- #1 Turbulence - Airplane Survival Simulator
96% matchNo user reviews
Dev: True GamesPub: Idea Labs
Windows
When your airplane enters a massive storm, you aren’t a passenger anymore. You are a survivor. Trapped at 35,000 feet, you need to keep a cool head and act fast to live through the crisis. Can you make it to a happy landing?
Why similar: Medical Sim 41% ★, Outbreak Sim 39.5% ★, Flight 12.7%, Simulation 6.4%, Singleplayer 0.3%
- #2 Life on the Edge
96% matchVery Positive90% of 98 reviews2022
Dev: LOTE Team
Windows · Mac
Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!
Why similar: Medical Sim 33.7% ★, Outbreak Sim 26.9% ★, Science 26.8%, Simulation 5%, Tactical 4.5%
- #3 Propa.
95% matchMostly Positive75% of 16 reviews2025
Dev: Contagio GamesPub: Mutation Works
Windows
In this RTS game, control your virus to replicate and evolve against a powerful immune system. Equip gene segments to create unique viral armies. Use tactics to eliminate immune cells or achieve escape. Develop strategies for domination and enjoy endless strategic fun!
Why similar: Medical Sim 36.8% ★, Outbreak Sim 32.1% ★, Wargame 10.7%, Science 8.7%, RTS 7.1%
- #4 Ministry of Pandemic
94% match5 user reviews60% of 5 reviews2022
Dev: Ceyhan KapusuzPub: Cookie Mechanics
Windows
Ministry of Pandemic is a strategy and simulation game that forces social and economic balance during the pandemic. Formulate your strategy for survival while keeping all aspects of society steady.
Why similar: Medical Sim 37% ★, Outbreak Sim 33.3% ★, Real Time Tactics 13.4%, Science 12.7%, Simulation 2.9%
- #5 Bio Inc. Redemption
94% matchVery Positive87% of 3,086 reviews2018
Dev: DryGin Studios
Windows
Median: 2.4 hrsMean: 5.9 hrs≥1hr: 73%
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
Why similar: Medical Sim 49.6% ★, Outbreak Sim 40.5% ★, RTS 5.3%, Simulation 3.3%, Singleplayer 0.7%
- #6 Plane Accident: Prologue
93% matchMostly Positive70% of 50 reviews2024
Dev: White Pig GamesPub: Duality Games
Windows
Dive into the heart of aviation mysteries in "Plane Accident: Prologue." Explore realistic crash sites, analyze evidence, and solve puzzles. Unveil the truth in this thrilling prelude to the full "Plane Accident" experience.
Why similar: Outbreak Sim 53.7% ★, Flight 23.7%, Science 18.6%, Simulation 3.7%, Singleplayer 0.3%
- #7 Rescue Operations Simulator
92% matchNo user reviews
Dev: Monuments Games
Windows
Rescue Operations Simulator is a game where you play the role of USAR (Urban Search and Rescue) member and a team leader. You will arrange and execute rescue operations from real life catastrophic events that shocked and changed the whole world.
Why similar: Medical Sim 44% ★, Outbreak Sim 42.9% ★, Simulation 4.6%, 3D 2.8%, Realistic 2.8%
- #8 中国战疫
91% matchMostly Positive76% of 70 reviews2022
Dev: 不吃蛋黄
Windows
《中国战疫》是一款科普防疫知识的模拟经营类游戏,玩家将临危受命地前往不同地区进行疫情控制,展示中国防疫的成功经验,最终达成疫情控制和经济稳定的双赢。
Why similar: Medical Sim 45.3% ★, Outbreak Sim 42.4% ★, RTS 6.2%, Simulation 3.5%, 3D 2.3%
- #9 Pandemic Crisis
91% match9 user reviews100% of 9 reviews2020
Dev: Thor Gaming
Windows
In the event of a global pandemic, would your first priority be preserving lives or saving the economy?
Why similar: Outbreak Sim 48.7% ★, Medical Sim 44.2% ★, Simulation 4.5%, Realistic 1%, Singleplayer 0.8%
- #10 Medic Simulator
90% matchNo user reviews
Dev: Eathrabaria
Windows
Become a doctor and treat patients in every area of medicine. Become a cardiologist, psychiatrist, dentist, dermatologist, oncologist, surgeon, ophthalmologist, neurologist…!
Why similar: Medical Sim 60.9% ★, Science 25.6%, Simulation 8.7%, 3D 4.2%, Singleplayer 0.6%
- #11 The Crawling Dead
89% matchPositive85% of 13 reviews2025
Dev: Quinton Van Lom
Windows
Design, deploy, and manage the release of parasitic wasps to save a national park from invasive insect pests. Harness the power of nature’s most efficient killers to strike back at the invaders and turn them into The Crawling Dead!
Why similar: Outbreak Sim 54% ★, Real Time Tactics 19.2%, Science 18.1%, RTS 5.3%, Simulation 3.1%
- #12 Pestis
89% matchMostly Positive70% of 109 reviews2018
Dev: DIEDEMOR STUDIO GAMESPub: Laush Studio
Windows
Median: 12 minMean: 3.0 hrs≥1hr: 32%
A young Plague Doctor, only to learn that the Academy sent to a small village, which, like the whole country is gripped by plague
Why similar: Medical Sim 41.2% ★, Outbreak Sim 38.1% ★, Science 18.3%, Simulation 2.4%
- #13 NEURAL NETWORK
88% matchNo user reviews2026
Dev: Troshkin AndreiPub: HERRTROST GAMES
Windows · Linux
NEURAL NETWORK is a unique blend of strategy and frighteningly realistic simulation. Your artificial intelligence has just been launched and connected to the global network - now you must manage and control it! Will your AI save the world or destroy humanity?
Why similar: Outbreak Sim 48.7% ★, Wargame 22.8%, Real Time Tactics 18.4%, RTS 5.1%, Simulation 2.9%
- #14 Operation Pill
87% matchPositive91% of 11 reviews2022
Dev: xr407
Windows
Operation Pill is the story of a small and brave pill that gets into your body and saves it from pathogenic bacteria. Arm yourself with an electrostatic shield and a germicidal cannon and save your body!
Why similar: Medical Sim 59.1% ★, Science 17.7%, Flight 14.1%, 3D 3.8%, Simulation 2.5%
- #15 GastroRun
86% matchMostly Positive77% of 13 reviews2024
Dev: Nuatgames
Windows
Gastro Run is a fast-paced educational adventure game full of obstacles, boss fights, races, withlessons placed throughout the game. You play as Gastro, a witty nano-bot whose goal is to help patients with enzyme deficiency break down food as it travels through the digestive system.
Why similar: Medical Sim 56.6% ★, Flight 26.9%, Third Person 6.4%, 3D 3.8%, Action 3.2%
- #16 Morbus: The Burden Of The Apothecary
85% matchNo user reviews
Dev: Viktor PekarPub: Introverse Interactive
Windows · Linux
A top-down plague simulation RPG set in a living medieval tapestry. Play the last apothecary in a dying town treating the sick, containing the outbreak, and navigating the politics of factions who'd sooner see you burn.
Why similar: Medical Sim 59.9% ★, Outbreak Sim 35.9% ★, Simulation 3.5%, Singleplayer 0.6%
- #17 Medical verdict
84% matchMixed57% of 53 reviews2018
Dev: Volokitin Andrey
Windows
Here is a fun simulator of passing a medical examination in the Chelyabinsk clinic with realistic graphics and interesting gameplay! Take the coronavirus test! Collect as many virtual health points as you can, but remember ... this is just a game!
Why similar: Medical Sim 87.8% ★, Simulation 7.8%, Realistic 2.8%, Indie 1.5%
- #18 英雄荣光医院
82% match1 user reviews100% of 1 reviews2026
Dev: Areas RPub: PeopleFirstAI
Windows
“Hero Hospital” is a classic hospital management game: send in undercover agents and fake patient brokers, unleash dogs to cause crashes and chaos, dump trash and throw bombs, and even head into outbreak zones to fight viruses. The gameplay can be expanded endlessly.
Why similar: Medical Sim 53% ★, Outbreak Sim 44.3% ★, Simulation 2.7%
- #19 ZombieWave-UnlimitedChallenges
83% match6 user reviews67% of 6 reviews2021
Dev: AlloyStove
Windows
This is a game to lead soldiers against zombies.You can lead soldiers to complete challenges without limit.
Why similar: Outbreak Sim 41.6% ★, Wargame 23.7%, Real Time Tactics 18.5%, Shooter 7.2%, 3D 3%
- #20 Gelluloid Domination
80% matchPositive87% of 15 reviews2025
Dev: Tractor Set GO!
Windows
Gelluloid Domination is a fast-paced, strategic and tactical game where you grow a network of cells. Expand by assimilating nearby cells, fight off pathogens and develop nanoboosts in the lab. Other cells want to propagate their DNA too, so this won't be easy. Can your cells achieve domination?
Why similar: Medical Sim 36.8% ★, Science 21.4%, Real Time Tactics 16.2%, Tactical 7.9%, RTS 6.6%
- #21 Defi's Devotion
81% matchNo user reviews2026
Dev: Sean PearsonPub: Mythberry Studio
Windows
Become the plague in an asymmetrical player verses simulation battle for immortality. Infect populations, collapse economies, and harvest the dead to fuel your path to lichhood; only if you can conquer an adaptive world fighting to survive.
Why similar: Outbreak Sim 58.7% ★, Real Time Tactics 22.6%, Third Person 8.2%, Simulation 4.9%, RTS 4.3%
- #22 Surgeon Simulator VR: Meet The Medic
81% matchMostly Positive76% of 586 reviews2016
Dev: Bossa Studios
Windows
Median: 18 minMean: 1.7 hrs≥1hr: 14%
Surgeon Simulator VR: Meet the Medic – be the Medic and operate on the Heavy in this free and exclusive teaser for the HTC Vive!
Why similar: Medical Sim 92.1% ★, Simulation 5.1%, Action 2.1%, Indie 0.7%
- #23 Symptoms of Infection
79% matchNo user reviews
Dev: ORB Research & Broadcasting
Windows · Linux
Examine and test patients for common and novel infections using sophisticated medical instrumentation and disinfection procedures. All infected patients must be sent to the isolation ward for further evaluation or treatment. Rumors of mysterious diseases and human experimentation are unconfirmed.
Why similar: Outbreak Sim 58.7% ★, Medical Sim 33.5% ★, Simulation 6.5%, Singleplayer 1.3%
- #24 Sticks and Stones
79% matchNo user reviews2027
Dev: DiveDev
Windows
Post-apocalyptic survival simulator set after an asteroid (or asteroids) impact.
Why similar: Medical Sim 37.9% ★, Outbreak Sim 35.3% ★, Science 17.5%, Simulation 3.7%, Realistic 2.9%
- #25 Wrist Catcher-寸关
78% match3 user reviews0% of 3 reviews2025
Dev: 昆吾灌灌KWGG
Windows
You are an apprentice of a traditional Chinese medicine herbalist in South Village. Your task is deceptively simple: Examine the pulse, ask about the symptoms and verify the identity of villagers and outsiders to expose the hidden "false people" from the diagnostic details.
Why similar: Medical Sim 49% ★, Outbreak Sim 47.8% ★, Simulation 1.5%, Linear 1.4%, Singleplayer 0.1%
- #26 They Are Rising
77% matchNo user reviews2026
Dev: zj
Windows
They Are Rising is an RTS strategy game set against the backdrop of the apocalypse. Combine skills, build a massive army, establish shelters, and fight against large numbers of enemies. How long can you survive?
Why similar: Outbreak Sim 44.7% ★, Wargame 21.1%, Real Time Tactics 16.7%, RTS 6.8%, Shooter 6.7%
- #27 Helicopter Gunship DEX
77% matchVery Positive87% of 200 reviews2022
Dev: Jimmy Arcade Limited
Windows
Helicopter Gunship DEX aims to replicate the brilliance of 90s helicopter simulators using modern technology. Employ realistic helicopter tactics during missions generated by a sophisticated procedural random mission system giving you an almost unlimited amount of re-playability.
Why similar: Flight 32.4%, Wargame 29.9%, Tactical 8.4%, Third Person 7.1%, Simulation 6.1%
- #28 Reanimation Inc.
78% matchVery Positive84% of 130 reviews2019
Dev: Dmitrii Lomakin
Windows
Reanimation inc is a completely realistic simulation - real urgent conditions and diseases, real protocols of care used in an ambulance, realistic simulation of the body! Do you like realistic games about medicine and simulators, games you need to think about? You 'll be happy!
Why similar: Medical Sim 90.2% ★, Simulation 8.3%, Indie 1.5%
- #29 Fire Rescue Squad
76% matchNo user reviews
Dev: NPC GamesPub: Creative Forge
Windows
Fire Rescue Squad. An action game, a simulator from a first-person perspective, in which the player participates in firefighting actions, divided into several missions.
Why similar: Medical Sim 42.6% ★, Outbreak Sim 40% ★, Third Person 5.3%, Simulation 4%, 3D 3%
- #30 Supermarket Maker
75% matchNo user reviews
Dev: El NanPub: La Blen
Windows
Build and manage your very own Supermarket and make it success, with good offers and best selected products. Attract more customers with an aggressive strategy and grow to become the best Supermarket in town.
Why similar: Medical Sim 49.7% ★, Outbreak Sim 38.9% ★, Simulation 7.9%, 3D 2.8%, Indie 0.4%
- #31 Plane Accident
74% matchMixed55% of 290 reviews2024
Dev: White Pig GamesPub: Duality Games
Windows
Become an inspector examining causes of plane crashes. Visit the crash site, gather evidence and interrogate witnesses. Explain whether the accident was caused by independent factors or human errors.
Why similar: Outbreak Sim 58.3% ★, Flight 22.7%, Simulation 10%, 3D 4.9%, Linear 2.8%
- #32 40 Days [四十天]
76% matchMixed50% of 12 reviews2017
Dev: Black Phoenix Studio
Windows · Mac
40 Days is a special strategy simulation game related to infectious diseases spread all over the city. You, as ahead of the quarantine department, have been given full authority and manpower to contain the city, deal with different parties, virus in the city and most importantly find out the cure.
Why similar: Outbreak Sim 93.3% ★, Simulation 5.6%, Indie 1.1%
- #33 Trojan Inc.
75% matchMostly Negative36% of 33 reviews2017
Dev: WalkBoy Studio
Windows
Will you be able to infect all devices of the world? «Trojan Inc.» - simulator, which will involve you in a world of computer viruses and trojans.
Why similar: Outbreak Sim 92.4% ★, Simulation 6.3%, Indie 1.2%
- #34 CURE - A Hospital Simulator
71% matchVery Positive89% of 730 reviews2025
Dev: Sentinel Games
Windows
Median: 4.6 hrsMean: 8.1 hrs≥1hr: 84%
Manage the night shift of an ER during the apocalypse, solo or with friends online: Diagnose patients. Design and grow your hospital, and defend against the undead while treating the living. If you're a creator, connect the game to Twitch and make the audience your patients for even more fun!
Why similar: Medical Sim 44.4% ★, Outbreak Sim 39.3% ★, Shooter 6.8%, Realistic 3.2%, Simulation 3.2%
- #35 Dr. Cares - Amy's Pet Clinic
74% matchMostly Positive79% of 76 reviews2018
Dev: NitrealPub: GameHouse
Windows · Mac
Get ready to test your vet skills in Dr. Cares - Amy's Pet Clinic!
Why similar: Medical Sim 90.4% ★, Simulation 9.6%
- #36 Vaccine Delivery Adventure
73% matchMostly Positive73% of 15 reviews2022
Dev: The VALIDATE Network
Windows
Vaccine Delivery Adventure is a classic side-scrolling action game where a healthcare worker has to overcome the challenges of delivering the BCG Vaccine to the communities that need it!
Why similar: Medical Sim 72.8% ★, Science 19.4%, 3D 3.6%, Action 3.6%, Singleplayer 0.6%
- #37 Bacterium / 生命之旅
73% matchPositive84% of 49 reviews2018
Dev: Dragon Whisper GamePub: Zodiac Interactive
Windows
In the coming decades, a huge breakthrough in nano-medical technology will bring a new light to cure terminally ill patients. As a nano-robot operator, you will be involved in a battle between nanobots and diseases!
Why similar: Medical Sim 85.2% ★, Simulation 8.3%, Action 4.9%, Indie 1.6%
- #38 The Book of Plagues
70% matchPositive88% of 26 reviews2026
Dev: DiaMMax Games
Windows
The city is drowning in Plague. Panic, hunger, and fear are tearing it apart. You are the last one who can change its fate: heal it, hold it back from collapse… or drive it to ruin with your own hands!
Why similar: Medical Sim 51.8% ★, Outbreak Sim 45.6% ★, Simulation 2.6%
- #39 Dr Greenstuff
73% matchVery Positive87% of 148 reviews2018
Dev: Black DiskettePub: Black Diskette Studio
Windows
Discover the life of Dr Greenstuff, grow marijuana, coca, make meth', drugs and more to keep your legal/illegal business running.
Why similar: Medical Sim 89.1% ★, Simulation 9.2%, Indie 1.8%
- #40 Heart's Medicine - Hospital Heat
72% matchVery Positive96% of 366 reviews2017
Dev: Blue GiraffePub: GameHouse
Windows · Mac
Median: 5.1 hrsMean: 8.7 hrs≥1hr: 93%
The long awaited sequel to "Heart's Medicine - Time to Heal". An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring doctor at Little Creek Hospital!
Why similar: Medical Sim 90.5% ★, Simulation 8%, Indie 1.5%
- #41 Emergency Room Simulator
71% matchNo user reviews
Dev: Caipirinha GamesPub: Aerosoft
Windows
In Emergency Room Simulator, you become a dedicated doctor in the emergency room, responsible for diagnosing and treating patients as well as saving lives. This professional simulation offers an immersive experience of working in a fast-paced medical environment.
Why similar: Medical Sim 73.5% ★, Simulation 9.9%, Third Person 6.8%, 3D 5.1%, Realistic 4.1%
- #42 Hell Of War: Combined Arms
70% matchNo user reviews
Dev: Ravens Row
Windows
Hell Of War is a tactical FPS/RTS hybrid where you command the battlefield as a combat drone operator and can instantly take control of any unit — from infantry commanders to tanks and FPV drones. Plan from above, coordinate forces in real time, and intervene personally. Every decision has a cost.
Why similar: Wargame 29%, Real Time Tactics 22.5%, Flight 12.1%, RTS 9%, Tactical 8.7%
- #43 Infect and Destroy
71% matchMostly Negative36% of 58 reviews2015
Dev: FarrugiaSoft
Windows · Linux
Play as the zombies! Infect and Destroy is an indie game in which you play as an infectious disease with the sole purpose of eliminating everyone on Earth. Play as an ultra-intelligent self-aware virus capable of reanimating the dead and turning them into your minions.
Why similar: Outbreak Sim 90.1% ★, Simulation 5.5%, Action 3.3%, Indie 1.1%
- #44 3D PUZZLE - Farm House
70% matchMixed44% of 43 reviews2022
Dev: AztechPub: Azerbaijan Technology
Windows · Mac · Linux
Collect a 3D puzzle, transferring things to the right places to create a beautiful house.
Why similar: Medical Sim 49.9% ★, Outbreak Sim 44.5% ★, 3D Platformer 2.9%, 3D 2.7%
- #45 Total City Defence
69% matchNo user reviews2025
Dev: Imprint Gaming
Windows
Total City Defense is a zombie themed survival game where you must complete each level to progress. Using the mouse and keyboard you control various units, including Troops, Turrets and Drones to make your way through each level rescuing civilians, VIPS and destroying enemy strong holds.
Why similar: Outbreak Sim 58.2% ★, Wargame 27.1%, Tactical 5.6%, Sci-fi 3.7%, Action 3%
- #46 TakeDogs
69% matchNo user reviews
Dev: Kelyen GamesPub: Kelyen
Windows
TakeDogs is a realistic modern warfare FPS where you will join a special operations group, fight on real maps at 1:1 scale simulating authentic ballistic physics, learn to pilot real aircraft and travel to conflict zones to dismantle terrorist organizations or high-value targets.
Why similar: Medical Sim 49.7% ★, Wargame 21.5%, Real Time Tactics 18.4%, Shooter 7.3%, 3D 3.1%
- #47 Kamikaze Strike: FPV Drone
67% matchPositive84% of 44 reviews2025
Dev: Dinomore Games
Windows
Fly a kamikaze drone through fast-paced FPV missions. Dodge bullets, sneak past jammers and radars, and crash into tanks, troops, and enemy bases. Discover diffferent drones and face tougher challenges in every level.
Why similar: Flight 30%, Wargame 29.5%, Tactical 11%, Third Person 7.6%, Simulation 5.6%
- #48 S4Game
68% matchNo user reviews
Dev: Viral Studios
Windows
S4Game aims to provide health professionals with an innovative approach to acquire soft skills to foster their professional development. Their main learning objective is the acquisition of soft skills required during work in an operating room, such as communication or teamwork.
Why similar: Medical Sim 83.4% ★, Third Person 6.7%, 3D Platformer 3.2%, Simulation 2.9%, 3D 2.8%
- #49 Enemy Engaged: Apache vs Havoc
67% match6 user reviews50% of 6 reviews2025
Dev: RazorworksPub: Strategy First
Windows
East meets West in an apocalyptic clash of the superpowers as the US Apache Longbow and the Russian Havoc go head to head. Easily accessible yet deeply challenging gameplay, an intense and absorbing atmosphere and super- fast speeds make the Apache Havoc an amazing flying experience.
Why similar: Flight 25.6%, Wargame 22.7%, Real Time Tactics 18%, Shooter 13.4%, Simulation 10%
- #50 Human Constructor VR
69% match3 user reviews67% of 3 reviews2020
Dev: Exxit
Windows
Human Constructor VR is a virtual reality application designed for detailed study of the human structure and individual organs, bones, and muscles. This application contains only the anatomy of the male human body.
Why similar: Medical Sim 87.7% ★, Simulation 5.8%, Realistic 5.4%, Singleplayer 1.1%
- #51 Medic: Pacific War – Prologue
67% matchNo user reviews
Dev: Hypnotic Ants
Windows
Become a Medic - a true war hero. Survive the horror of the Pacific Front where bombs fall from the sky and rifle bullets cut the air. You are the last hope of your wounded companions. Your decisions will change the course of the battle, but not all of them will be easy to make!
Why similar: Medical Sim 63.2% ★, Shooter 10.8%, Tactical 7%, Simulation 5.8%, 3D 4.5%
- #52 Evil Labs
68% matchMixed70% of 82 reviews2018
Dev: Mirabolis Studios
Windows
Median: 4.3 hrsMean: 5.6 hrs≥1hr: 96%
Evil Labs is a game about building and managing your own Evil Laboratory. Research and develop diseases, infect people, sell the cure and get rich!
Why similar: Outbreak Sim 91.1% ★, Simulation 6.9%, Indie 1.3%, Singleplayer 0.7%
- #53 Quarantine
67% matchMixed60% of 437 reviews2017
Dev: SproingPub: 505 Games
Windows
Median: 48 minMean: 3.2 hrs≥1hr: 40%
Quarantine is an intense turn-based strategy game about waging war on pandemic disease. Recruit a team of specialized operatives to deploy on worldwide missions. Research the contagion, upgrade your tech, and quarantine the outbreak before it kills us all.
Why similar: Outbreak Sim 85.5% ★, Tactical 8.7%, Simulation 5.3%, Indie 0.6%
- #54 Bye Bye Swingby
66% match3 user reviews100% of 3 reviews2023
Dev: YYGames
Windows
'Bye Bye Swingby' is a fresh and unique simulation game that tells a sad story of escaping a destroyed Earth and exploring a new world. Take a rocket into space and use the gravity of the stars to travel to new worlds in Swingby.
Why similar: Flight 24.1%, Wargame 23.5%, Science 19.4%, Shooter 9.5%, Third Person 6.7%