60+ similar titles based on shared tags and player behavior. Themes include Simulation, Outbreak Sim, Medical Sim, Singleplayer.
Fight ever-mutating bacteria and viruses, collect gene modules from fallen pathogens, evolve and strengthen your immune system, unlock a variety of medical interventions, and create powerful synergistic builds to survive an ever-escalating infection.
Life on the Edge
Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!
Nano Fighter Anti Disease
Nano Fighter Anti Disease is a flight action game. Controlling a nanoscale fighter, flies over the acid sea of digestive system, passes through the scarred inflammatory lesions, launch a fierce attack towards various pathogens with medicine ammos and biological missiles.
Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!
Why similar: Medical Sim 28% ★, Outbreak Sim 25.2% ★, Tower Defense 17.9%, Science 15.4%, Strategy 5.1%
Nano Fighter Anti Disease is a flight action game. Controlling a nanoscale fighter, flies over the acid sea of digestive system, passes through the scarred inflammatory lesions, launch a fierce attack towards various pathogens with medicine ammos and biological missiles.
Why similar: Outbreak Sim 35.8% ★, Medical Sim 35.8% ★, Real Time Tactics 11.8%, Science 10.5%, RTS 3.2%
No Emergency: Pestilence plunges players into the epicenter of a mysterious epidemic, where every arriving patient could be carrying a mutating pathogen, and a single mistake in a prescription turns the cure into poison.
Why similar: Medical Sim 43.9% ★, Outbreak Sim 42.2% ★, Roguelike 8.1%, Simulation 5.2%, Indie 0.5%
In a city where death lingers in the air, you are the last one who can resist it. Put on the plague doctor’s mask and fight the plague before it reaches you.
Why similar: Medical Sim 45.7% ★, Outbreak Sim 44.3% ★, Simulation 5%, Survival 3.6%, Realistic 1%
《中国战疫》是一款科普防疫知识的模拟经营类游戏，玩家将临危受命地前往不同地区进行疫情控制，展示中国防疫的成功经验，最终达成疫情控制和经济稳定的双赢。
Why similar: Outbreak Sim 40.1% ★, Medical Sim 38% ★, Roguelite 7.6%, RTS 7.6%, Strategy 3.1%
Ministry of Pandemic is a strategy and simulation game that forces social and economic balance during the pandemic. Formulate your strategy for survival while keeping all aspects of society steady.
Why similar: Outbreak Sim 33.7% ★, Medical Sim 33.2% ★, Real Time Tactics 11.3%, Science 7.9%, Automation 6.8%
FinalFort is a survival game with defense as the core gameplay, and when the end comes, you use the last human shelter to constantly dig minerals, build walls and various turrets to defend against the endless zombie army.
Why similar: Outbreak Sim 38.1% ★, Tower Defense 16.6%, Real Time Tactics 15.3%, RTS 10.9%, Roguelike 7.5%
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
Why similar: Medical Sim 43.7% ★, Outbreak Sim 40.2% ★, RTS 6.8%, Strategy 4.3%, Simulation 2.7%
In this RTS game, control your virus to replicate and evolve against a powerful immune system. Equip gene segments to create unique viral armies. Use tactics to eliminate immune cells or achieve escape. Develop strategies for domination and enjoy endless strategic fun!
Why similar: Medical Sim 35.2% ★, Outbreak Sim 34.8% ★, RTS 10.1%, Physics 7.3%, Science 5.8%
In the event of a global pandemic, would your first priority be preserving lives or saving the economy?
Why similar: Outbreak Sim 47.8% ★, Medical Sim 38.4% ★, Strategy 5.5%, Simulation 3.6%, 2D 2.8%
When your airplane enters a massive storm, you aren’t a passenger anymore. You are a survivor. Trapped at 35,000 feet, you need to keep a cool head and act fast to live through the crisis. Can you make it to a happy landing?
Why similar: Outbreak Sim 44.8% ★, Medical Sim 41.2% ★, Simulation 5.9%, Physics 4.6%, Survival 3.4%
Design, deploy, and manage the release of parasitic wasps to save a national park from invasive insect pests. Harness the power of nature’s most efficient killers to strike back at the invaders and turn them into The Crawling Dead!
Why similar: Outbreak Sim 53.3% ★, Real Time Tactics 15.8%, Science 11%, RTS 6.8%, Strategy 5.3%
Team up with survivors, customize your character, and combine over 70 weapons and items to defend your central tower against endless waves of enemies. Choose your skills, craft insane synergies, and unleash chaos in intense bullet-hell combat.
Why similar: Outbreak Sim 50.1% ★, Tower Defense 16.9%, Survival 10.2%, Roguelike 6.9%, Top-Down 5.5%
A young Plague Doctor, only to learn that the Academy sent to a small village, which, like the whole country is gripped by plague
Why similar: Outbreak Sim 38.1% ★, Medical Sim 36.4% ★, Science 11.2%, Survival 8.3%, Horror 2.1%
Post-apocalyptic survival simulator set after an asteroid (or asteroids) impact.
Why similar: Outbreak Sim 33.2% ★, Medical Sim 31.5% ★, Tower Defense 12.6%, Science 10.1%, Survival 6.5%
Gelluloid Domination is a fast-paced, strategic and tactical game where you grow a network of cells. Expand by assimilating nearby cells, fight off pathogens and develop nanoboosts in the lab. Other cells want to propagate their DNA too, so this won't be easy. Can your cells achieve domination?
Why similar: Medical Sim 31.6% ★, Tower Defense 13.2%, Real Time Tactics 13.1%, Science 12.7%, RTS 8.3%
Will you be able to infect all devices of the world? «Trojan Inc.» - simulator, which will involve you in a world of computer viruses and trojans.
Why similar: Outbreak Sim 85.9% ★, Strategy 7.7%, Simulation 4.8%, Indie 1.6%
False Death has come to Grizmar. The plague steals souls and turns bodies into soulless puppets, doomed to repeat the final hours of their lives forever. Can you survive as the city turns into a puppet theater?
Why similar: Outbreak Sim 52.9% ★, Medical Sim 43.4% ★, Simulation 3%, Adventure 0.5%, Singleplayer 0.2%
40 Days is a special strategy simulation game related to infectious diseases spread all over the city. You, as ahead of the quarantine department, have been given full authority and manpower to contain the city, deal with different parties, virus in the city and most importantly find out the cure.
Why similar: Outbreak Sim 87.7% ★, Strategy 6.6%, Simulation 4.2%, Indie 1.4%
Dead Night Highway is a compact colony simulator where a group of survivors on their journey west sets up camps to replenish resources, but zombie horde only grows larger...
Why similar: Outbreak Sim 46.9% ★, Real Time Tactics 15.1%, Tower Defense 13.9%, RTS 8.1%, Survival 6.9%
During the pandemic, would you be curious about how our bodies react to the virus? Are you wondering: "What' is autoimmunity?" "All definitions and thesis of the immunology are too hard to understand!" Don't be afraid! After beating the game, you get all the necessary information and fun!
Why similar: Outbreak Sim 46% ★, Science 17.2%, RTS 11.4%, Roguelite 10.5%, Top-Down 5.4%
“Hero Hospital” is a classic hospital management game: send in undercover agents and fake patient brokers, unleash dogs to cause crashes and chaos, dump trash and throw bombs, and even head into outbreak zones to fight viruses. The gameplay can be expanded endlessly.
Why similar: Medical Sim 48.2% ★, Outbreak Sim 45.5% ★, Strategy 4.1%, Simulation 2.2%
The city is drowning in Plague. Panic, hunger, and fear are tearing it apart. You are the last one who can change its fate: heal it, hold it back from collapse… or drive it to ruin with your own hands!
Why similar: Medical Sim 47.4% ★, Outbreak Sim 47% ★, 2D 2.5%, Simulation 2.2%, Adventure 0.8%
Quarantine is an intense turn-based strategy game about waging war on pandemic disease. Recruit a team of specialized operatives to deploy on worldwide missions. Research the contagion, upgrade your tech, and quarantine the outbreak before it kills us all.
Why similar: Outbreak Sim 77.2% ★, Survival 9.5%, Strategy 8.6%, Simulation 3.9%, Indie 0.7%
Play as the zombies! Infect and Destroy is an indie game in which you play as an infectious disease with the sole purpose of eliminating everyone on Earth. Play as an ultra-intelligent self-aware virus capable of reanimating the dead and turning them into your minions.
Why similar: Outbreak Sim 83.2% ★, Strategy 6.6%, Survival 4.6%, Simulation 4.1%, Indie 1.4%
Strategically position units on a chess-based battlefield, defending territories while earning roguelike upgrade-items for leveling up. Discover over 30 unique equipment pieces that modify units, allowing for exciting customization and ensuring endless excitement and replayability.
Why similar: Tower Defense 21.7%, Real Time Tactics 20%, Roguelite 15.7%, Survival 14%, RTS 9.4%
A top-down plague simulation RPG set in a living medieval tapestry. Play the last apothecary in a dying town treating the sick, containing the outbreak, and navigating the politics of factions who'd sooner see you burn.
Why similar: Medical Sim 56.4% ★, Outbreak Sim 38.1% ★, Simulation 3%, Adventure 2.1%, Singleplayer 0.3%
Evil Labs is a game about building and managing your own Evil Laboratory. Research and develop diseases, infect people, sell the cure and get rich!
Why similar: Outbreak Sim 85.2% ★, Strategy 7.6%, Simulation 5.3%, Indie 1.7%, Singleplayer 0.3%
Layered Loop is a minimalist tower defense game built on stacking & evolution. Towers auto-level to boost damage/production, evolve via devouring key structures for new abilities or stat boosts. Stack towers with full effects retained, unlock global buffs at 5 layers.
Why similar: Real Time Tactics 24.3%, Tower Defense 23.6%, Roguelite 18.3%, RTS 14.5%, Roguelike 10%
这是一款休闲益智类游戏。根据经典的PVZ类游戏的核心玩法的基础上，创新题材，创新无尽模式。
Why similar: Outbreak Sim 45.6% ★, Tower Defense 18.9%, Real Time Tactics 17.5%, Strategy 6.5%, Survival 4.8%
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
Why similar: Outbreak Sim 76.3% ★, Strategy 12.1%, Simulation 6.1%, Survival 2.2%, Indie 1.3%
Create strategies, evolve and defende the castle!
Why similar: Tower Defense 27%, Real Time Tactics 23%, Roguelite 17.2%, Strategy 13.3%, Survival 8.1%
Patient Zero: Plague Idle is an idle / incremental outbreak builder where you create the perfect pathogen through mutation trees, global infection, long-term upgrades, and new pathogen unlocks. Turn the world into your lab.
Why similar: Outbreak Sim 47.6% ★, Medical Sim 25.2% ★, Automation 13.2%, Strategy 5.5%, Simulation 3.4%
Examine and test patients for common and novel infections using sophisticated medical instrumentation and disinfection procedures. All infected patients must be sent to the isolation ward for further evaluation or treatment. Rumors of mysterious diseases and human experimentation are unconfirmed.
Why similar: Outbreak Sim 61% ★, Medical Sim 30.8% ★, Simulation 5.5%, 2D 2.1%, Singleplayer 0.7%
BALL MACHINE is real-time strategy driven by pinball. Launch creature marbles, gather red, green, and blue paint energy, and buy units, cartridges, upgrades, structures, and tactical tools. Command the battlefield against the standard AI or asynchronous builds formed from your own past decisions.
Why similar: Tower Defense 22.3%, Real Time Tactics 17.5%, RTS 15.4%, Roguelite 11.5%, Strategy 11%
Build barricades and face spectacular natural disasters in a relaxing physics-based game where every structure can save lives.
Why similar: Outbreak Sim 66.9% ★, Tower Defense 20.6%, Physics 8%, 2D 3%, Indie 1.1%
Geometry Defense is a fast-paced geometric shooter where every level brings a new choice. Choose from random upgrade gates, combine powerful abilities, and evolve your strategy as enemies grow stronger. Experience simple controls, endless combinations, and satisfying progression.
Why similar: Tower Defense 26.1%, Real Time Tactics 22.9%, Roguelite 15%, RTS 13.2%, Strategy 8.8%
It’s time for the zombies to take revenge. Humanity has been happy for far too long, use your arsenal of unholy powers, mutated zombies, and destructive totems to put humanity back in its place in this strategy roguelike game.
Why similar: Outbreak Sim 59.5% ★, Roguelite 13.6%, Roguelike 7.5%, Top-Down 6.9%, Strategy 6.3%
Rescue Operations Simulator is a game where you play the role of USAR (Urban Search and Rescue) member and a team leader. You will arrange and execute rescue operations from real life catastrophic events that shocked and changed the whole world.
Why similar: Outbreak Sim 49.1% ★, Medical Sim 44.5% ★, Simulation 4.3%, Realistic 1.9%, Indie 0.2%
Defend attacks from enemies from all directions within a limited time. Only by making full use of the differences in each tower and choosing appropriate random rewards can you survive.
Why similar: Tower Defense 21.2%, Real Time Tactics 19.8%, RTS 13.9%, Roguelite 12.9%, Roguelike 9.6%
You are an apprentice of a traditional Chinese medicine herbalist in South Village. Your task is deceptively simple: Examine the pulse, ask about the symptoms and verify the identity of villagers and outsiders to expose the hidden "false people" from the diagnostic details.
Why similar: Outbreak Sim 50.2% ★, Medical Sim 45.6% ★, 2D 2.5%, Simulation 1.3%, Adventure 0.2%
Become the plague in an asymmetrical player verses simulation battle for immortality. Infect populations, collapse economies, and harvest the dead to fuel your path to lichhood; only if you can conquer an adaptive world fighting to survive.
Why similar: Outbreak Sim 62.7% ★, Real Time Tactics 20.1%, RTS 5.9%, Strategy 5.7%, Simulation 4.3%
This is a innovative roguelike TD game made with the 『CliCli』. No need for path planning or tower combos—just one tower! With almost 100 weapons, you’ll be mowing down foes and dominating the battlefield. Enjoy the rush and let off some steam!
Why similar: Tower Defense 22.9%, Real Time Tactics 15.7%, Survival 14%, Roguelite 12.8%, RTS 10.9%
Strategically position units on a chess-based battlefield, defending territories while earning roguelike upgrade-items for leveling up. Discover over 30 unique equipment pieces that modify units, allowing for exciting customization and ensuring endless excitement and replayability.
Why similar: Tower Defense 21.4%, Real Time Tactics 20%, RTS 14.6%, Roguelite 13%, Roguelike 10.9%
DeadOS is an early access zombie outbreak simulator by Benn Powell that focuses on city-wide scenarios where you have access to fully customize your apocalypse experience from beginning to end. Simulation. Sandbox. Survival!
Why similar: Outbreak Sim 90.4% ★, Survival 4.5%, Simulation 3.6%, Indie 1.3%, Singleplayer 0.2%
Save Us, Doctor Faust! is an immersive medieval doctor simulator where you diagnose diseases, study medicine, and craft remedies from raw ingredients. Examine your patients, grind and distill ingredients, experiment with recipes — and remember: one mistake could cost a life.
Why similar: Medical Sim 52.6% ★, Outbreak Sim 41.9% ★, Simulation 4.2%, Adventure 1%, Singleplayer 0.3%
Plague Architect is a strategic outbreak simulator set in a mall. Evolve symptoms and abilities to spread infection. Watch chaos unfold.
Why similar: Outbreak Sim 64.9% ★, Survival 10.1%, Top-Down 8.3%, Strategy 7.5%, Simulation 5%
"Pathogen" is a STG game base on real human body with little Rogue-Like element. You can propagate evolve infect and hide as different kinds of pathogens in human body.
Why similar: Outbreak Sim 79.4% ★, Roguelite 10.2%, Simulation 6.8%, Indie 2.3%, Adventure 1.2%
前世死于兽潮，今生逆转乾坤！《末世重生：兽皇计划》是一款高自由度的轻塔防+肉鸽策略游戏，你将扮演一名重生的基因科学家，培育出传说中的山海经异兽，突破基因限制，为异兽注入超凡力量，对抗即将席卷世界的狂暴兽潮！
Why similar: Tower Defense 27.7%, Real Time Tactics 18.9%, RTS 14.4%, Strategy 10.7%, Roguelite 10.2%
Collect a 3D puzzle, transferring things to the right places to create a beautiful house.
Why similar: Outbreak Sim 45% ★, Medical Sim 44.7% ★, Roguelite 10.3%
"Galactic Defense: Automation" is a Placement, Automated Battle, Real-Time Strategy game. Players can place construction plans, observe automated construction, automated battles, and unlock new technologies. Players pass the level after collecting tech points through activities.
Why similar: Tower Defense 22.4%, Real Time Tactics 20.9%, RTS 14.8%, Automation 14.4%, Roguelite 13.8%
An exciting survival game with roguelike elements in which you have to play as a police officer in a city engulfed by a pandemic, look for infected people and isolate them, manage the budget and hire police officers, set up vaccination centers and propaganda stands.
Why similar: Outbreak Sim 67.4% ★, Roguelite 10.4%, Survival 7%, Simulation 5.9%, Top-Down 5.9%
A free, first-person, short medical horror experience that is an early rendition of the prequel we envisioned for Negative Atmosphere.
Why similar: Medical Sim 43% ★, Outbreak Sim 42.7% ★, Automation 9.3%, Simulation 1.9%, Horror 1.5%
Rochford Reanimated is a card-based survival strategy game set in a zombie apocalypse. Lead survivors on missions, manage resources, and make tough choices to rebuild your community or fall to the undead. Every decision could be your last.
Why similar: Outbreak Sim 47.4% ★, Real Time Tactics 15.9%, RTS 11.2%, Survival 7.9%, Top-Down 5.9%
Virus Petya - a simulator of the system administrator. In this game you need to run from one computer to another, to remove from the computer a terrible virus "PETYA". But it's not easy, because with each attempt of the virus to infect the computer, the virus gets closer to the end of his successful work
Why similar: Outbreak Sim 86.3% ★, Simulation 5.8%, Adventure 3.2%, 2D 2.3%, Indie 2%
Once a thriving alien world, now a vast desert—devoured by the relentless Swarm. These towering insect invaders have left only scattered oases and buried ruins. Grow food, craft powerful resources, and uncover lost secrets to push back against the tide and restore balance to a dying world.
Why similar: Outbreak Sim 71.6% ★, Survival 12.5%, Strategy 7.8%, Top-Down 5.9%, Simulation 2%
Escape from the Zombie Island Use cards scattered around the map to collect items Craft items Attempt to escape before the map is overrun by zombies
Why similar: Outbreak Sim 60.4% ★, Real Time Tactics 19.5%, Strategy 13.5%, 2D 2.7%, Simulation 2.6%
