provide equality of opportunity.

    Why similar: Science 43.3%, Education 33.5%, Crafting 12.4%, Simulation 7.8%, Relaxing 1.9%

  14. #14 Solitaire: Learn Chemistry
    88% match8 user reviews75% of 8 reviews2019
    Dev: RTWS
    Windows

    A combination of using flashcards for learning with the classic card game Solitaire.

    Why similar: Science 50.9%, Education 36.6%, Casual 12.5%

  15. #15 Nanoscape
    87% matchMixed60% of 20 reviews2021
    Dev: 3D Visualisation Aesthetics Lab
    Windows

    A first person exploration of a cancer cell deep in the human body, featuring a highly detailed simulation of cellular anatomy and processes based on the latest scientific research!

    Why similar: Science 48.9%, Education 31.6%, Casual 10.4%, Simulation 8.8%, Singleplayer 0.4%

  16. #16 NBody Gravitation
    86% match4 user reviews100% of 4 reviews2023
    Dev: Sean Frett
    Windows · Linux

    Place asteroids and planets and send them orbiting into targets in a physics-based puzzle game where everything attracts everything.

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  17. #17 Molecule - a chemical challenge
    86% matchMostly Positive71% of 28 reviews2018
    Dev: a.mighty.dish
    Windows

    Discover molecules and learn about science in this addictive Sokoban-style puzzle game!

    Why similar: Science 53.2%, Education 31.9%, Puzzle 10.1%, Indie 4.8%

  18. #18 Tyto Ecology
    85% matchMostly Positive76% of 437 reviews2016
    Dev: Immersed Games
    Windows · Mac

    Build your biome! With an empty biodome as your canvas, add plants and animals from three different ecosystems. Observe interactions like hunting, blooming, and even decomposing! Will your biodome last for decades, or will it experience a total ecosystem collapse? You’re in control!

    Why similar: Science 51.4%, Education 28.6%, Simulation 11.1%, Casual 6.3%, Indie 2.6%

  19. #19 Eureka! Superconductor Lab
    84% matchNo user reviews
    Dev: GomulGames
    Windows

    Eureka! Superconductor Lab is a crafting+simulation game where you synthesize materials and witness the astonishing scientific phenomena. Work alongside scholars, science geeks, and your girlfriend to synthesize the Holy Grail of modern physics: a room-temperature superconductor!

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  20. #20 Momentum Mayhem
    84% matchNo user reviews2024
    Dev: UnscriptedLogic
    Windows

    A casual 2.5D physics oriented game about building unorthodox contraptions to solve puzzles with a variety of items at disposal

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    83% matchMostly Positive75% of 305 reviews2017
    Dev: The Young Socratics
    Windows · Mac
    Median: 1.5 hrsMean: 9.2 hrs≥1hr: 62%

    Odyssey is an enchanting and innovative science adventure game. Help Kai and her family escape their captors on the Wretched Islands - and learn the history of astronomy, mechanics, and scientific reasoning as you read Kai's journal and solve puzzles along the way!

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    82% matchPositive95% of 22 reviews2021
    Dev: Eric Laflamme
    Windows

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    Dev: Creature LabsPub: Gameware Europe
    Windows

    This is a special world, inhabited by the amazing virtual life forms known as Norns. These cuddly little creatures have their own Digital DNA, brains and biochemistry. They learn and think for themselves but they need you to love them, care for them and play with them.

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  24. #24 Mądra Głowa
    82% matchNo user reviews2023
    Dev: LK Avalon
    Windows

    Mądra Głowa to kolekcja 27 multimedialnych gier i łamigłówek logicznych rozwijających umiejętność sprawnego myślenia i podejmowania decyzji. Jest przeznaczona dla dzieci w wieku 6-9 lat. Świeże i oryginalne pomysły gwarantują doskonałą zabawę i pełny rozwój potrzebnych zdolności.

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  25. #25 Laser Attraction
    81% matchVery Positive90% of 60 reviews2021
    Dev: Vectmatica
    Windows

    Play with lasers and solve puzzles in Laser Attraction. Use reflection, refraction, dispersion and filtration to direct the laser beams, mix and separate colours, open doors, hit targets and complete puzzles.

    Why similar: Science 45.7%, Education 16.8%, Puzzle 11.8%, Minimalist 6.8%, Simulation 6.1%

  26. #26 Force and Motion
    80% match3 user reviews100% of 3 reviews2024
    Dev: Nautilus Workshop
    Windows

    Force and Motion is a physics puzzle game where you apply your knowledge of real physics to solve puzzles in the game.

    Why similar: Science 44.7%, Education 27.9%, Puzzle 7.9%, Casual 6.8%, Simulation 6.1%

  27. #27 Marquito's Arcade - Play while Learning
    79% matchNo user reviews2024
    Dev: Megaillusion
    Windows

    Have fun and learn with this collection of educational games. Each one with different gameplays. Featuring: Cell Works - Chemibot Helps the City - Gaia and the Weather Powers - Super Pizza Delivery - Itchy Earth.More Games will Come!

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  28. #28 LX Patterns
    79% matchPositive84% of 31 reviews2021
    Dev: Thedox Games
    Windows · Linux

    How smart are you? The ability to recognize patterns is used to measure intelligence. LX patterns is a puzzle game in which you have to identify different patterns while listening to a relaxing soundtrack.

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  29. #29 Dustdrive: The Lightspeed Project
    77% matchNo user reviews
    Dev: Tavernpunk Games
    Windows · Mac · Linux

    A minimalist factory puzzle game about reaching the speed of light. Build an experimental engine that runs off galactic dust to accelerate your ship to impossible speeds. Match dust signatures carefully and manage your energy to avoid Rapid Unscheduled Disassembly!

    Why similar: Science 49.9%, Crafting 21.6%, Puzzle 11.6%, Simulation 5%, Minimalist 4.7%

  30. #30 Pythagoria
    78% matchMostly Positive75% of 258 reviews2016
    Dev: Vladimir Maslov
    Windows
    Median: 3.1 hrsMean: 215.9 hrs≥1hr: 80%

    Pythagoria is a brain-teasing number puzzle game.

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  31. #31 XPLORASI3D 2.0
    78% matchNo user reviews2022
    Dev: SYAHIR BAHIRAN BIN HILMIPub: MULTIPDPKIT
    Windows

    3D Digital Game-Based Learning.

    Why similar: Science 51.6%, Education 47.5%, Singleplayer 0.9%

  32. #32 Solarium
    77% matchMixed69% of 130 reviews2017
    Dev: Sunfleck Software
    Windows
    Median: 30 minMean: 8.9 hrs≥1hr: 36%

    Challenge yourself. What do you really know about plants? Want to find out? And win some points to build your own custom plants? Then welcome to Solarium!

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  33. #33 Crazy Plant Shop
    76% matchMostly Positive77% of 287 reviews2014
    Dev: Filament Classic
    Windows
    Median: 3.2 hrsMean: 5.3 hrs≥1hr: 94%

    In Crazy Plant Shop, players learn about genes and inheritance by breeding zany plants! Special requests from mysterious customers require players to understand dominant and recessive traits and how genetic traits get passed through generations. Use profits to acquire new breeds, purchase shop upgrades, and acquire new customers!

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  34. #34 Chemistry My Love
    75% matchNo user reviews
    Dev: SPIN Software
    Windows

    Chemistry My Love is the ultimate gamified educational tool for high school and college level chemistry. Balance chemical reaction coefficients, masses and concentrations, with step-by-step explanations. Level up your knowledge playing chemical games and solving computer-generated quizzes.

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  35. #35 11111Game
    76% match2 user reviews50% of 2 reviews2022
    Dev: HexyArts
    Windows · Mac

    Master addition in different bases. Slide tiles to add them, take advantage of overflow mechanic and game's grid.

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  36. #36 Cellka
    75% match4 user reviews100% of 4 reviews2024
    Dev: Kcorbco
    Windows

    Cellka is a cute little merger game based around the cells of the human body! Merge cells together to try and get the high score before the entire body fills up!

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    74% match4 user reviews100% of 4 reviews2025
    Dev: Mukai Systems
    Windows · Mac

    Infinite Einstein Tiles is a casual puzzle game themed around an aperiodic monotile discovered by David Smith in 2022. Once you've solved all the puzzles, you might understand how aperiodic tiling with a single tile is achieved.

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  38. #38 Chemist Wanted
    74% matchNo user reviews
    Dev: SciViewLearn
    Windows

    “Chemist Wanted” is a crafting game with a difference. In this lab simulator, you use real chemistry to create specific compounds. Set up your equipment, run the experiment and create your products. The higher the purity, the more money you will earn!

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    73% matchVery Positive93% of 712 reviews2014
    Dev: Alan HazeldenPub: Draknek & Friends
    Windows · Mac
    Median: 1.5 hrsMean: 4.2 hrs≥1hr: 57%

    Sokobond is an elegantly designed puzzle game about chemistry. It's logical, minimalist, and beautiful - crafted with love and science.

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    73% match5 user reviews40% of 5 reviews2024
    Dev: shrubec
    Windows · Linux

    TerraBlocks is a geography-based puzzle game where you move and rotate drifting continent pieces from the North Pole to their correct places. As you progress, the challenge increases. Test your spatial awareness and geographic knowledge while rebuilding the world!

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  41. #41 Pinball Chemist
    73% matchNo user reviews2026
    Dev: NotebookGames
    Windows

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  42. #42 Size Matters
    71% matchVery Positive87% of 514 reviews2021
    Dev: Mazen GamesPub: GrabTheGames
    Windows
    Median: 2.0 hrsMean: 2.8 hrs≥1hr: 69%

    You play as a scientist who is shrinking every second in a race against time! Find all the ingredients and formulas scattered around the laboratory, which are necessary for producing the life-saving antidote. But beware, your time is very precious.

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    72% match7 user reviews86% of 7 reviews2021
    Dev: Syahir Bahiran HilmiPub: MULTIPDPKIT
    Windows

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    71% matchNo user reviews2026
    Dev: Tim Burykin
    Windows

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    68% matchOverwhelmingly Positive95% of 1,085 reviews2025
    Dev: R74n
    Windows · Mac
    Median: 1.8 hrsMean: 3.8 hrs≥1hr: 61%

    Falling-sand sandbox game with 500+ elements, chemistry, fire, life, food, and anything you can imagine.

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  46. #46 Chemistower
    69% matchPositive100% of 16 reviews2026
    Dev: WunoumenalPub: Wunoumenal Studio
    Windows

    Create explosions, acids, bases and more in this chemistry inspired tower defense game! Purchase atoms to fight through waves of antimatter enemies and learn about chemistry along the way.

    Why similar: Science 51.3%, Education 29.3%, Crafting 6.9%, Minimalist 5.3%, Colorful 3.6%

  47. #47 HoloLAB Champions
    72% matchPositive88% of 24 reviews2018
    Dev: Schell Games
    Windows

    Grab your safety goggles and set out on a chemical-burning, liquid-stirring, camera-whirring competition in HoloLAB Champions, a virtual reality chemistry game show.

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    71% match1 user reviews0% of 1 reviews2023
    Dev: SRM Games
    Windows

    A family friendly casual game that teaches children about celestial bodies. Learn about the Sun, Earth, Jupiter, and the other celestial bodies that make up our Solar System. You or your child will also be able to create your own Solar System in a sleek and in-depth fashion!

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  49. #49 Overlab
    69% match1 user reviews0% of 1 reviews2026
    Dev: SIM games
    Windows

    Combine atoms to create molecules and fulfill orders to survive as long as possible.

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  50. #50 Compound Interest
    70% matchNo user reviews
    Dev: GhostRZZRPub: coldboot.studio
    Windows

    Build your atomic empire. Fuse elements, craft real compounds, trigger chain reactions, and break the periodic table wide open in an idle game where chemistry IS the strategy.

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  51. #51 Against the Gradient
    70% match3 user reviews100% of 3 reviews2017
    Dev: Cogent Education
    Windows · Mac · Linux

    A microscopic world is in need of your help! Add transporters to membranes to move molecules and ions into and out of cells. Your goal is to reach specific concentrations.

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    70% matchNo user reviews2023
    Dev: CracleSnap
    Windows

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    69% match1 user reviews0% of 1 reviews2023
    Dev: LK Avalon
    Windows

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    66% matchPositive91% of 33 reviews2025
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    Windows · Mac

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  55. #55 ATCo2
    68% match3 user reviews100% of 3 reviews2023
    Dev: Rabbit Garden Software
    Windows · Mac · Linux

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  56. #56 Atomcraft
    64% matchVery Positive96% of 247 reviews2026
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    65% matchVery Positive99% of 82 reviews2024
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    67% matchPositive81% of 16 reviews2022
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    Windows

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    66% matchMostly Positive76% of 667 reviews2020
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    Median: 4.4 hrsMean: 5.9 hrs≥1hr: 93%

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    68% match8 user reviews88% of 8 reviews2017
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