- #1 Bio Inc. Redemption
97% matchVery Positive87% of 3,146 reviews2018
Dev: DryGin Studios
Windows
Median: 2.4 hrsMean: 5.9 hrs≥1hr: 72%
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
Why similar: Medical Sim 38.5% ★, Outbreak Sim 31.1% ★, RTS 13.3%, Education 7.9%, Strategy 5.1%
- #2 Germ Swarm: Evolution & Mutation
96% matchNo user reviews
Dev: Interlink Game Studio
Windows · Mac
Fight waves of ever-mutating bacteria and viruses in an immune system roguelite. Evolve your immune system, unlock medical interventions, and build unique synergies to survive.
Why similar: Medical Sim 35.3% ★, Outbreak Sim 34.8% ★, RTS 10%, Physics 7.3%, Science 5.8%
- #3 Nano Fighter Anti Disease
96% match9 user reviews89% of 9 reviews2021
Dev: LBR games
Windows
Nano Fighter Anti Disease is a flight action game. Controlling a nanoscale fighter, flies over the acid sea of digestive system, passes through the scarred inflammatory lesions, launch a fierce attack towards various pathogens with medicine ammos and biological missiles.
Why similar: Medical Sim 36.7% ★, Outbreak Sim 32.2% ★, Wargame 10.7%, Science 8.7%, RTS 7.1%
- #4 Life on the Edge
94% matchVery Positive90% of 98 reviews2022
Dev: LOTE Team
Windows · Mac
Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!
Why similar: Medical Sim 31.1% ★, Outbreak Sim 24.6% ★, Science 13.8%, Education 12.9%, Strategy 7.8%
- #5 Gelluloid Domination
94% matchPositive87% of 15 reviews2025
Dev: Tractor Set GO!
Windows
Gelluloid Domination is a fast-paced, strategic and tactical game where you grow a network of cells. Expand by assimilating nearby cells, fight off pathogens and develop nanoboosts in the lab. Other cells want to propagate their DNA too, so this won't be easy. Can your cells achieve domination?
Why similar: Medical Sim 29.4% ★, RTS 17.1%, Abstract 10.8%, Minimalist 10.2%, Science 9.5%
- #6 中国战疫
93% matchMostly Positive75% of 71 reviews2022
Dev: 不吃蛋黄
Windows
《中国战疫》是一款科普防疫知识的模拟经营类游戏,玩家将临危受命地前往不同地区进行疫情控制,展示中国防疫的成功经验,最终达成疫情控制和经济稳定的双赢。
Why similar: Medical Sim 40% ★, Outbreak Sim 37% ★, RTS 17.7%, Strategy 4.5%, Simulation 0.6%
- #7 战地细胞(Battlefield Cell)
92% match6 user reviews100% of 6 reviews2022
Dev: E-Cell
Windows
During the pandemic, would you be curious about how our bodies react to the virus? Are you wondering: "What' is autoimmunity?" "All definitions and thesis of the immunology are too hard to understand!" Don't be afraid! After beating the game, you get all the necessary information and fun!
Why similar: Outbreak Sim 39.1% ★, RTS 24.4%, Education 15%, Science 13.4%, Strategy 6%
- #8 Turbulence - Airplane Survival Simulator
91% matchNo user reviews
Dev: True GamesPub: Idea Labs
Windows
When your airplane enters a massive storm, you aren’t a passenger anymore. You are a survivor. Trapped at 35,000 feet, you need to keep a cool head and act fast to live through the crisis. Can you make it to a happy landing?
Why similar: Medical Sim 42.4% ★, Outbreak Sim 40.4% ★, Nonlinear 8.9%, Physics 6.9%, Simulation 1.2%
- #9 112 Operator
91% matchVery Positive89% of 7,278 reviews2020
Dev: Jutsu GamesPub: Games Operators
Windows · Mac
Median: 3.3 hrsMean: 11.8 hrs≥1hr: 86%
Manage emergency services in any city in the world! Take calls and dispatch rescue forces. Handle difficult situations, now depending on the weather, and traffic. Help the citizens through cataclysms and natural disasters, becoming a better emergency number operator every day!
Why similar: Moddable 28.9%, Medical Sim 28.7% ★, RTS 15.2%, Education 8.9%, Minimalist 8.7%
- #10 Pestis
90% matchMostly Positive70% of 109 reviews2018
Dev: DIEDEMOR STUDIO GAMESPub: Laush Studio
Windows
Median: 12 minMean: 3.0 hrs≥1hr: 32%
A young Plague Doctor, only to learn that the Academy sent to a small village, which, like the whole country is gripped by plague
Why similar: Medical Sim 37.3% ★, Outbreak Sim 34.2% ★, Education 11.7%, Science 9.3%, Logic 6.6%
- #11 Morbus: The Burden Of The Apothecary
89% matchNo user reviews
Dev: Viktor PekarPub: Introverse Interactive
Windows · Linux
A top-down plague simulation RPG set in a living medieval tapestry. Play the last apothecary in a dying town treating the sick, containing the outbreak, and navigating the politics of factions who'd sooner see you burn.
Why similar: Medical Sim 53.1% ★, Outbreak Sim 31.5% ★, Abstract 14.5%, Simulation 0.6%, Singleplayer 0.3%
- #12 Minesweeper Sonar
89% matchNo user reviews2026
Dev: lines in orbit studio
Windows · Linux
A tense twist on the classic Minesweeper game! Each missile has a Minesweeper grid, solve them to protect your boat and earn currency, use the currency to attack the enemy ship and repair you boat.
Why similar: RTS 24.8%, Moddable 23.8%, Minimalist 13.3%, Logic 12.2%, Strategy 10.6%
- #13 SimShock2025
87% match7 user reviews75% of 8 reviews2025
Dev: Pablo Kessler SaizPub: Pablo Kessler
Windows · Mac
SimShock2025 is a free, bilingual (EN/ES) hemodynamic shock simulator. Treat cardiogenic, hemorrhagic, and septic shock using real drugs and interventions. Written in PureBasic, available for Mac and Windows. Apple-signed and notarized.
Why similar: Medical Sim 50.3% ★, RTS 28.7%, Education 17.6%, Simulation 1.3%, Top-Down 1.2%
- #14 COVID: The Outbreak
86% matchMostly Positive70% of 97 reviews2020
Dev: Jujubee S.A.Pub: Salient Games
Windows
Median: 3.2 hrsMean: 55.1 hrs≥1hr: 91%
COVID: The Outbreak is a real-time strategy game in which you play the role of a global organization that has to deal with a global pandemic. Issue decrees, manage resources, develop projects, and construct buildings. A race for the vaccine begins!
Why similar: Outbreak Sim 47.1% ★, RTS 14%, Education 10.5%, Abstract 9.2%, Strategy 7.8%
- #15 The Crawling Dead
84% matchPositive86% of 14 reviews2025
Dev: Quinton Van Lom
Windows
Design, deploy, and manage the release of parasitic wasps to save a national park from invasive insect pests. Harness the power of nature’s most efficient killers to strike back at the invaders and turn them into The Crawling Dead!
Why similar: Outbreak Sim 50.8% ★, RTS 16.3%, Education 13.5%, Science 9.7%, Strategy 7.9%
- #16 Pandemic Crisis
85% match9 user reviews100% of 9 reviews2020
Dev: Thor Gaming
Windows
In the event of a global pandemic, would your first priority be preserving lives or saving the economy?
Why similar: Outbreak Sim 46.2% ★, Medical Sim 42.4% ★, Strategy 8.3%, Management 1.3%, Simulation 0.8%
- #17 英雄荣光医院
83% match4 user reviews100% of 4 reviews2026
Dev: Areas RPub: PeopleFirstAI
Windows
“Hero Hospital” is a classic hospital management game: send in undercover agents and fake patient brokers, unleash dogs to cause crashes and chaos, dump trash and throw bombs, and even head into outbreak zones to fight viruses. The gameplay can be expanded endlessly.
Why similar: Medical Sim 49.7% ★, Outbreak Sim 41.1% ★, Strategy 5.8%, Management 2.9%, Simulation 0.5%
- #18 Ministry of Pandemic
84% match5 user reviews60% of 5 reviews2022
Dev: Ceyhan KapusuzPub: Cookie Mechanics
Windows
Ministry of Pandemic is a strategy and simulation game that forces social and economic balance during the pandemic. Formulate your strategy for survival while keeping all aspects of society steady.
Why similar: Medical Sim 38.5% ★, Outbreak Sim 34.2% ★, Education 10.5%, Science 7.4%, Strategy 6.2%
- #19 Just A Flu
82% matchNo user reviews
Dev: TheSociopathSoftware
Windows
Just A Flu is a strategy simulation game about fighting the deadly fast spreading disease. Decide how to deal with infected people, when to close transport hubs, declare quarantine, or lockdown. Can you not only stop pandemic but avoid panic and not destroy the economy, causing more harm?
Why similar: Outbreak Sim 47.7% ★, Education 14.4%, Minimalist 12.5%, Strategy 9.7%, Logic 8.8%
- #20 Unknot!
81% matchPositive91% of 33 reviews2025
Dev: P.F.J.
Windows · Mac
Unknot! is a physics-simulation puzzle game where you unknot knots with simple controls, based on knot theory. Blending art, puzzles, and math, it delivers a unique experience—whether you’re a casual player or a hardcore puzzle enthusiast.
Why similar: Abstract 20.6%, Physics 20.5%, Minimalist 19.1%, Science 15.1%, Logic 14.4%
- #21 Traditional Chinese Medicine Simulator
81% matchVery Positive96% of 311 reviews2021
Dev: 曲波
Windows · Mac
《中医模拟器》是一款独特的个人制作游戏,风格和市面绝大多游戏不同,定位是帮助中医爱好者或学生更有兴趣和效率学习中医,并且帮助中医0基础玩家入门。 可以加群 494811550(学习群),697138589(已满),302219333(第2群已满),欢迎参加讨论。
Why similar: Medical Sim 55.1% ★, Minimalist 14.2%, Education 13.9%, Strategy 9.2%, Nonlinear 5.8%
- #22 Occupy
80% matchPositive83% of 23 reviews2025
Dev: BananaDogGames
Windows
Accumulate soldiers and capture cities. Choose the optimal attack routes and timing. Formulate strategies to adapt to the ever-changing battlefield and assemble your forces wisely. Defeat enemies, upgrade your troops, and take on even greater challenges.
Why similar: RTS 37.3%, Wargame 25.2%, Strategy 15.9%, Minimalist 13.6%, Tactical 7%
- #23 ICBM
79% matchVery Positive92% of 1,921 reviews2020
Dev: SoftWarWarePub: Slitherine Ltd.
Windows
Median: 3.6 hrsMean: 11.4 hrs≥1hr: 75%
ICBM is a real-time strategy game of nuclear destruction. Research new technologies, build up your nuclear stockpile and use a combination of ships, planes and missiles to strike at the heart of your opponents’ cities while keeping your population safe from harm.
Why similar: Outbreak Sim 30.1% ★, RTS 21.7%, Moddable 17%, Destruction 14.5%, Minimalist 5.8%
- #24 Dyin To Live
78% match1 user reviews100% of 1 reviews2023
Dev: Roguedolike
Windows
A contagious puzzle game where death is the only way to live! Use infectious abilities to expand your virus hive mind. But spread carefully, because each ability results in your host’s death! Master your deadly skills so you can live another day.
Why similar: Outbreak Sim 59.4% ★, Strategy 17%, Minimalist 13.6%, Logic 9%, 2D 0.8%
- #25 Ignis
78% match6 user reviews100% of 6 reviews2024
Dev: Hot Drink Studios
Windows
Ignis is a puzzle strategy game with the goal of burning down everything in your path. You control the spreading flames where strategic thinking is the difference between dying out or raging on.
Why similar: RTS 35.8%, Abstract 18.6%, Strategy 18%, Minimalist 14.5%, Nonlinear 11.7%
- #26 Orbital Trajectory
77% matchNo user reviews2026
Dev: ElastiCat
Windows
Plan, launch, and observe in a minimalist physics puzzle game about discovering trajectories through gravity fields and orbital currents.
Why similar: Physics 18.8%, Logic 18.2%, Abstract 18%, Strategy 17.9%, Minimalist 16%
- #27 Tower Doomer
76% match2 user reviews100% of 2 reviews2024
Dev: Beefton Ballon Games
Windows
satisfy your demolishing urges with Tower Doomer ! Complete levels in various environments or create your own demolishing derby in the sandbox mode. Tear down multiple structures by shooting at them or use gravity at your own advantage !
Why similar: Outbreak Sim 48.5% ★, Destruction 24%, Physics 16.3%, Strategy 6.5%, Logic 3.9%
- #28 Dodecadone
75% matchPositive89% of 46 reviews2024
Dev: coding398
Windows · Linux
A physics & logic puzzler about merging shapes and traits, similar to Suika games. A triangle might be bouncy, your septagon sick & coughing, or an ennenagon defying the laws of physics.
Why similar: Moddable 41.9%, Physics 21.8%, Strategy 17.3%, Minimalist 9.9%, Logic 6.8%
- #29 40 Days [四十天]
77% matchMixed50% of 12 reviews2017
Dev: Black Phoenix Studio
Windows · Mac
40 Days is a special strategy simulation game related to infectious diseases spread all over the city. You, as ahead of the quarantine department, have been given full authority and manpower to contain the city, deal with different parties, virus in the city and most importantly find out the cure.
Why similar: Outbreak Sim 86.7% ★, Strategy 10.2%, Management 2.1%, Simulation 1%
- #30 Angry Mother Earth
75% matchNo user reviews2026
Dev: Ice Quake GamesPub: Ice Quake Studios
Windows
Angry Mother Earth offers a one-of-a-kind strategy experience within an fully simulated world. Wield and merge a variety of abilities to release cataclysmic forces—ranging from hurricanes and earthquakes to blizzards—upon the world of humans. But be warned: humanity won't go down without a fight!
Why similar: Outbreak Sim 37.7% ★, RTS 24.5%, Destruction 16.8%, Strategy 10.4%, Tactical 7.5%
- #31 No.9
73% matchVery Positive89% of 106 reviews2024
Dev: Maciej Targoni
Windows · Mac · Linux
Synchronizing form and time.
Why similar: Moddable 34.5%, Abstract 28.2%, Minimalist 21.5%, Logic 14.1%, 2D 1.2%
- #32 疑義照会ウォーズ
74% matchMostly Negative30% of 20 reviews2021
Dev: 薬学ゲーム開発プロジェクト
Windows
This is a full-fledged adventure game (selectable type) based on the theme of the pharmacist's job, "checking prescription. Determine if the prescription is correct, and if it is, make a "Questionable Inquiry" to the doctor!
Why similar: Medical Sim 79.1% ★, Education 18.5%, Simulation 1.2%, 2D 0.8%, Singleplayer 0.4%
- #33 S4Game
73% matchNo user reviews
Dev: Viral Studios
Windows
S4Game aims to provide health professionals with an innovative approach to acquire soft skills to foster their professional development. Their main learning objective is the acquisition of soft skills required during work in an operating room, such as communication or teamwork.
Why similar: Medical Sim 76% ★, Education 17.9%, Strategy 5.1%, Singleplayer 0.6%, Simulation 0.5%
- #34 Trojan Inc.
74% matchMostly Negative36% of 33 reviews2017
Dev: WalkBoy Studio
Windows
Will you be able to infect all devices of the world? «Trojan Inc.» - simulator, which will involve you in a world of computer viruses and trojans.
Why similar: Outbreak Sim 86.7% ★, Strategy 12.1%, Simulation 1.1%
- #35 Graveyard Simulator
72% matchNo user reviews
Dev: Hollow CrowPub: Ultimate Publishing
Windows
Graveyard Simulator is a simulation game focused on strategy, design, and moral choices as you transform an abandoned cemetery into a prestigious memorial site. Take on daily graveyard tasks and delve deep into humanity’s relationship with death.
Why similar: Moddable 41.8%, Medical Sim 34.4% ★, Physics 22.9%, Simulation 0.9%
- #36 RoboDoc Jr
73% matchNo user reviews2025
Dev: Marion SurgicalPub: Marion Surgical Inc
Windows
A fun space adventure game where kids become alien medics! Use cool futuristic tools to help friendly aliens across 12 exciting missions. Solve puzzles, fix alien tech, and save the day with steady hands and smart thinking!
Why similar: Medical Sim 78.5% ★, Education 20.5%, Simulation 0.5%, Singleplayer 0.4%
- #37 CAR TUNE: Project
71% matchVery Positive84% of 609 reviews2020
Dev: Vertices Software
Windows
CAR TUNE: Project is a detailed car tuning simulator where every bolt, screw, and gear matters. Build your dream machine, fine-tune every parameter, and test it on the track.
Why similar: Moddable 30%, Nonlinear 13.6%, Minimalist 13.1%, Destruction 12%, Science 12%
- #38 Rescue Operations Simulator
71% matchNo user reviews
Dev: Monuments Games
Windows
Rescue Operations Simulator is a game where you play the role of USAR (Urban Search and Rescue) member and a team leader. You will arrange and execute rescue operations from real life catastrophic events that shocked and changed the whole world.
Why similar: Medical Sim 47.7% ★, Outbreak Sim 46.1% ★, Nonlinear 5.2%, Simulation 0.9%, Singleplayer 0.1%
- #39 Pandemic: The Virus Outbreak
72% matchMostly Negative33% of 12 reviews2020
Dev: John's Project
Windows · Linux
Are you good enough to make your country overcome the pandemic? Try it out! You're the president of a new country, In 1/1/2020 a pandemic started and you have to manage the country balancing 8 constantly chaging statistics using isolation measures or budget investments.
Why similar: Outbreak Sim 41.7% ★, RTS 22.2%, Abstract 11.8%, Minimalist 10.1%, Strategy 7.5%
- #40 Within the Range
71% matchMixed56% of 241 reviews2021
Dev: Aries
Windows
This game is no longer updated, do not buy!! RTS with physical details. Formulate strategies based on terrain and unit characteristics
Why similar: RTS 43.5%, Wargame 26.9%, Strategy 17.2%, Physics 12%, Singleplayer 0.4%
- #41 Supermarket Maker
70% matchNo user reviews
Dev: El NanPub: La Blen
Windows
Build and manage your very own Supermarket and make it success, with good offers and best selected products. Attract more customers with an aggressive strategy and grow to become the best Supermarket in town.
Why similar: Medical Sim 48.8% ★, Outbreak Sim 37.8% ★, Minimalist 9.3%, Management 2.5%, Simulation 1.4%
- #42 Medic Simulator
70% matchNo user reviews
Dev: Eathrabaria
Windows
Become a doctor and treat patients in every area of medicine. Become a cardiologist, psychiatrist, dentist, dermatologist, oncologist, surgeon, ophthalmologist, neurologist…!
Why similar: Medical Sim 65.7% ★, Nonlinear 16.7%, Science 15.5%, Simulation 1.7%, Singleplayer 0.4%
- #43 Quadphos
69% matchNo user reviews
Dev: arimx
Windows
Light up cells. Deduce rules. Solve puzzles.
Why similar: Abstract 29.1%, Nonlinear 25.4%, Minimalist 23.2%, Logic 20.7%, 2D 1%
- #44 Quarantine
70% matchMixed60% of 437 reviews2017
Dev: SproingPub: 505 Games
Windows
Median: 48 minMean: 3.2 hrs≥1hr: 40%
Quarantine is an intense turn-based strategy game about waging war on pandemic disease. Recruit a team of specialized operatives to deploy on worldwide missions. Research the contagion, upgrade your tech, and quarantine the outbreak before it kills us all.
Why similar: Outbreak Sim 78.5% ★, Strategy 13.7%, Tactical 6.9%, Simulation 0.9%
- #45 Plague Inc: Evolved
68% matchVery Positive94% of 64,060 reviews2016
Dev: Ndemic Creations
Windows · Mac · Linux
Median: 4.9 hrsMean: 16.4 hrs≥1hr: 88%
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
Why similar: Outbreak Sim 74.6% ★, Strategy 18.6%, Tactical 4.8%, Simulation 1.4%, Singleplayer 0.5%
- #46 Propple
68% match5 user reviews100% of 5 reviews2025
Dev: Chocolate Bar Games
Windows
A somewhat rage-inducing physics-based puzzle game about manipulating objects with your mouse cursor. Gently nudge, quickly knock, or try to carry any objects to bring them to their target.
Why similar: Physics 24.4%, Abstract 20.7%, Strategy 18.8%, Destruction 17.3%, Logic 17.3%
- #47 MegaRamp
69% matchPositive85% of 13 reviews2020
Dev: TooIzzi Games
Windows
In this game you have to position the game elements in a exact way to get the ball from the top of a ramp inside a basket on its botton. The game uses real world physics on the ball movement and all your sense of localization will be demanded to complete the challenges.
Why similar: Nonlinear 20.9%, Minimalist 20.9%, Physics 18.1%, Logic 17.7%, Strategy 12.5%
- #48 NEURAL NETWORK
67% matchNo user reviews2026
Dev: Troshkin AndreiPub: HERRTROST GAMES
Windows · Linux
NEURAL NETWORK is a unique blend of strategy and frighteningly realistic simulation. Your artificial intelligence has just been launched and connected to the global network - now you must manage and control it! Will your AI save the world or destroy humanity?
Why similar: Outbreak Sim 51.6% ★, RTS 18.2%, Wargame 17.2%, Strategy 8.3%, Management 3.9%
- #49 Fun Hospital
68% matchMixed64% of 600 reviews2018
Dev: OrangesGame Technology Limited
Windows · Mac
Median: 1.2 hrsMean: 32.8 hrs≥1hr: 52%
Build your own theme hospital! Here, you might meet patients with a lot of hair, or no hair; strange aliens, evil guy, super hero…
Why similar: Medical Sim 79.4% ★, Strategy 18.8%, Simulation 1.7%
- #50 Extremely Realistic Siege Warfare Simulator
67% matchMixed53% of 369 reviews2022
Dev: Screambox Studio
Windows
Median: 36 minMean: 5.8 hrs≥1hr: 40%
Extremely Realistic Siege Warfare Simulator is a physics-based tactical strategy game where you must lead a military force in a fantasy medieval world. Build an army. Construct siege equipment. Experience epic battles. Lead your people to victory!!
Why similar: RTS 28.7%, Moddable 25.7%, Wargame 16.2%, Physics 13.5%, Strategy 8.4%
- #51 Rochford Reanimated
66% matchNo user reviews
Dev: aweasd
Windows
Rochford Reanimated is a card-based survival strategy game set in a zombie apocalypse. Lead survivors on missions, manage resources, and make tough choices to rebuild your community or fall to the undead. Every decision could be your last.
Why similar: Outbreak Sim 43.6% ★, RTS 25.9%, Minimalist 11.7%, Strategy 8.3%, Tactical 7.9%
- #52 Empire Earth: Gold Edition
64% matchVery Positive87% of 132 reviews2026
Dev: Stainless Steel StudiosPub: Rebellion
Windows
With dozens of hours of gameplay set across a rich tapestry of time, Empire Earth: Gold Edition offers real-time strategy for the ages. Choose any point in time - from the discovery of fire to the laser battles of the future - and command your civilization with one goal: make Earth your Empire.
Why similar: RTS 48.2%, Strategy 25.1%, Wargame 23.9%, Top-Down 2.2%, Singleplayer 0.6%